Clinical trials: Ketosis, Metabolic
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
DKA
Early Administration of Insulin Glargine in Patients With Diabetic Ketoacidosis
Diabetic ketoacidosis (DKA) is a medical emergency that is associated with significant morbidity and mortality for both patients with type I and type II diabetes.
- Trial name
- NCT06007508
- Testing
- Insulin Glargine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- HealthPartners Institute
Obesity, Appetite
Study of the Effect of a Very-Low-Carbohydrate Diet on Energy Expenditure
Background: Popular weight loss plans often restrict carbohydrates or fat. Research shows that very-low-carbohydrate (ketogenic) diets lead to greater weight loss than low-fat diets.
- Conditions
- Obesity, Appetite, Healthy Volunteers
- Trial name
- NCT01967563
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Exercise, Healthy Male/Female Subjects
Ketone Administration During Inactivity and Retraining
The aim of this study is to investigate the effect of oral ketone administration during inactivity-induced muscle atrophy and retraining-induced regeneration.
- Trial name
- NCT05398042
- Testing
- Ketone ester, Medium Chain Triglyceride (MCT) oil
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Type 1 Diabetes Mellitus
Dapagliflozin Plus Pioglitazone in T1DM
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120…
- Trial name
- NCT03878459
- Testing
- Pioglitazone 45 mg
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 1 Diabetes
Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration?
Previous data from our clinical trial has demonstrated that the combination of dapagliflozin plus pioglitazone cause robust decrease in the plasma glucose concentration without significant increase in plasma ketone concentration…
- Trial name
- NCT06922656
- Testing
- Dapagliflozin (DAPA), Pioglitazone 45 mg
- Where
- 3 sites in Kuwait, Qatar and 1 more
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Renal Insufficiency, Chronic, Polycystic Kidney Diseases
Effects of Exogenous Ketosis on Proteinuria and Renal Function
A randomized, placebo-controlled, double-blinded crossover study will be conducted. Fourteen patients with polycystic kidney disease (PKD) and 29 patients with proteinuric kidney disease will receive ketone bodies (Ketone-IQ) and…
- Conditions
- Renal Insufficiency, Chronic, Polycystic Kidney Diseases, Proteinuria, Ketosis
- Trial name
- KETO-CKD (NCT06867471)
- Testing
- Ketone Diol, R-1,3-butanediol (Ketone-IQ)
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Gødstrup Hospital
Fasting, Autophagy
Time Course for Fasting-induced Autophagy in Humans
Autophagy, which involves the degradation of aged or damaged cellular components, has been shown to extend healthspan and lifespan in multiple organisms, including flies, worms, and mice.
- Conditions
- Fasting, Autophagy, Aging Well, Ketosis, Metabolic
- Trial name
- NCT04842864
- Testing
- Fasting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Type1diabetes
Type 1 Diabetes Management Using a Very Low Carbohydrate Versus Standard Diet
Despite major technological advances, management of type one diabetes mellitus (T1D) remains suboptimal, putting millions of people at risk for immediate and long-term complications.
- Trial name
- NCT03710928
- Testing
- very low carbohydrate diet, standard carbohydrate diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Boston Children's Hospital
Ketosis, Hypoxia
The Effect of Butanediol Ingestion on Skeletal Muscle Angiogenesis in Hypoxia
This study specifically aims to elucidate the effects of intermittent exogenous ketosis (IEK) as well as hypoxia on muscular pro-angiogenic factors- after a 60-min HIIT bout in normoxia.
- Conditions
- Ketosis, Hypoxia, Angiogenesis
- Trial name
- NCT06472427
- Testing
- Normoxic recovery and ketones (NKE), Hypoxic recovery and ketones (HKE)
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Ketoses, Metabolic
Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake
The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism
- Trial name
- NCT05238805
- Testing
- Observational heart and kidney on siemens TEP scan
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Ketosis Prone Diabetes, Diabetes Ketoacidosis
Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment
The study intends on enrolling 48 subjects with diabetes. Diabetic subjects that no longer need insulin will be randomly placed (like the flip of a coin) on a diabetes pill called metformin, a diabetes pill called sitagliptin or…
- Conditions
- Ketosis Prone Diabetes, Diabetes Ketoacidosis, Hyperglycemia
- Trial name
- NCT01099618
- Testing
- metformin, Sitagliptin
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dawn Smiley MD
Menopause
Health, Imaging, and Cognition Across the Menopausal Transition
This observational cross-sectional study aims to better understand how the menopausal transition affects brain energy metabolism and cognition.
- Trial name
- MOSAIC (NCT07021664)
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- Université de Sherbrooke
Ketosis, Acute-Phase Response
Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers
This study aims to investigate the early metabolic effects and acute phase response of an oral clear supplement containing whey protein plus carbohydrates in young healthy volunteers during fasting-induced organic response
- Conditions
- Ketosis, Acute-Phase Response, Insulin Resistance
- Trial name
- NCT05656339
- Testing
- CHO+WP, CHO, Fast
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Ketosis Prone Diabetes, Diabetic Ketoacidosis
Ketosis Prone Diabetes in African-Americans
Over 50% of obese African-Americans (AA) presenting with newly diagnosed, severe hyperglycemia and/or unprovoked diabetic ketoacidosis (DKA) display clinical, metabolic, and immunogenetic features of type 2 diabetes.
- Conditions
- Ketosis Prone Diabetes, Diabetic Ketoacidosis, Severe Hyperglycemia
- Trial name
- NCT00426413
- Testing
- pioglitazone
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Failure
Metabolic Effects of Chronic Ketosis (KETO-CHF Metabolic)
Heart Failure (HF) is a major public health issue because the disease affects 1-2% of the Western population and the lifetime risk of HF is 20%.
- Trial name
- NCT05161676
- Testing
- Ketone monoester
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
Type 1 Diabetes
Effects of Single Doses of Liraglutide and Dapagliflozin on Ketogenesis in Type 1 Diabetes
1. To compare levels of ketone bodies (beta-hydroxybutyrate and acetoacetate) in plasma and urine following a single dose treatment of either liraglutide 1.8mg, dapagliflozin 10mg or placebo in insulinopenic state. 2.
- Trial name
- 1974 (NCT02777073)
- Testing
- Victoza, Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University at Buffalo
Ketosis, Glucose Metabolism
Ketone Supplements and Substrate Oxidation and Physical Performance
The objective of this randomized crossover study is to examine the influence of consuming a ketone ester plus carbohydrate (KE+CHO) supplement on substrate oxidation and physical performance in 15 healthy adults.
- Trial name
- NCT04737694
- Testing
- Ketone ester, Glucose
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Heart Failure With Reduced Ejection Fraction
Ketones in Heart Failure With Reduced Ejection Fraction
The purpose of this study is to understand the effects of a ketone drink on exercise capacity and other cardiovascular parameters in patients with heart failure.
- Trial name
- HFrEF (NCT06195982)
- Testing
- ketone ester
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Alzheimer's Disease
AC-1204 Long-term Efficacy Response Trial (ALERT Protocol)
The study will evaluate the safety \& efficacy of AC-1204, a ketogenic compound, administered orally on a daily basis for 6 months.
- Trial name
- ALERT (NCT01211782)
- Testing
- caprylic triglyceride, long-chain triglyceride
- Where
- United States
- Sponsor
- Cerecin