Clinical trials: Kidney; Disease, Acute
Transplant;Failure,Kidney, Transplant; Failure, Pancreas
Eliminating the Need for Pancreas Biopsy Using Peripheral Blood Cell-free DNA
Donor-derived cell-free DNA (dd-cfDNA) has shown promise as an early marker for cellular injury caused by rejection. dd-cfDNA changes may also indicate other injuries that lead to progressive decline in transplant organ function…
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Pancreas, Rejection Acute Renal, Rejection Acute Pancreas
- Trial name
- PancDX (NCT04166149)
- Testing
- dd-cfDNA Blood Test
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Maryland, Baltimore
Renal Insufficiency, Chronic, Renal Dialysis
Acute Effect of Photobiomodulation on Quadriceps Muscle Strength in Patients With Chronic Kidney Failure on Hemodialysis
Chronic kidney disease (CKD) consists of kidney damage and progressive and irreversible loss of kidney function. The aim of this study is to evaluate the acute effect of different doses of photobiomodulation therapy on quadriceps…
- Trial name
- NCT05881772
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Cardiorenal Syndrome
Accuracy of Urinary NGAL in Predicting CardioRenal Syndrome in Acute Heart Failure at Emergency - CYNDERELA-HF Study
Rationale: Heart Failure (HF) elevated prevalence in Brasil and the world; 20-30% AHF patients develop CardioRenal Syndrome (CRS) type 1; Worsening Renal Failure (WRF) is a prognostic marker of mortality in Acute HF;NGAL is a…
- Trial name
- CYNDERELA-HF (NCT01364636)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Pro-Cardiaco Hospital
Acute Infection, Kidney Failure
Development of Antibodies Against Transplant Kidney After Infection
Kidney transplantation is the best method of renal replacement in patients with irreversible renal failure. One of the biggest problems today is premature loss of function of the transplanted kidney.
- Trial name
- NCT06040684
- Testing
- Level of antibodies
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Kidney Transplantation
A Study Looking at Kidney Function in Kidney Transplant Recipients Who Are Taking Anti-rejection Medication Including Tacrolimus and With or Without Sirolimus.
The purpose of this study is to compare the effect of two anti-rejection therapy regimens on kidney function in kidney transplant recipients.
- Trial name
- ADHERE (NCT01363752)
- Testing
- Advagraf, Mycophenolate Mofetil, Sirolimus
- Where
- 58 sites in Australia, Austria and 15 more
- Volunteers
- 853 people
- Sponsor
- Astellas Pharma Inc
Acute Kidney Injury
Establishment of ProNephro AKI (NGAL) Cut Off Value for Risk Assessment of Moderate to Severe Acute Kidney Injury in Adults
The purpose of this research is to collect blood and urine from adult patients admitted to an intensive care unit. This is to assess the performance of the ProNephro AKI (NGAL) assay (lab test) as an aid to identify patients at…
- Trial name
- EPACRA-AKI (NCT06652100)
- Testing
- ProNephro AKI (NGAL)
- Where
- 12 sites in United States
- Volunteers
- 800 people
- Sponsor
- BioPorto Diagnostics
Acute Kidney Injury, Cirrhosis
Droxidopa to Increase Mean Arterial Pressure in Decompensated Cirrhosis Patients With Acute Kidney Injury
This study tests whether a medication called droxidopa can help improve blood flow to the kidneys in people with liver cirrhosis who develop kidney problems while in the hospital.
- Conditions
- Acute Kidney Injury, Cirrhosis, Decompensated Cirrhosis of Liver
- Trial name
- DROP-AKI (NCT06937307)
- Testing
- Droxidopa capsules
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Giuseppe Cullaro, MD
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Kidney Injury, Outcome, Fatal
Effect of Weekend Admission on Mortality Associated With Severe Acute Kidney Injury in England: a Propensity Score Matched, Population-based Study
Increased in-hospital mortality associated with weekend admission has been reported for many acute conditions, but no study has investigated "weekend effect" for acute kidney injury requiring dialysis (AKI-D).
- Trial name
- NCT02947698
- Volunteers
- 53,878 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Acute Myocardial Infarction, Diabetes Mellitus
Association of Long-term Conditions With Survival Following Heart Attack in England and Wales
This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack…
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Peripheral Vascular Disease, Chronic Heart Failure
- Trial name
- NCT03037255
- Testing
- long term conditions
- Volunteers
- 693,633 people
- Sponsor
- Marlous Hall
Acute Kidney Injury Due to Circulatory Failure (Disorder)
The Effects of Oxiris on Systemic Inflammation and Endothelial dysFunction
CS-AKI occurring in 20% to 70% of cases depending of the type of cardiac surgery. The systemic inflammatory response is often observed and associated with increased risk of AKI.
- Trial name
- EOSIEF (NCT04257006)
- Testing
- oXiris membrane
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Acute Kidney Injury
Acute Kidney Attack in Severe Traumatized Patients
Acute Kidney Injury (AKI) is a common complication of severe traumatized patients. The diagnosis is often delayed. The Nephrocheck® test allows an earlier assessment of renal stress.
- Trial name
- NEPHROTRAUMA (NCT03877978)
- Testing
- Nephrocheck test
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury
Long-term Survival and Renal Outcomes in Critically Ill Patients After Acute Kidney Injury: Swedish Multi-centre Cohort Study
The study evaluates how outcome varies among critically ill patients with and without acute kidney injury. Data from the Swedish Intensive care register and other Swedish national registers is used to compare how survival and…
- Trial name
- NCT02424747
- Testing
- Acute Kidney Injury
- Volunteers
- 103,000 people
- Sponsor
- Karolinska Institutet
AKI - Acute Kidney Injury
Allopurinol and Trimetazidine as a Preventive of Acute Kidney Injury in PCI Patients
Contrast-associated acute kidney injury (CA-AKI) is a common complication of procedures with intravascular contrast. Generally, CA-AKI is defined as serum creatinine (Scr) ≥ 25 to 50% or Scr rise around 0.3 to 0.5 mg/dl.
- Trial name
- NCT05540184
- Testing
- Trimetazidine 35 mg, Allopurinol 300 MG, Normal saline
- Where
- Egypt
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Acute Kidney Injury
Dcr3 Levels in Blood and Urine on Renal and Patient Prognosis in Patients With Acute Kidney Injury
Kidney diseases represent a global public health problem due to the aging of the population, the increasing prevalence of diabetes, hypertension, obesity and immune disorders.
- Trial name
- NCT05735093
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kırıkkale University
Renal Failure
Safety and Efficacy of LCP-Tacro™ Once Daily in Stable Renal Transplant Patients Converted From Prograf® Twice Daily
This is 2-armed parallel group, prospective, randomized, open-label, multicenter Phase 3 controlled trial to establish the efficacy and safety of conversion from maintenance immunosuppressive therapy with Prograf® capsules…
- Trial name
- NCT00817206
- Testing
- LCP-Tacro, Prograf
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- Veloxis Pharmaceuticals
Heart Failure
Loop Diuretic Dosage in Patients With Acute Heart Failure and Renal Failure: Conventional Versus Carbohydrate Antigen 125-guided Therapy (IMPROVE-HF)
Worsening renal function (WRF) is a frequent finding in patients with decompensated acute heart failure (AHF) and it is associated to increased length of hospitalization and higher morbidity and mortality.
- Trial name
- IMPROVE-HF (NCT02643147)
- Testing
- CA125 guided strategy, Conventional Strategy
- Where
- Spain
- Volunteers
- 170 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Acute Kidney Injury
Acute Kidney Injury in Neonatal ICU in Assuit University
The kidneys of neonates are particularly susceptible to hypoperfusion because of the physiologic characteristics of neonatal kidneys, including high renal vascular resistance, high plasma renin activity, low glomerular filtration…
- Trial name
- NCT07083284
- Volunteers
- 100 people
- Sponsor
- Assiut University
Cardiac Surgery, Coronary Artery Bypass Grafting
Pharmacokinetics of AP214 Acetate in Patients Undergoing Cardiac Surgery
The purpose of the present research study is to investigate the pharmacokinetics, as well as safety, tolerability and pharmacodynamics of different ascending dosing regimens of AP214 in patients undergoing cardiac surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Grafting, Valve Surgery, Aortic Root or Ascending Aortic Aneurysm Repair Surgery
- Trial name
- NCT00903604
- Testing
- AP214
- Where
- 2 sites in Denmark
- Volunteers
- 42 people
- Sponsor
- Action Pharma A/S
Acute Kidney Injury, Renal Transplantation
Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients
Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant.
- Trial name
- DART-REIN (NCT06026592)
- Testing
- determination of circulating biomarkers of renal origin circulating biomarkers of renal origin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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