Clinical trials: Kidney; Disease, Acute
Acute Kidney Injury
Evaluation of Novel Biomarkers From Acutely Ill Patients at Risk for Acute Kidney Injury
The purpose of this study is to collect blood and urine samples that may help identify and validate biomarkers for the early detection and risk assessment of acute kidney injury (AKI).
- Trial name
- NCT01209169
- Where
- 35 sites in United States, Austria and 6 more
- Volunteers
- 890 people
- Sponsor
- Astute Medical, Inc.
Acute Kidney Injury
AKI Management Using Electronic Alerts
Acute kidney injury (AKI) is a common clinical event with severe consequences. In the United States alone, greater than one million hospitalized patients per year are diagnosed with AKI.
- Trial name
- NCT03538769
- Testing
- electronic alert and clinical decision support system
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Seattle Children's Hospital
Thoracic Aortic Aneurysms, Dissecting, Aneurysm
Endovascular Treatment of Thoracic Aortic Disease
The purpose of this study is to assess the role endovascular therapy to treat aortic disease involving the ascending aorta, the aortic arch, and the visceral segment of the aorta (or thoracoabdominal aorta)
- Conditions
- Thoracic Aortic Aneurysms, Dissecting, Aneurysm, Ascending Aorta Aneurysm, Aortic Arch; Aneurysm, Dissecting
- Trial name
- EVOLVE Aorta (NCT00583817)
- Testing
- Endovascular stent-graft implantation
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Matthew Eagleton
Head and Neck Cancer
A Prospective Observational Study to Evaluate Acute Kidney Injury Biomarkers In Patients Receiving First Cycle of Cisplatin Chemotherapy for Head and Neck Cancers
The project is designed to test new biomarkers that are more sensitive than the current standard in detecting injury to the proximal kidney tubule and will establish better criteria for when kidney safety concerns may halt…
- Trial name
- NCT01936376
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Foundation for the National Institutes of Health
Heart Failure, Acute Heart Failure
PURE-HF: Peripheral Ultrafiltration for the RElief From Congestion in Heart Failure
This study evaluates whether tailored, peripheral ultrafiltration complementary to low-dose diuretics is associated with a reduction in cardiovascular mortality in 90 days after randomization and heart failure events in 90 days…
- Trial name
- NCT03161158
- Testing
- CHIARA-System, Usual care IV diuretics
- Where
- 11 sites in Germany, Sweden
- Volunteers
- 62 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Myocardial Infarction, Acute Kidney Injury
Sodium Bicarbonate and N-Acetylcysteine for Nephroprotection in Acute Myocardial Infarction
Contrast-induced nephropathy (CIN) represents a potential complication of diagnostic and therapeutic procedures in interventional cardiology, especially in the acute setting of primary PCI.
- Trial name
- BINARIO (NCT01218178)
- Testing
- Sodium bicarbonate plus NAC, Saline hydration plus NAC
- Where
- Italy
- Volunteers
- 520 people
- Sponsor
- Catholic University of the Sacred Heart
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Proton Pump Inhibitor, Acute Kidney Injury
Risk Factors and Machine Learning Model for Proton Pump Inhibitor Related Acute Kidney Injury
Recent evidence concerns acute kidney injury (AKI) following proton pump inhibitor (PPI) application. Few actual studies have compared the incidence, risk factors, and predictive models of AKI associated with PPI.
- Trial name
- NCT05533619
- Testing
- Proton pump inhibitor
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Qianfoshan Hospital
Intra Abdominal Infections, Appendicitis Acute
Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study
The NATURAL Study is a prospective, observational, pragmatic study of RNA biomarkers of infections to aid in the diagnosis of abdominal pain.
- Conditions
- Intra Abdominal Infections, Appendicitis Acute, Pyelonephritis, Diverticulitis
- Trial name
- NATURAL (NCT07579312)
- Testing
- TruNAV, an RNA-based blood test for host immune activation by infections
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- True Bearing Diagnostics, Inc.
Cardiogenic Shock, Acute Decompensated Heart Failure
SURPASS Impella 5.5 Study
A multi-center, prospective \& retrospective, observational single-arm study of the clinical outcomes up to one year collected from electronic health records of patients which have undergone standard of care implantation of…
- Trial name
- NCT05100836
- Testing
- Impella 5.5
- Where
- 15 sites in United States
- Volunteers
- 1,017 people
- Sponsor
- Abiomed Inc.
