Clinical trials: Kidney; Disease, Acute
Congenital Heart Disease, Acute Kidney Injury
Effects of Anesthetic Techniques on Renal Function
This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
- Trial name
- NCT04030481
- Testing
- inhalation anesthesia, Total intravenous anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Malaria, Pyelonephritis
Contrast-Enhanced US of Spleen, Liver and Kidney
To evaluate the changes in the microcirculation of the liver, kidney and spleen during acute infection in patients with malaria (cohorts 1 and 3) and other infectious diseases such as acute pyelonephritis at day 0 (within 8 hours…
- Conditions
- Malaria, Pyelonephritis, Bacterial Infections
- Trial name
- NCT00190281
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Coronary Syndrome, Chronic Kidney Diseases
The Predictive and Diagnostic Value of Cystatin C and High Sensitive Troponin
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated.
- Trial name
- NCT05303441
- Testing
- percutaneous coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Ankara Diskapi Training and Research Hospital
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia
Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)
Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been…
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Acute Mesenteric Ischemia, Acute Kidney Injury, Non-Occlusive Mesenteric Ischaemia
- Trial name
- aMIKI (NCT06365827)
- Testing
- observational study
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Giessen
Acute Kidney Injury
Prevention of Akute Kidney Injury, Hearttransplant, ANP
Prospective, blinded, placebo-controlled trial. Patients: Adult patients (>18 years of age) undergoing de novo Htx, with a preoperative GFR > 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of > 6 hours.
- Trial name
- NCT02665377
- Testing
- ANP
- Where
- Sweden
- Volunteers
- 86 people
- Sponsor
- Sahlgrenska University Hospital
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University
Acute Pain
Vasopressin and Pain Perception in the Brain
The feeling of pain is not just a sensory experience, but is also influenced by emotions, beliefs and expectations, making pain a highly subjective experience.
- Trial name
- NCT03446456
- Testing
- Arginine vasopressin, Saline, Observational learning
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Complex Aortic Aneurysms, Thoracoabdominal Aneurysms
Complex Aortic Aneurysm Repair Using Physician Modified Endografts and Custom Made Devices
The purpose of this study is to evaluate the safety and efficacy of custom made devices, Zenith t-Branch devices and physician modification of FDA approved off-the-shelf endovascular grafts in the treatment of patients with…
- Conditions
- Complex Aortic Aneurysms, Thoracoabdominal Aneurysms, Pararenal Aneurysms, Juxtarenal Aneurysms
- Trial name
- CARPE-CMD (NCT02050113)
- Testing
- Custom Made Fenestrated or Branched Stent Graft
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Andres Schanzer
Chronic Kidney Diseases, Acute on Chronic Renal Failure
Effects of a Goal-Oriented Care Interventions
This study was a clinical trial. This study aimed to evaluate the effects of Goal-Oriented Care intervention on blood pressure, percentage of interdialytic weight gain, self-management behaviors, and quality of life in…
- Conditions
- Chronic Kidney Diseases, Acute on Chronic Renal Failure, Acute Kidney Injury
- Trial name
- NCT06068660
- Testing
- The Goal-Oriented Care program, The routine health education
- Where
- Taiwan
- Volunteers
- 92 people
- Sponsor
- Chang Gung Memorial Hospital
Acute Kidney Injury
Biomarker Rule in/Out in Patients With Acute Diseases for Validation of AKI (BRAVA) Acute Kidney Injury
The presence or development of AKI impacts on outcomes in patients presenting with acute conditions to the ED. As a result, treating physicians are often concerned with the risk of AKI and take such risk in consideration when…
- Trial name
- BRAVA (NCT03754023)
- Testing
- Urine-TIMP-IGFBP7 biomarker for AKI
- Where
- 5 sites in Australia, India and 3 more
- Volunteers
- 818 people
- Sponsor
- GREAT Network Italy
Contrast-induced Nephropathy, Acute Renal Failure
Prevention of Contrast-Induced Nephropathy
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram.
- Conditions
- Contrast-induced Nephropathy, Acute Renal Failure, Chronic Renal Failure
- Trial name
- NCT00175227
- Testing
- intravenous saline hydration + mannitol + furosemide, intravenous saline hydration
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Alberta
Acute Kidney Injury, Coronary Artery Disease
Renal Doppler Indices for Predicting Acute Kidney Injury After Isolated CABG
Acute kidney injury can occur after coronary artery bypass grafting (CABG). This prospective, single-center observational study will evaluate whether two measurements obtained from renal Doppler ultrasound-the renal augmented…
- Trial name
- NCT07821983
- Testing
- Renal Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Endothelial Dysfunction, Acute Kidney Injury
Optimizing Pulsatility During Cardiopulmonary Bypass
Cardiopulmonary bypass during cardiac surgery provides blood flow to the body during surgery but has adverse effects on different organs.
- Trial name
- NCT05344573
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Colorado, Denver
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Acute Coronary Syndrome, Acute Coronary Syndrome With Renal Dysfunction
Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction
The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).
- Trial name
- NCT04998227
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Decompensated Cirrhosis, AKI - Acute Kidney Injury
Study to Evaluate the Efficacy of Intravenous Administration of Human Albumin Versus Saline Solution in Patients With descompénsate Cirrhosis Grade 1B or Higher Renal Failure
This is a phase IV, unicentric, open-label. Patients eligible for this study will be patients with AKI 1B or greater and decompensated cirrhosis from the hospital participating in the study
- Trial name
- LIVER-AKI (NCT07270874)
- Testing
- Saline solution (NaCl 0.9%)
- Volunteers
- 114 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Acute Kidney Injury
Iatrogenic Deficiencies in ICU Patients With Prolonged Continuous Renal Replacement Therapy
ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.
- Trial name
- IBRIST (NCT06983197)
- Testing
- blood test
- Volunteers
- 30 people
- Sponsor
- Karolinska University Hospital
Acute Kidney Injury, Septic Shock
Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?
Sepsis is the most common cause of acute kidney injury (AKI) in critically ill patients and is associated with a high mortality rate. Currently there is no available specific treatment to prevent or treat AKI in this setting.
- Conditions
- Acute Kidney Injury, Septic Shock, Nicotinamide, Mortality
- Trial name
- VITAKI (NCT04589546)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 310 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Critically Ill, Cancer
Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients
Acute kidney injury frequently affects cancer patients. The main cause of acute kidney injury is ischemic damage caused by transient decrease in renal blood flow, followed by blood flow restoration and accompanying reperfusion…
- Trial name
- SPIROCAN (NCT02531412)
- Testing
- Spironolactone
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
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