Clinical trials: Kidney; Disease, Acute
Covid19, Acute Kidney Injury
Acute Kidney Injury in Patients With CoVID-19
We aimed to investigate the effect of Acute Kidney Injury (AKİ) on the prognosis of patients hospitalised for COVID-19.
- Trial name
- AKI-COVID-19 (NCT04872764)
- Testing
- duration of hospitalization, mortality rate
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Uşak University
Contrast-Induced Nephropathy, Acute Myocardial Infarction
Contrast Nephropathy Prevention With N-Acetylcysteine in Acute Myocardial Infarction
Patients with acute myocardial infarction undergoing primary angioplasty are at high risk for renal injury due to the toxic effect of contrast agents.
- Trial name
- NCT00237614
- Testing
- intravenous and oral N-acetylcysteine
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Acute Decompensated Heart Failure
Dopamine in Acute Decompensated Heart Failure II
The aim of this study is to compare the effects of 1) high-dose furosemide, 2) low-dose furosemide, and 3) low-dose furosemide combined with low-dose dopamine on diuresis, clinical status, renal function, electrolyte balance…
- Trial name
- DAD-HF II (NCT01060293)
- Testing
- High-dose furosemide, Low-dose furosemide, Low-dose furosemide combined with low-dose dopamine
- Where
- 6 sites in United States, Greece
- Volunteers
- 161 people
- Sponsor
- Larissa University Hospital
Acute Coronary Syndrome
Atorvastatin Versus Rosuvastatin on Contrast Induced Acute Kidney Injury (PRATO-ACS 2)
The aim of the project is to compare the nephro-protective effects of high-dose atorvastatin and high-dose rosuvastatin on the incidence of Contrast Induced-Acute Kidney Injury in patients with non-ST-elevation acute coronary…
- Trial name
- PRATO-ACS-2 (NCT01870804)
- Testing
- Rosuvastatin, Atorvastatin
- Where
- Italy
- Volunteers
- 760 people
- Sponsor
- Centro Cardiopatici Toscani
Hypotension, Acute Kidney Injury
A Clinical Decision Support Trial to Reduce Intraoperative Hypotension
The purpose of this study is to provide messages to providers if their patient is at high risk of developing intraoperative hypotension based on past medical history and co-morbidities preoperatively and minutes of hypotension…
- Trial name
- NCT04062994
- Testing
- Nudge to reduce intraoperative hypotension
- Where
- 4 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- University of California, Los Angeles
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Citrate Toxicity, Regional Citrate Anticoagulation
Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRT
Citrate has been proposed as anticoagulation of choice in continuous renal replacement therapy (CRRT). However, little is known about the pharmacokinetics (PKs) and metabolism of citrate in liver failure patients who require CRRT…
- Conditions
- Citrate Toxicity, Regional Citrate Anticoagulation, Liver Failure, Acute, Liver Failure, Acute on Chronic
- Trial name
- Citrate PK (NCT04959110)
- Testing
- Pharmacokinetic study
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chulalongkorn University
Acute Kidney Injury
A Study of Auxora in Patients With AKI and Injurious Lung "Crosstalk"
Approximately 150 patients with acute kidney injury (AKI) associated with acute hypoxemic respiratory failure (AHRF) will be randomized at up to 40 sites. Patients will be randomly assigned to either Auxora or matching placebo.
- Trial name
- KOURAGE (NCT06374797)
- Testing
- Auxora
- Where
- 33 sites in United States
- Volunteers
- 122 people
- Sponsor
- CalciMedica, Inc.
Acute Kidney Injury
VIDAS Nephroclear (NCL) CCL14 - Sample Stability
This VIDAS® NEPHROCLEAR™ CCL14 (VIDAS® NCL™ CCL14) Sample Stability clinical trial is a multicenter, prospective, and qualitative study.
- Trial name
- NCT05271617
- Testing
- VIDAS® NEPHROCLEAR™ CCL14
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- BioMérieux
Acute Kidney Injury
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism
Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
- Trial name
- CAT-RISK (NCT07751874)
- Testing
- continuous renal replacement therapy with regional citrate anticoagulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Renal Replacement Therapy for Acute Kidney Injury in Intensive Care Unit
Artificial Kidney Initiation in Kidney Injury
The best timing for renal replacement therapy (RRT) in intensive care unit (ICU) patients with acute kidney injury (AKI) is unknown.