Acute Decompensated Heart Failure, Acute Kidney Injury
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
AKINESIS is a clinical study to assess the utility of blood and urine NGAL tests in predicting worsening kidney function in patients who present with acute heart failure (AHF) and who are treated with diuretics.
- Trial name
- AKINESIS (NCT01291836)
- Where
- 13 sites in United States, Greece and 5 more
- Volunteers
- 930 people
- Sponsor
- Alere San Diego
Acute Kidney Injury, Critical Illness
Citrate Anticoagulation for Postdilution Hemofiltration
This study evaluates a protocol for regional citrate anticoagulation in critically ill patients with acute kidney injury who are treated with continuous veno-venous haemofiltration in postdilution mode.
- Trial name
- CIPOHA (NCT03969966)
- Testing
- renal replacement therapy as clinically indicated
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Kidney Injury, Acute
Effects of Continuous Veno-venous Haemofiltration on Plasma Lactate in Critically Ill Patients
Continuous Veno-Venous Hemofiltration (CVVH) can eliminate metabolic products effectively and replace renal function partly. It is widely used in intensive care units (ICUs), especially for patients with acute kidney…
- Trial name
- NCT01824771
- Testing
- Plasma lactate were measured
- Where
- China
- Volunteers
- 15 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Contrast Induced Acute Kidney Injury
The Effect of Remote Ischemic Preconditioning on Elective Percutaneous Coronary Intervention in Diabetic Nephropathy
Contrast-induced acute kidney injury (CI-AKI) is a significant iatrogenic complication of contrast media use associated with prolonged hospitalization, cardiovascular events, persistent kidney damage and increased risk of…
- Trial name
- NCT02329444
- Testing
- Remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Ulsan University Hospital
Acute Pancreatitis
Early High-volume Continuous Veno-venous Hemofiltration for Patients With Severe Acute Pancreatitis
The purpose of this study is to determine the effect and safety of early high-volume continuous veno-venous hemofiltration for patients with severe acute pancreatitis.
- Trial name
- EHVCVVHSAP (NCT01595672)
- Testing
- AN69 hemofilter, conventional treatments
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Air Force Military Medical University, China
Acute Renal Failure on Dialysis (Disorder)
Prescription-based Fluid Management Versus Usual Care in Critically Ill Patients on KRT Trial in UK
The PROBE Fluid UK randomised controlled trial compares a protocol-based fluid removal strategy with usual care in critically ill patients with acute kidney injury receiving kidney replacement therapy.
- Trial name
- PROBE Fluid UK (NCT06471777)
- Testing
- Fluid removal
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Kidney Injury
Study of the Incidence and Prognosis of Intrahospital Acute Kidney Injury
The goal of this observational study is to investigate the epidemiology of acute kidney injury in hospitalized patients. The main question it aims to answer is: how frequent is the development of acute kidney injury in patients…
- Trial name
- SIPARIO-1 (NCT06697730)
- Where
- Italy
- Volunteers
- 43,000 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Acute Kidney Injury, Cardiorenal Syndrome
Renal Venous Flow and Cardiac Surgery-associated Acute Kidney Injury
The prospective single-center study investigates the association between changes in Doppler-derived renal venous flow and cardiac surgery-associated acute kidney injury (CSA-AKI).
- Trial name
- NCT03753607
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Giessen
Contrast Induced Nephropathy, Acute Renal Failure
Cystatin C as an Early Marker of Contrast-Medium Nephropathy in Cardiac Catheterization Patients
Hypothesis: Cystatin C compared with creatinine is a better and earlier marker of contrast-induced nephropathy in high and intermedium risk cardiac catheterization patients.
- Trial name
- NCT00467311
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- National Heart Institute, Mexico
Renal Insufficiency, Acute
Determination of the "Tissue Transit Time" (TTT)
Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty
- Trial name
- NCT03311256
- Testing
- Tissue Transit Time
- Where
- 9 sites in Germany, Switzerland
- Volunteers
- 119 people
- Sponsor
- University Hospital Tuebingen
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