Clinical trials: Kidney (Renal Cell) Cancer
Renal Cell Carcinoma
Sorafenib and RAD001 Renal Cell Carcinoma
The objective of the phase I part of the study is to determine the maximum tolerated dose and dose limiting toxicities of the combination of RAD001 and sorafenib in patients with untreated metastatic kidney cancer.
- Trial name
- NCT00384969
- Testing
- RAD001 and Sorafenib
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of California, San Francisco
Renal Cell Cancer Metastatic, Hypertension
Sunitinib Treatment on Tissue Sodium Accumulation (TSS2)
Here, it is investigated how sunitinib, a tyrosine kinase-inhibitor targeting vascular endothelial growth factor receptors, might influence sodium homeostasis in the skin and if this is related to a well-described treatment…
- Conditions
- Renal Cell Cancer Metastatic, Hypertension, Sodium Imbalance
- Trial name
- NCT04368546
- Testing
- Sunitinib
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Urothelial Carcinoma
BIBF1120 in Patients With Advanced FGFR3 Mutated,Overexpressed,or Wild Type Urothelial Carcinoma
BIBF1120 in patients with advanced FGFR3 mutated, FGFR3 overexpressed, or FGFR3 wild type urothelial carcinoma of urinary bladder, urethra, ureter, and renal pelvis and who have failed platinum-based chemotherapy.
- Trial name
- NCT02278978
- Testing
- BIBF1120
- Where
- Taiwan
- Volunteers
- 129 people
- Sponsor
- National Taiwan University Hospital
Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter
Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers
This randomized clinical trial studies the Family Caregiver Palliative Care Intervention in supporting caregivers of patients with stage II-IV gastrointestinal, gynecologic, urologic and lung cancers.
- Conditions
- Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter, Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter, Psychosocial Effects of Cancer and Its Treatment
- Trial name
- NCT01846520
- Testing
- educational intervention, telephone-based intervention, quality-of-life assessment
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Renal Cell Carcinoma
Imaging Correlates of Renal Cell Carcinoma Biological Features
This pilot study is designed to evaluate imaging parameters indicative of underlying tumor biology. Patients with large renal masses (>3 cm, or at the discretion of the investigator) who are planning to undergo nephrectomy will…
- Trial name
- NCT01665703
- Testing
- FDG PET/MR
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8
Immunophenotyping in Metastatic Kidney Cancer Patients Receiving Ablative Therapy
This early phase I trial evaluates blood samples to see if patients undergoing standard of care treatment with either stereotactic body radiation therapy or percutaneous ablation (using radio waves to create heat to destroy the…
- Trial name
- NCT05112627
- Testing
- Biospecimen Collection
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Melanoma, Carcinoma, Renal Cell
A Phase I Study of Intravenous Recombinant Human IL-15 in Adults With Refractory Metastatic Malignant Melanoma and Metastatic Renal Cell Cancer
Background: Recombinant human interleukin-15 (rhIL-15) is a substance that is naturally produced in the body that has many properties that increase the activity and strength of the immune system, the body s natural defense…
- Trial name
- NCT01021059
- Testing
- rh IL-15
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Renal Cell Carcinoma
Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma
detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.
- Trial name
- NCT04873180
- Testing
- sectioning and staining of renal neoplasms after nephrectomy operation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Cutaneous Malignant Melanoma, Renal Cell Cancer
Low-Dose-Rate Brachytherapy Combined With Immune Checkpoint Inhibition in Cancer
This is a pilot study of combination low dose rate brachytherapy (LDR) added to standard of care (SOC) immunotherapy in stage III and IV melanoma, stage IV renal call cancer, and stage IV urothelial cancer.
- Conditions
- Cutaneous Malignant Melanoma, Renal Cell Cancer, Urothelial Cancer of Renal Pelvis
- Trial name
- NCT04620603
- Testing
- Low Dose Rate Brachytherapy (LDR), Standard-of-Care Immunotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Gastrointestinal Stromal Tumors, Small-cell Lung Cancer
A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit
This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.
- Conditions
- Gastrointestinal Stromal Tumors, Small-cell Lung Cancer, Adenoid Cystic Carcinoma, Uveal Melanoma
- Trial name
- NCT06805825
- Testing
- NN3201
- Where
- 5 sites in United States
- Volunteers
- 67 people
- Sponsor
- Novelty Nobility, Inc.
Breast Neoplasms, Prostate Neoplasms
PF-06952229 Treatment in Adult Patients With Advanced Solid Tumors
A Phase 1 dose escalation and expansion study evaluating safety, tolerability and pharmacokinetics of PF-06952229 in adult patients with advanced solid tumors.
- Conditions
- Breast Neoplasms, Prostate Neoplasms, Neoplasms, Squamous Cell, Melanoma
- Trial name
- NCT03685591
- Testing
- PF-06952229, Enzalutamide
- Where
- 15 sites in United States
- Volunteers
- 49 people
- Sponsor
- Pfizer
Epithelial Ovarian Cancer, Renal Cell Carcinoma
HKT288 in Solid Tumors, Including Epithelial Ovarian Cancer and Renal Cell Carcinoma
A first-in-human study using HKT288 in solid tumors, including epithelial ovarian cancer and renal cell carcinoma
- Trial name
- NCT02947152
- Testing
- HKT288
- Where
- 6 sites in United States, Australia and 4 more
- Volunteers
- 9 people
- Sponsor
- Novartis Pharmaceuticals
Advanced Non-Clear Cell Kidney Cancer
Study of Atezolizumab + Bevacizumab in Patients With Advanced Non-Clear Cell Renal Cell Carcinoma
This research study is studying the combination of Atezolizumab and Bevacizumab as a possible treatment for Advanced Non-Clear Cell Kidney Cancer.
- Trial name
- NCT02724878
- Testing
- Bevacizumab, Atezolizumab
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- Dana-Farber Cancer Institute
Kidney Cancer
Sunitinib as First-Line Therapy in Treating Patients With Locally Advanced Metastatic Papillary Renal Cell Cancer
RATIONALE: Sunitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00541008
- Testing
- sunitinib malate
- Where
- 22 sites in France
- Volunteers
- 92 people
- Sponsor
- UNICANCER
Cancer
Prevention of Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation
RATIONALE: Bone marrow transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill tumor cells.
- Trial name
- NCT00003538
- Testing
- graft versus host disease prophylaxis/therapy, allogeneic bone marrow transplantation
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Renal Cell Carcinoma
Duration of Treatment With Tyrosine Kinase Inhibitors in the Treatment of Metastatic Renal Cell Carcinoma
This study is a prospective, non-interventional, non-controlled, multi-center, observational cohort study. The medication is prescribed within the regular practice of the physician.
- Trial name
- TURCOS (NCT01585974)
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 151 people
- Sponsor
- Bayer
Renal Cell Cancer
Bortezomib and Bevacizumab ("BB-mib-mab") in Patients With Advanced or Recurrent Renal Cell Cancer (RCC)
This research study is for subjects with cancer of the kidney (also known as renal cell carcinoma) that cannot be treated with surgery.
- Trial name
- NCT00184015
- Testing
- Bevacizumab and Bortezomib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Pediatric ALL, Stone, Urinary
Indications and Outcomes in Kidney-ureteral Pediatric Lithiasis: Experience of Parma
Incidence of paediatric urolithiasis is increasing in Europe and North America. Nowadays the management of stone disease is a common practice in not endemic country.
- Trial name
- NCT04605315
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Neoplasms
A Study of JNJ-78306358 in Participants With Advanced Stage Solid Tumors
The purpose of this study is to determine the recommended phase 2 dose (RP2D) regimen(s) of JNJ-78306358 in Part 1 (Dose Escalation) and to determine the safety of JNJ-78306358 at the RP2D regimen(s) in Part 2 (Dose Expansion).
- Trial name
- NCT04991740
- Testing
- JNJ-78306358
- Where
- 5 sites in Israel, Spain
- Volunteers
- 39 people
- Sponsor
- Janssen Research & Development, LLC
Kidney Cancer
Gemcitabine With or Without Imatinib Mesylate in Treating Patients With Metastatic or Unresectable Kidney Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00323791
- Testing
- gemcitabine hydrochloride, imatinib mesylate, gene expression analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
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