Clinical trials: Kidney; Disease, Acute
Acute Coronary Syndrome
Protective Effect of Early High Dose stATins On Cardiovascular and Renal Events in Acute Coronary Syndrome
Registration of all ACS patients (STEMI and NSTEMI) admitted to the cardiology ward and scheduled for early invasive strategy. The aim is to evaluate the protective effects of early (on admission) high-dose high-potency statin…
- Trial name
- PRATO-ACS (NCT04087200)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Centro Cardiopatici Toscani
Acute Kidney Injury
Acute Kidney Injury After Elective Total Joint Arthroplasty
Total joint arthroplasty (TJA) is a common orthopedic procedure to treat patients with end-stage knee arthritis. Over 4,000 TJA were performed in the Hong Kong public hospitals in the past 12 months (July 2020 - June 2021) and…
- Trial name
- NCT05595694
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 1,077 people
- Sponsor
- The University of Hong Kong
Ischemic Preconditioning, Acute Kidney Injury
Remote Ischemic Preconditioning During Lower Limb Revascularization
The aim of this study is to evaluate the role of remote ischemic preconditioning (RIPC) in preventing acute kidney injury after lower limb revascularization.
- Conditions
- Ischemic Preconditioning, Acute Kidney Injury, Limb Ischemia
- Trial name
- NCT04016857
- Testing
- RIPC, Control
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
Induced Acute Kidney Injury, High-risk Percutaneous Coronary Intervention
Protect Kidney Trial
This trial is a randomized, controlled, open-label, parallel study. Patients at high risk for contrast induced acute kidney injury (CI AKI) and planned high-risk percutaneous coronary intervention (PCI) will be randomized to…
- Trial name
- NCT04321148
- Testing
- standard of care PCI, Impella-protected PCI
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
COVID-19, Lung Injury, Acute
SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI)
This study will evaluate the safety of a 96-hour intravenous vitamin C infusion protocol (50 mg/kg every 6 hours) in patients with hypoxemia and suspected COVID-19.
- Conditions
- COVID-19, Lung Injury, Acute, Kidney Injury
- Trial name
- NCT04344184
- Testing
- L-ascorbic acid
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Virginia Commonwealth University
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Chest Pain
Copeptin Testing During Pre-hospital Care in the Treatment of Chest Pain Suggestive of Acute Coronary Syndrome
The main objective of our study is to evaluate the diagnostic value of copeptin testing in association with troponin HS testing during pre-hospital care (ambulance care) in the treatment of patients whose pattern of use is the…
- Trial name
- SCA COP (NCT02116426)
- Testing
- Blood work in the ambulance, Blood work upon arrival in the emergency room, Blood work at 3 hours post-arrival in the emergency room
- Where
- 2 sites in France
- Volunteers
- 320 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Kidney Injury
Tolerability and Background Fluorescence of the MediBeacon Transdermal GFR Measurement System
This study is designed to evaluate background fluorescence of participants of different ages, gender, and skin color. In addition, 48-hour tolerability of the sensor and adhesive will be evaluated.
- Trial name
- NCT03810833
- Testing
- Brilliance device sensor
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Acute Renal Injury, Critical Illness
Acute Kidney Injury in Intensive Care Patients
The goal of this prospective observational study is to evaluate the incidence, risk factors, and outcomes for development of acute kidney injury (AKI) in intensive care pateints.
- Trial name
- AKI-ICU (NCT05970952)
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people
- Sponsor
- Haseki Training and Research Hospital
Acute Kidney Injury
Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury
The risk for postoperative acute kidney injury (pAKI), as for any other postoperative complications (PC), comes from a number of interactions between a patient's health before surgery, strength to tolerate surgery and influences…
- Trial name
- NavigateAKI (NCT02114138)
- Testing
- pathogenesis of perioperative acute kidney injury, urine collection
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Florida
AKI
Deep Learning Model and Risk Factors for Tacrolimus-related Acute Kidney Injury
In this study, the investigators aim to develop a risk prediction model for acute kidney injury (AKI) in hospitalized patients using the calcineurin inhibitor tacrolimus.
- Trial name
- NCT06596798
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Cardiac Surgery, Vasoplegia
Reducing Acute Kidney Injury Occurence by Administering Angiotensin II
The aim of this study is to evaluate whether adding angiotensin II to the standard of care is superior compared to the standard of care alone with respect to kidney damage (personalized approach) after cardiac surgery.
- Conditions
- Cardiac Surgery, Vasoplegia, Hyperreninemia
- Trial name
- AIDED (NCT05199493)
- Testing
- Angiotensin II, Control
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Universität Münster
Heart Failure
Effects of Acute and Chronic Empagliflozin Heart Failure
This is a 60-patient randomized, double-blind, placebo-controlled mechanistic study to understand the utility of empagliflozin in worsening heart failure (HF) patients with or without diabetes.
- Trial name
- EMPA HF (NCT05553938)
- Testing
- Empagliflozin 10 mg
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Acute Kidney Failure Stage 3, Continuous Renal Replacement Therapy (CRRT)
Effect of High Versus Standard Protein Intake in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy
During critical illness, patients experience a hypercatabolic state. This hypercatabolic state causes muscle wasting in patients, resulting in intensive care unit acquired weakness (ICU-AW).
- Trial name
- PROTEIN-CRRT (NCT07596043)
- Testing
- High protein group, Standard protein group
- Where
- Thailand
- Volunteers
- 56 people
- Sponsor
- Chulalongkorn University
Renal Failure
Uremic Toxins in the ICU: Patients After Cardiac Surgery
Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients after cardiac surgery.The sampling of blood and dialysate will be done during dialyses with…
- Trial name
- NCT00752804
- Testing
- Dialysis during 4 hours, Dialysis during 6 hours, Dialysis during 8 hours
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- University Hospital, Ghent
Geriatrics, Acute Renal Injury
Postoperative Kidney Functions in Geriatric Major Gynecologic-Oncologic Surgery
The increasing number of patients who develop perioperative acute kidney injury (AKI) is partly related to the aging population and the increasing number of individuals with chronic comorbidities, particularly those with…
- Conditions
- Geriatrics, Acute Renal Injury, Gynecologic Surgery
- Trial name
- NCT05308810
- Testing
- Major Gynecologic- oncologic Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara City Hospital Bilkent
Acute Kidney Injury
Acute Kidney Injury in Premature Infants
Our first Aim is to describe how common a sudden decrease in renal function happens in premature infants in a neonatal intensive care unit. We also want to see how a sudden loss of renal function affects survival.
- Trial name
- NCT00573079
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Alabama at Birmingham
Sepsis, Acute Kidney Injury Due to Sepsis
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction
In the present study, 126 patients were enrolled (23 control, 38 non-septic and 65 septic patients). Blood samples were collected from septic patients at the intensive care unit (ICU) at three time points (T1-3): T1: within 12h…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Septic Shock, Acute Respiratory Distress Syndrome
- Trial name
- NCT05060679
- Testing
- Supportive therapy at the ICU, Sepsis therapy, Sepsis-related organ dysfunction therapy
- Where
- Hungary
- Volunteers
- 126 people
- Sponsor
- University of Pecs
Acute Kidney Injury, Adverse Drug Event
Melatonin for Prevention of Kidney Injury
This study will evaluate the safety and effectiveness of melatonin for the prevention of antibiotic associated acute kidney injury in hospitalized patients.
- Trial name
- NCT05084196
- Testing
- Melatonin
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Rutgers, The State University of New Jersey
Acute Kidney Injury (Nontraumatic), Dialysis; Complications
WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy.
- Trial name
- WISDOM UK (NCT07447791)
- Testing
- low intensity of CRRT, usual intensity of CRRT
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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