Clinical trials: Kidney; Disease, Acute
Fluid Overload, Hemodynamic Instability
Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy.
Net ultra filtration (NUF) is one of the most important parameters during renal replacement therapy (RRT) whose role is to control fluid balance by water removal.
- Trial name
- NEPTUNE (NCT06071026)
- Testing
- Net Ultra Filtration Rate
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury in Critically Ill Children
Utility of NGAL to Diagnose AKI in Critically Ill Children
Acute Kidney Injury is common in critically ill children and is associated with high morbidity and mortality in pediatric intensive care unit.
- Trial name
- NCT03034876
- Volunteers
- 140 people
- Sponsor
- Aga Khan University
Acute Kidney Injury, Surgery-Complications
Development of Synthetic Medical Data Generation Technology to Predict Postoperative Complications
<Development of synthetic medical data generation technology to predict postoperative complications> In order to develop a model for predicting the occurrence of complications after surgery, it is necessary to establish a cohort…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Nephropathy
- Trial name
- NCT05986474
- Where
- South Korea
- Volunteers
- 410,000 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Kidney Failure, Chronic
Relypsa For ED Acute Hyperkalemia Control and Reduction (REDUCE)
The Investigator hypothesize that a single dose of patiromer will lower serum potassium levels in less than 6hrs. Since a dosage of 30g/day for a period of 4 weeks has been studied in at least two multicenter randomized…
- Trial name
- NCT02933450
- Testing
- Patiromer 25.2 g
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Baylor College of Medicine
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
End Stage Renal Failure on Dialysis, Complication of Dialysis
A Prospective Study of Airless Tubing in an Inpatient Acute Hemodialysis Unit in Hospitalized Patients
The introduction of unfractionated heparin (UFH), which prevents clotting of the extracorporal circuit, was one of the key advances that led to the rapid development and expansion of hemodialysis services.
- Conditions
- End Stage Renal Failure on Dialysis, Complication of Dialysis, Blood Coagulation Disorders
- Trial name
- NCT02086682
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Marie Hogan
Acute Kidney Injury
Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
The patients discharged from intensive care units (ICU) have a high incidence of cardiovascular events and mortality rate during the year following ICU discharge.
- Trial name
- START-or-NOT (NCT05272878)
- Testing
- IRBESARTAN, tablet, 150 mg
- Where
- France
- Volunteers
- 508 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Incidince of Acute Kidney Injury in Children With Community Acquired Pneumonia at Assiut University Children Hospital
Descriptive prospective observational study of Incidince of acute kidney injury in children with community acquired pneumonia at assiut university children hospital
- Trial name
- NCT06117826
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury, VExUS
Doppler Evaluation for Congestive Acute Kidney Injury in Critical Illness
This study will evaluate the use of the Venous Excess Ultrasound (VExUS) score to guide fluid management in critically ill ICU patients through a prospective, multi-aim design combining observational and randomized components.
- Trial name
- DECONGEST-AKI (NCT07291778)
- Testing
- Fluid Management, No intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Severe Sepsis, Septic Shock
Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?
Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients.
- Conditions
- Severe Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT02034240
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Sygehus Lillebaelt
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
AKI - Acute Kidney Injury, Pneumonia
To Compare the Efficacy and Safety of Using oXiris and M100 During CRRT
The purpose of this study aimed to compare the efficacy of Oxiris (Baxter) and M100 filters on IL-6 as primary outcomes and other blood cell counts, blood biochemistry (serum urea, creatinine, potassium, sodium), inflammation…
- Trial name
- NCT06440759
- Testing
- oXiris filter, M100 filter
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
Acute Kidney Injury
Acute Kidney Injury In Care Transitions (ACT): Pragmatic Clinical Trial
The purpose of this study is to determine the effect of a multidisciplinary intervention at care transitions for acute kidney injury survivors on patient-centered outcomes.
- Trial name
- ACT (NCT07670520)
- Testing
- Acute Kidney Injury in Care Transitions (ACT), Usual Care
- Where
- 3 sites in United States
- Volunteers
- 2,260 people
- Sponsor
- Mayo Clinic
Acute Kidney Injury
Efficacy and Safety of Deferiprone in Patients With Chronic Kidney Disease Undergoing a Cardiac Catheterization and Receiving Contrast Agent
This trial will evaluate whether treatment with CRMD001 (unique formulations of the iron chelator, Deferiprone) will reduce morbidity and mortality in subjects with Chronic Kidney Disease (CKD) and additional risk factors.
- Trial name
- NCT01391520
- Testing
- deferiprone
- Sponsor
- CorMedix Therapeutics
Urolithiasis, Urologic Diseases
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis
To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or…
- Conditions
- Urolithiasis, Urologic Diseases, Urinary Calculi, Urinary Obstruction
- Trial name
- STONE (NCT04594161)
- Testing
- Percutaneous Nephrostomy, Double J catheter
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Kidney Injury, Acute Kidney Injury (AKI)
Hamburg Acute Kidney Injury Study (HAKIS)
The Hamburg Acute Kidney Injury Study (HAKIS) is a prospective observational cohort study aimed at investigating the mechanisms, risk factors, and clinical determinants of acute kidney injury (AKI) trajectories and consequences.
- Trial name
- HAKIS (NCT07338669)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiac Surgery, Cardiopulmonary Bypass
REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)
In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Renal Transplant Recipient
- Trial name
- RETROCAR (NCT04979754)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
Renal Colic
Lornoxicam With Low Dose Ketamine Versus Pethidine to Control Pain of Acute Renal Colic
Patients with acute renal colic divided into 2 groups. Group L administered ornoxicam and Group P administered pethidine and VAS was recorded for both groups.
- Trial name
- NCT03780556
- Testing
- Lornoxicam and mepridine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Kidney Failure
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
The aim of this study is to measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI.
- Trial name
- NCT02470520
- Testing
- CRRT
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust