Clinical trials: Kidney Calculi
Hyperoxaluria
A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk.
This pilot study is proposing a novel approach to directly target intestinal oxalate absorption with the drug Tenapanor, which was recently FDA-approved for treating hyperphosphatemia in patients with chronic kidney disease.
- Trial name
- NCT06481150
- Testing
- Tenapanor
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Overactive Bladder, Renal Colic
Preoperative Use of Darifenacin (Enablex) to Alleviate Postoperative Ureteral Stent Pain
This will be a randomized two arm prospective study to evaluate postoperative ureteral stent pain. One arm will be given 3 days of preoperative darifenacin and the control group will have the standard of care which is no…
- Conditions
- Overactive Bladder, Renal Colic, Pain, Postoperative
- Trial name
- NCT01189071
- Testing
- Darifenacin
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Nephrolithiasis
Narcotic-Free Percutaneous Nephrolithotomy
This is a randomized control trial comparing oral ketorolac and opioid medication for the use of post-operative analgesia.
- Trial name
- NCT05924165
- Testing
- 5mg Oxycodone, Q6 PRN, 10mg Ketorolac, Q6 PRN
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Nephrolithiasis
Pain Outcomes of Non-opioid vs. Opioid Analgesia for Kidney Stone Surgery.
There are two options for postoperative pain management: opioid and non-opioid analgesia. Pain outcomes will be compared in patients undergoing ureteroscopy and percutaneous nephrolithotomy by randomly administering opioid and…
- Trial name
- PO-NOA (NCT03584373)
- Testing
- Ketorolac Oral Tablet [Toradol], Acetaminophen, Oxycodone Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 119 people
- Sponsor
- Montefiore Medical Center
Kidney Stones
AR Projections for Eye-gaze Evaluation in Phantoms
This project aims to develop an augmented reality (AR) tool to enhance skill acquisition for endoscopic kidney stone surgery. Of the 100,000 patients who undergo an endoscopic kidney stone treatment annually in the United States…
- Trial name
- NCT07161024
- Testing
- Augmented reality
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Kidney Stone
Effect of Tamsulosin on Stone Expulsion and Pain Resolution in ED Patients With Ureterolithiasis
Tamsulosin (Flowmax)is approved by the FDA for the treatment for enlarged prostate. Several studies regarding the use of Tamsulosin for the treatment of lower kidney stones have been carried out in the non-Emergency Department…
- Trial name
- Flowmax (NCT00762424)
- Testing
- Flowmax
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- WellSpan Health
Nephrolithiasis
Intraoperative Cone-beam CT for Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a first-line treatment for kidney stones >2cm. Frequently, patients require multiple procedures to address their stone burden.
- Trial name
- NCT04556396
- Testing
- Cone beam CT
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Loyola University
Obesity
Obesity and Endogenous Oxalate Synthesis
The goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones.
- Trial name
- NCT03808090
- Testing
- Normal Individuals
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Urinary Lithiasis, Kidney Diseases
Toradol to Reduce Ureteroscopic Symptoms Trial
Double blinded randomized controlled clinical trial to assess the impact of intraoperative Toradol on post-operative pain scores for patients undergoing ureteroscopy for urinary stone management.
- Conditions
- Urinary Lithiasis, Kidney Diseases, Kidney Stone, Pain, Postoperative
- Trial name
- TRUST (NCT03111381)
- Testing
- Toradol
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Yale University
Urinary Stone
A Study to Assess the Effect of Cannabidiol Oil on Pain After Ureteroscopy for Kidney Stones
The purpose of this study is to determine if CBD oil has any effect on decreasing postoperative pain control following ureteroscopy for urinary stone disease, and to determine if CBD oil has any effect in decreasing the amount of…
- Trial name
- NCT04387617
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Kidney Calculi, Ureteral Calculi
Study of Ketorolac Versus Opioid for Pain After Endoscopy
A double blind randomized controlled trial designed to compare pain control and safety with ketorolac and oxycodone in the post-operative setting for patients undergoing ureteroscopy for treatment of urinary stones.
- Trial name
- SKOPE (NCT03888144)
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Kidney Calculi, Urologic Diseases
Tranexamic Acid to Improve Same-day Discharge Rates After Holmium Laser Enucleation of the Prostate (HoLEP)
This study is designed to assess if there is a significant difference in same day discharge rates after Holmium Laser Enucleation of the Prostate (HoLEP).
- Conditions
- Kidney Calculi, Urologic Diseases, Benign Prostatic Hypertrophy
- Trial name
- NCT05082142
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Northwestern University
Hyperoxaluria, Nephrolithiasis
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
The purpose of this study is to evaluate the effect of ALLN-177 to reduce urinary oxalate excretion in patients with recurring kidney stones and enteric or idiopathic hyperoxaluria.
- Trial name
- NCT02289755
- Testing
- ALLN-177
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Allena Pharmaceuticals
Ureteral Calculi, Kidney Stones
Study of Silodosin to Facilitate Passage of Urinary Stones
The purpose of this study is to assess if patients treated with silodosin will have a higher spontaneous passage rate of their ureteral stone than those treated with placebo.
- Conditions
- Ureteral Calculi, Kidney Stones, Urolithiasis
- Trial name
- NCT01144949
- Testing
- silodosin
- Where
- 27 sites in United States
- Volunteers
- 239 people
- Sponsor
- Watson Pharmaceuticals
Cystinuria
Lipoic Acid Supplement for Cystine Stone
This study evaluates how daily alpha lipoic acid supplementation affects cystine kidney stone recurrence. Half of the subjects will receive 1200 mg alpha lipoic acid orally daily for three years, while the other half will receive…
- Trial name
- ALA (NCT02910531)
- Testing
- Alpha lipoic acid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Chi, MD
Kidney Calculi
ShockPulse-SE vs. Trilogy Trial: Comparing the Performance of Two Intracorporeal Lithotripters for Removal of Large Renal Calculi
The purpose of this study is to measure how well two different devices work to break up and remove kidney stones. We are comparing a newer device to an older one to see which one is faster at breaking up kidney stones.
- Trial name
- NCT03959683
- Testing
- Trilogy Lithotrite, The ShockPulse-SE Lithotripsy System
- Where
- 4 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Indiana University
Secondary Hyperoxaluria, Nephrolithiasis
A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria
Identify individuals with greater absorption of oxalate based on increase in urinary oxalate excretion in response to a controlled oxalate-rich test meal.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Hyperoxaluria, Kidney Stones
- Trial name
- NCT03095885
- Testing
- Test Meal
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Allena Pharmaceuticals
Urinary Tract Stone
Moses vs. Thulium Laser Study
The incidence of urinary tract stone disease is increasing. According to the National Health and Nutrition Examination Survey, as of 2012, 10.6% of men and 7.1% of women in the United States are affected by renal stone disease.
- Trial name
- NCT04963062
- Testing
- Holmium laser with Moses lasers, Holmium laser with thulium lasers
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Wisconsin, Madison
Nephrolithiasis
Trial Assessing Renal Damage During Ureteroscopy
This is an ongoing randomized controlled trial of patients undergoing URSLL with unilateral non-obstructing renal stones. Patients are randomized to undergo URSLL with either the TFL or Ho:YAG laser.
- Trial name
- NCT05350423
- Testing
- Thulium Fibre Laser, Holmium:Yttrium-Aluminum-Garnet
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Icahn School of Medicine at Mount Sinai