Clinical trials: Kidney; Disease, Acute
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival.
- Trial name
- NCT04103307
- Testing
- Dialysis cooling
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute Kidney Injury
Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients
Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.
- Trial name
- NCT04130347
- Volunteers
- 499 people
- Sponsor
- Uppsala University
Acute Kidney Injury, Anemia
Urinary NGAL Acute Kidney Injury After Stored Red Blood Cells Transfusion in Critically Ill Patients.
The study aims to explore the association of the novel urinary bio marker NGAL with the age of PRBCs(packed red blood cells) transfusion in critically ill patients.
- Trial name
- NCT03560921
- Testing
- urinary NGAL
- Where
- Egypt
- Volunteers
- 147 people
- Sponsor
- Kasr El Aini Hospital
Diabetes Mellitus, Type 2
Post-authorisation Safety Study in Patients With Type 2 Diabetes to Assess the Risk of Liver Injury, Kidney Injury, Urinary Tract and Genital Infections, and Diabetic Ketoacidosis in Patients Treated With Empagliflozin, Compared to DPP-4 Inhibitors
Empagliflozin (Jardiance), a highly potent and selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2), was approved in Europe in May 2014 for the treatment of type 2 diabetes mellitus (T2DM) to improve glycaemic…
- Trial name
- NCT02864914
- Testing
- Empagliflozin, DPP-4 inhibitors
- Where
- United Kingdom
- Volunteers
- 333,580 people
- Sponsor
- Boehringer Ingelheim
Solid Tumors, Acute Kidney Injury
Mesenchymal Stem Cells In Cisplatin-Induced Acute Renal Failure In Patients With Solid Organ Cancers
This is a pilot, explorative, study to test the feasibility and safety of systemic infusion of donor ex-vivo expanded Mesenchymal Stem Cells to repair the kidney and improve function in patients with solid organ cancers who…
- Trial name
- CIS/MSC08 (NCT01275612)
- Testing
- Mesenchymal stromal cell infusion
- Where
- Italy
- Sponsor
- Mario Negri Institute for Pharmacological Research
Acute Kidney Injury, Cancer
Cisplatin Induced Kidney Toxicity
Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers.
- Trial name
- ACCENT (NCT04442516)
- Testing
- Questionnaire, sampling of blood, urine and saliva
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children
Acute Kidney Injury
Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: Intraoperative Transesophageal Ultrasound Doppler venous imaging can be used to…
- Trial name
- NCT05682716
- Testing
- Controlled low central venous pressure (CLCVP) technology, Nitroglycerin
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury
IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients
Intermittent hemodialysis (IHD) and continuous RRT (CRRT) provided as continuous hemofiltration or hemodiafiltration are the main RRT modalities in ICU.
- Trial name
- ICRAKI (NCT06032884)
- Testing
- continuous renal replacement therapy (CRRT), Intermittent hemodialysis (IHD)
- Where
- France
- Volunteers
- 554 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critically Ill, Acute Kidney Injury
Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Compared with AN69 hemofilter, AN69 ST hemofilter may prolong the time of hemofilter and decrease the quantity of heparin during continuous renal replacement therapy in critically ill.
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- NCT01823484
- Testing
- AN 69 ST hemofilter, AN 69 hemofilter
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
Shock
Impact of Amount of Fluid for Circulatory Resuscitation on Renal Function in Patients in Shock
Volume resuscitation is the mainstay of treatment in most types of shock, especially in hemorrhagic and septic shock. Septic shock is a main cause of morbidity and mortality worldwide.
- Trial name
- VoluKid (NCT02666404)
- Testing
- Measurement
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University Hospital, Basel, Switzerland
Acute-On-Chronic Liver Failure, Hepatorenal Syndrome
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
Acute on chronic liver failure (ACLF) is a distinct entity where, because of severe acute hepatic injury, a rapid loss of liver function develops in a patient with previous chronic liver disease(4).
- Conditions
- Acute-On-Chronic Liver Failure, Hepatorenal Syndrome, Acute Kidney Injury
- Trial name
- NCT04416282
- Testing
- Terlipressin, Albumin
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Ischemic Reperfusion Injury
Single-cycle Remote Ischemic Preconditioning and Postconditioning for Prevention of Contrast-Induced Nephropathy
This trial is a 2 x 2 factorial design, double-blinded, randomized controlled trial to evaluate efficacy and safety of remote ischemic preconditioning and postconditioning for prevention of contrast-induced acute kidney injury in…
- Trial name
- NCT02729155
- Testing
- RIPre, RIPost
- Where
- Thailand
- Volunteers
- 596 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Acute Ischemic Stroke, Contrast-induced Nephropathy
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment
This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).
- Conditions
- Acute Ischemic Stroke, Contrast-induced Nephropathy, Acute Kidney Injury
- Trial name
- NCT07546448
- Testing
- No intervention (observational cohort study)
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Sepsis-Related Mortality, Acute Kidney Injury
Predictive Value of the Uric Acid/Albumin Ratio and Lactate in Sepsis Patients
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units.
- Trial name
- NCT07332715
- Testing
- Non-interventional / Observational Study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Acute Kidney Injury, Liver Failure
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood Pressure
Comparing the effects of MAP 60, 75 and 90 mmHg, respectively, on renal blood flow, glomerular filtration rate and renal oxygen demand in patients with terminal liver failure directly after liver transplantation.
- Trial name
- NCT02455115
- Testing
- Alternating mean arterial pressure, Norepinephrine, Chromium ethylenediaminetetraacetic acid
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Sahlgrenska University Hospital
Chemotherapy Side Effects, Machine Learning
Prospective Validation of Machine Learning Model to Predict Platinum Induced Nephrotoxicity in Cancer Patients
This study aims to investigate the utility of predictive models for chemotherapy-induced nephrotoxicity in the Taiwanese cancer population.
- Conditions
- Chemotherapy Side Effects, Machine Learning, Acute Kidney Injury, Acute Kidney Disease
- Trial name
- NCT07114276
- Testing
- Machine learning models predictions of acute kidney injury and acute kidney disease
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Large Volume Resuscitation, Acute Kidney Injury
Resuscitation Fluid Choice and Clinical Outcomes
This observational study evaluates the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation.
- Conditions
- Large Volume Resuscitation, Acute Kidney Injury, Hyperchloremic Metabolic Acidosis
- Trial name
- NCT02641119
- Volunteers
- 65,800 people
- Sponsor
- University of Pittsburgh
SARS-CoV-2 Infection, Acute Kidney Injury
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
An interventional clinical trial using oral nicotinamide riboside (NR) in hospitalized patients with COVID-19 infection and acute kidney injury to determine the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+)…
- Trial name
- NIRVANA (NCT04818216)
- Testing
- Nicotinamide riboside
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Acute Kidney Injury, Adverse Drug Reaction
The Drug Induced Renal Injury Consortium
Some medications are known to cause kidney damage because the person is allergic to the medication while others cause direct damage to the kidney because they are toxic at certain concentrations.
- Conditions
- Acute Kidney Injury, Adverse Drug Reaction, Acute Kidney Failure, Kidney Failure
- Trial name
- DIRECT (NCT02159209)
- Where
- 18 sites in United States, Bolivia and 4 more
- Volunteers
- 634 people
- Sponsor
- Ravindra Mehta
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