Clinical trials: Kidney; Disease, Acute
Congestive Heart Failure
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT02047422
- Testing
- Furosemide, metolazone, furosemid/spironolactone
- Sponsor
- Yonsei University
Kidney Transplant; Complications, Diarrhoea;Acute
GastroIntestinal Panel in Kidney Transplant Patients
This project focuses on the evaluation of the impact of the rapid mutltiplex test on changes in anti-infectious treatments in kidney transplant patients with diarrhea.
- Conditions
- Kidney Transplant; Complications, Diarrhoea;Acute, Diarrhea Infectious
- Trial name
- GIPIK (NCT05722119)
- Testing
- FilmArray GI
- Volunteers
- 135 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury, Acute Interstitial Nephritis
Infliximab for Immune Checkpoint Inhibitor Associated AKI
This is a multi-center, 1:1 randomized pilot study examining the efficacy and safety of infliximab 5mg/kg x 1 paired with 2 weeks of prednisone 1mg/kg per day for 2 weeks versus standard-of-care glucocorticoid therapy (prednisone…
- Trial name
- NCT07683975
- Testing
- Infliximab, Prednisone, prednisone (oral)
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Massachusetts General Hospital
Postoperative Complications
Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment
Brief Summary: The goal of this study is to implement and test an intelligent perioperative system (IPS) that in real-time predicts risk for postoperative complications using routine clinical data collected in electronic health…
- Trial name
- IDEALIST (NCT02741986)
- Testing
- Risk estimation
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Heart Failure
Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients
This is a multicenter, randomized, double-blind, placebo-controlled study to assess safety, tolerability and pharmacokinetics and to explore efficacy of IV infusion of 10 µg/kg/day and 30 µg/kg/day serelaxin for 48 hours compared…
- Trial name
- NCT02002702
- Testing
- Serelaxin
- Where
- 15 sites in Japan
- Volunteers
- 46 people
- Sponsor
- Novartis Pharmaceuticals
Acute Kidney Injury, Abdominal Aortic Aneurysm
Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair
The purpose of this program of research is to determine whether curcumin, a natural health product, can prevent acute kidney injury and other complications after elective AAA repair.
- Trial name
- NCT01225094
- Testing
- curcumin
- Where
- 10 sites in Canada
- Volunteers
- 606 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
AKI, AKI - Acute Kidney Injury
Outpatient Recovery From Acute Kidney Injury Requiring Dialysis - 2
Providing additional information to patients with acute kidney injury who continue dialysis after hospital discharge and to the accepting kidney doctor (nephrologist) who manages their dialysis may be feasible and beneficial.
- Conditions
- AKI, AKI - Acute Kidney Injury, Dialysis Patients
- Trial name
- ORKID-2 (NCT07106151)
- Testing
- Transmission of additional AKI-D recovery information, No additional AKI-D recovery information
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Hypertension, Renovascular, Renal Artery Stenosis
Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS)
Aims assessment of renal artery stenosis incidence in consecutive AMI patients included in the Romanian National Programme of Primary Percutaneous Revascularisation; generating a cardio-renal-metabolic profile in patients with…
- Conditions
- Hypertension, Renovascular, Renal Artery Stenosis, Myocardial Infarction
- Trial name
- REN-ACS (NCT02388139)
- Testing
- renal artery angiography, coronarography, coronary angioplasty
- Where
- Romania
- Volunteers
- 200 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Acute Kidney Injury
Neutrophil Gelatinase-associated Lipocalin in Major Abdominal Surgery
Acute kidney injury (AKI) after major surgery is a well-known complication. The incidence of AKI after major surgery ranges from 13% to 50%.
- Trial name
- NCT05721638
- Testing
- Neutrophil gelatinase-associated lipocalin
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Antalya Training and Research Hospital
Dialysis, Critically Ill Acute Kidney Injury
Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America
This is an international, multicenter, observational study aimed at investigating acute kidney injury requiring renal replacement therapy (AKI-RRT) in Latin American countries.
- Conditions
- Dialysis, Critically Ill Acute Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU, Acute Kidney Injury
- Trial name
- LATAM-AKID (NCT07262320)
- Where
- 15 sites in Bolivia, Brazil and 7 more
- Volunteers
- 1,000 people
- Sponsor
- University of Alabama at Birmingham
End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis
EXtension of Tablo TrEatmeNt Duration Registry
Observational, retrospective and prospective, multicenter, post-market study of the Tablo Hemodialysis System in hospitalized participants with End-Stage Kidney Disease or Acute Kidney Injury who are prescribed renal replacement…
- Conditions
- End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis, Acute Kidney Injury
- Trial name
- XTEND (NCT04912050)
- Testing
- Tablo Hemodialysis System
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Outset Medical
Acute Kidney Injury
A Study to Evaluate the Safety and Feasibility of Continuous Renal Replacement Therapy With Regional Citrate Anticoagulation in a Cohort Critical Ill Patients With Acute Kidney Injury and Presumed Absent Citrate Metabolism
Use of regional citrate anticoagulation in an at risk population with decreased citrate metabolism. This study assesses the feasibility and safety of regional citrate anticoagulation in this population.
- Trial name
- CAT-RISK (NCT07751874)
- Testing
- continuous renal replacement therapy with regional citrate anticoagulation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Acute Kidney Injury
Investigations Into Sepsis-associated Acute Kidney Injury
In this study the investigators would like to study systemic and regional disturbances in patients with sepsis-associated acute kidney injury and in healthy controls undergoing laparoscopic abdominal surgery.
- Trial name
- NCT05694624
- Testing
- Para Aminohippurate
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University Hospital of North Norway
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Liver Cirrhosis, Acute Kidney Injury
To Study Efficacy of Albumin in Cirrhosis With Spontaneous Bacterial Peritonitis at Low Risk for AKI Development
The role of Albumin in prevention and Treatment of Acute Kidney Injury (AKI) in patients with Spontaneous Bacterial Peritonitis (SBP) who are at high risk of AKI development has been clearly defined , which decreases the…
- Trial name
- NCT04437810
- Testing
- Albumin, Standard Medical Treatment
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cancer
Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections
RATIONALE: White blood cells that have been treated in the laboratory may kill cells that are infected with cytomegalovirus. PURPOSE: This phase I trial is studying how well cytotoxic T cells work in treating patients who have…
- Trial name
- NCT00769613
- Testing
- cytomegalovirus IE-1-specific cytotoxic T lymphocytes, cytomegalovirus pp65-specific cytotoxic T lymphocytes, therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Acute Kidney Injuries
the Percent of AKI Occurred in Patient With Comorbidities Undergoing Colonoscopy
observation the percent AKI in patient with comorbidities undergoing colonoscopy
- Trial name
- NCT06743815
- Volunteers
- 113 people
- Sponsor
- Assiut University
Acute Kidney Injury
Effectiveness-Implementation Evaluation of Acute Kidney Injury Decision Support
Study Purpose: This study is testing an artificial intelligence (AI)-powered clinical decision support (CDS) system designed to help emergency department (ED) doctors detect and manage acute kidney injury (AKI) earlier.
- Trial name
- SMART-AKI (NCT06840210)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- Johns Hopkins University
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