- Trial name
- AKIKI (NCT01932190)
- Testing
- Early RRT strategy, Delayed RRT strategy
- Where
- France
- Volunteers
- 620 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
AKI - Acute Kidney Injury
Venous Return Pressure Gradient as a Predictor of Acute Kidney Injury
Acute kidney injury (AKI) is a common and serious complication in the ICU. Current diagnostic indicators (such as creatinine and urine output) exhibit significant lag, and specific hemodynamic predictive markers are lacking.
- Trial name
- VRPG-AKI (NCT07722325)
- Testing
- No study intervention
- Volunteers
- 180 people
- Sponsor
- Sichuan Academy of Medical Sciences
Kidney Cancer, Leukemia
Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
RATIONALE: Glutamine may help lessen neuropathy caused by chemotherapy. It is not yet known whether glutamine is more effective than a placebo in treating neuropathy caused by vincristine.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00365768
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Columbia University
Pyelonephritis, Renal Scars
A Randomized Controlled Trial on Antibiotic Prophylaxis in Children With Vesico-Ureteral Reflux
The aim of this study is to assess the effectiveness of antibiotic prophylaxis in preventing pyelonephritis and in avoiding the appearance of new scars in a sample of children under 36 months with vesico-ureteral reflux (VUR).
- Trial name
- NCT00382343
- Testing
- Sulfamethoxazole/trimethoprim
- Where
- 7 sites in Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS Burlo Garofolo
Acute Kidney Injury
Hyperbaric Oxygen Therapy and Acute Kidney Injury
Kidney injury is a serious complication of cardiac surgery that occurs in up to 30% of patients and increases the risk of adverse outcomes.
- Trial name
- NCT02743754
- Testing
- Standard therapy, Hyperbaric Oxygen
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Childhood Cancer, Chronic Kidney Diseases
KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors (CCS)
Background: Childhood cancer survivors (CCS) are at elevated risk of chronic health conditions. Chemotherapies can cause recurrent acute kidney injury which may progress to kidney fibrosis, chronic kidney disease (CKD) or…
- Conditions
- Childhood Cancer, Chronic Kidney Diseases, Hypertension, Acute Kidney Injury
- Trial name
- KINDEST-CCS (NCT06153147)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- The Hospital for Sick Children
Renal Transplant Rejection, Pediatric Kidney Disease
VIRTUUS Children's Study
The objective of the VIRTUUS Children's Study is to adapt identified and validated adult noninvasive diagnostic and prognostic biomarkers for the characterization of allograft status in pediatric recipients of kidney allografts.
- Conditions
- Renal Transplant Rejection, Pediatric Kidney Disease, End Stage Renal Disease, Nephropathy
- Trial name
- VIRTUUS (NCT03719339)
- Where
- 13 sites in United States, Canada
- Volunteers
- 445 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
Decompensated Cirrhosis, Cirrhotic Cardiomyopathy
Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival
Cirrhosis and portal hypertension are associated with a hyperdynamic circulation and decompensation events, including development of ascites, variceal bleeding, acute kidney injury, and susceptibility to infections.
- Conditions
- Decompensated Cirrhosis, Cirrhotic Cardiomyopathy, Cirrhosis, Liver, Left Ventricular Diastolic Dysfunction
- Trial name
- CIRROSTAT (NCT06431919)
- Testing
- Simvastatin 20mg, Carvedilol 3.125 mg
- Where
- India
- Volunteers
- 260 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Kidney Injury
A Prompt REstart Study of Renin-Angiotensin System Inhibitors After Acute Kidney Injury
The goal of this pilot clinical trial is to learn if early restart of renin-angiotensin system inhibitor (RASi) medications is feasible and well-tolerated in hospitalized patients with acute kidney injury (AKI).
- Trial name
- APRES-AKI (NCT07734636)
- Testing
- Early RASi restart strategy, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
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