Clinical trials: Ketosis, Metabolic
Obesity, Fatty Liver
Evaluation of Liver and Cardiometabolic Health Benefits on Low Carbohydrate Ketogenic Diet
To evaluate the impact of a Low Carbohydrate Ketogenic Diet (LCKD) weight loss program and compare to the standard of care program established for patients with Non-Alcoholic Fatty Liver Disease (NAFLD) on: (1) Liver fat and…
- Conditions
- Obesity, Fatty Liver, Ketogenic Dieting
- Trial name
- NCT03141008
- Testing
- Fibroscan changes with different diets
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Diabetic Ketoacidosis
Children with Diabetic Ketoacidosis
In the present work we aim to 1. Response to therapy, During the management of DKA, acid base status, glycemia, and serum electrolytes are measured frequently to monitor the efficacy of treatment, detect complications of DKA and…
- Trial name
- NCT06599203
- Volunteers
- 130 people
- Sponsor
- Assiut University
Type 1 Diabetes, Diabetes Mellitus
Therapeutic Education in Very Young Children With Diabetes Mellitus
DIAB-EDUC tests in a group of young diabetic patients (less than 6 years old) a specific educational tool in order to assess its impact on glycemic control, quality of life, knowledge about the disease and its daily management…
- Trial name
- DIAB-EDUC (NCT01354288)
- Testing
- Educational tool
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes, Ketone Body Metabolism
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplement (made with standard food ingredients that do not contain ketone…
- Conditions
- Type 2 Diabetes, Ketone Body Metabolism, Ketones, Metabolism
- Trial name
- NCT06078683
- Testing
- Ketone Ester Acute
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Ketonemia
Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants
Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.
- Trial name
- Opti-MCT (NCT03830268)
- Testing
- No MCT intake with breakfast, no lunch, No MCT intake with lunch, no breakfast, 10g of Betaquik
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetic Ketoacidosis, Type 1 Diabetes
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management
- Conditions
- Diabetic Ketoacidosis, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- NCT04567225
- Testing
- Early Glargine, Late Glargine, IV insulin infusion
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The Cleveland Clinic
Diabetic Ketoacidosis, Diabetes Mellitus
Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis
This prospective cohort study aims to evaluate the relationship between admission Leukocyte Glucose Index (LGI) and the severity of diabetic ketoacidosis, as well as the presence of diabetic microvascular complications, among…
- Trial name
- NCT07821814
- Volunteers
- 120 people
- Sponsor
- Assiut University
Type1diabetes
Effects of Ketosis on Brain Function in Patients With T1DM
The scientific goal of this study is to examine the effects of a ketogenic diet on hypoglycemia tolerance and brain function in people with type 1 diabetes mellitus (T1D) and to clarify the mechanistic role of ketones in this…
- Trial name
- NCT04219709
- Testing
- Very low carbohydrate diet, Standard carbohydrate diet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Boston Children's Hospital
Healthy Aging
Effect of a Two-month Carbohydrate-restricted Diet on Energy Metabolism in a Seniors' Residence
The present study will assess the effects on glucose, ketones and other blood biomarkers fuels, cognition, quality of life, physical activity and well-being of a reduced carbohydrate menu (R-CHO) for 2 months in a population…
- Trial name
- SAGE (NCT06022094)
- Testing
- 2 months of reduced carb menus
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Heart Failure, Systolic, Ketonemia
Effects of Ketones and Niacin in Heart Failure Patients
Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction.
- Trial name
- KETO-COX (NCT04703361)
- Testing
- Niacin, Na-3-OHB
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Alcohol Use Disorder, Ketosis
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use…
- Trial name
- KABA (NCT06807918)
- Testing
- Kenetik, magnetic resonance imaging scan, Alcohol bar lab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Intermittent Fasting, Healthy
Monitoring Intermittent Fasting for Human Optimization Using Wearable Technology: An N-of-1 Study
There is a growing interest in personalized health strategies, including diet, exercise, and fasting regimens, to enhance metabolic fitness.
- Conditions
- Intermittent Fasting, Healthy, Digital Health
- Trial name
- NCT06630637
- Testing
- Glucose-Ketone Index (GKI) monitoring, Continuous Glucose Monitoring (CGM), Digital dynamometer
- Where
- Singapore
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Institute for Digital Medicine (WisDM)
Ketones, Metabolism
Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers
The purpose of this study is to help us better understand how plasma ketones respond to a low-carb diet when combined with an SGLT2 inhibitor.
- Trial name
- CASINO (NCT05662865)
- Testing
- SGLT2 inhibitor, Controlled, Adaptive Study Diet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Healthy
Effect of an Alpha-linolenic Acid-rich Supplement on Ketogenesis and Plasma Fatty Acids
Background: As the main alternative fuel to glucose for the brain, increased plasma ketones could potentially help compensate for brain glucose hypometabolism occurring during aging.
- Trial name
- NCT02410161
- Testing
- alpha-linolenic acid-rich supplement
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Type 2 Diabetes
SGLTi, Hepatic Glucose Production and Ketogenesis
In this study, we will test the hypothesis that distinct mechanisms account for the SGLT2i-induced stimulation of ketogenesis and lipolysis versus endogenous (hepatic) glucose production in patients with type 2 diabetes (T2D) and…
- Trial name
- NCT05960656
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cerebral Edema, Diabetic Ketoacidosis
Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis
The investigators will conduct a randomized controlled trial comparing four different intravenous (IV) fluid treatment protocols for pediatric diabetic ketoacidosis (DKA).
- Trial name
- NCT01365793
- Testing
- 0.45% saline replacement fluid, 0.9% saline replacement fluid, 0.45% saline intravenous fluid
- Where
- 13 sites in United States
- Volunteers
- 1,389 people
- Sponsor
- University of California, Davis
Appetite, Obesity
Exogenous Ketones and Appetite
People with obesity have different appetitive responses to stimuli compared to people without obesity. For example, people with obesity have a blunted postprandial ghrelin ('hunger' hormone) response, lower glucagon-like peptide…
- Conditions
- Appetite, Obesity, Ketones, Appetitive Behavior
- Trial name
- NCT06327464
- Testing
- Exogenous ketones
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Healthy Adults
Evaluation of the Ketogenic Potential of Different Diet Supplements
Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.
- Trial name
- NCT02693106
- Testing
- Control, Leucine, Butyrate -
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke