Clinical trials: Kidney Calculi (or Renal Calculi / Nephrolithiasis), open to volunteers
Kidney Stone, Nephrolithiasis
Trial to Assess the Efficacy of EMPAgliflozin and Personalized Dietary Counseling for Kidney STONE Prevention
The aim of this randomized trial with a 2-by-2 factorial design is to test the efficacy of the SGLT2 inhibitor empagliflozin and personalized dietary counseling based on 24-hr urine collection results and dietary assessments for…
- Conditions
- Kidney Stone, Nephrolithiasis, Dietary Exposure
- Trial name
- EMPASTONE (NCT06653738)
- Testing
- Empagliflozin 10 MG, Personalized dietary counseling, Generic dietary counseling
- Where
- 21 sites in France, Germany and 2 more
- Volunteers
- 400 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Kidney Stones, Nephrolithiasis
DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones
Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- NCT07516535
- Testing
- Direct In-Scope Suction, Flexible and Navigable Suction Ureteric Access Sheath
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Kidney Stone, Infection
Novel Antimicrobial Solution to Prevent Infections
Ureteroscopy is the most common surgical treatment for kidney stones. Although rare, sepsis after ureteroscopy can be a life-threatening complication, occuring in <3% of patients.
- Conditions
- Kidney Stone, Infection, Infection Associated With Catheter, Sepsis
- Trial name
- NCT07881822
- Testing
- antimicrobial irrigation
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Kidney Calculi (or Renal Calculi / Nephrolithiasis), Supine Mini Percutaneous Nephrolithotomy
Supine vs. Prone Mini-PCNL in Children
Percutaneous nephrolithotomy (PCNL) is an established intervention for large or ESWL-resistant renal stones in pediatric populations.
- Conditions
- Kidney Calculi (or Renal Calculi / Nephrolithiasis), Supine Mini Percutaneous Nephrolithotomy, Prone Mini Percutaneous Nephrolithotomy
- Trial name
- SUPRO-PED (NCT07887945)
- Testing
- Group A, Group B
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Fayoum University Hospital
Kidney Stones, Nephrolithiasis
FANS vs CVAC for Medium to Large Stones
Improvements in ureteroscopes have led to improved stone free rates. Two new devices (FANS - Flexible and Navigable Suction) and the CVAC ureteroscope have never been compared head to head.
- Trial name
- NCT07514351
- Testing
- ureteroscopy, CVAC
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Ohio State University
Nephrolithiasis, Kidney Stone
Observational Approach Versus Surgical Intervention for Stones
The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to upfront surgery results in less healthcare-related life disruption due…
- Trial name
- OASIS (NCT07718802)
- Testing
- Surgery, Observation
- Where
- 4 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Children's Hospital of Philadelphia
Kidney Stone, Kidney Calculi
O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease
The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06330246
- Testing
- Low oxalate fixed diets pre-colonization, Moderately high oxalate fixed diets pre-colonization, Colonization with Oxalobacter formigenes
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stone, Kidney Calculi
Gut Oxalate Absorption in Calcium Oxalate Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased absorption of dietary oxalate, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06331546
- Testing
- Low-oxalate diet, High-oxalate diet, soluble oxalate gut absorption test
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Calculi, Nephrolithiasis
Comparison of Suction and Conventional Ureteral Access Sheaths in Kidney Stone Surgery
The goal of this observational study is to compare conventional and suction (aspiration) ureteral access sheaths used during retrograde intrarenal surgery (RIRS) in adults with kidney stones.
- Trial name
- NCT07866209
- Testing
- Conventional Ureteral Access Sheath, Suction Ureteral Access Sheath
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Antalya Health Sciences University
Kidney Stones, Nephrolithiasis
6.3Fr Versus 7.5Fr Mini-Flexible Ureteroscopy for Renal Stones (MINI-FURS)
This prospective, randomized, single-blinded, non-inferiority clinical trial will compare the clinical outcomes and cost-effectiveness of two mini-flexible ureteroscopes (6.3Fr and 7.5Fr) used during flexible ureteroscopy for the…
- Conditions
- Kidney Stones, Nephrolithiasis, Renal Calculi
- Trial name
- MINI-FURS (NCT07798336)
- Testing
- 6.3Fr Mini-Flexible Ureteroscope, 7.5Fr Mini-Flexible Ureteroscope
- Where
- Canada
- Volunteers
- 308 people
- Sponsor
- Sault Area Hospital
Kidney Stone, Urolithiasis, Calcium Oxalate
Heterozygous Individuals for AGXT and Kidney Stones
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production.
- Trial name
- NCT04430426
- Testing
- Controlled Diet
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Kidney Stones, Kidney Calculi
Endogenous Oxalate Synthesis in Idiopathic Calcium Oxalate Kidney Stone Disease
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate.
- Conditions
- Kidney Stones, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06989320
- Testing
- Low-oxalate diet and glycolate dosing, Oral glycolate dosing, Oral 13C- ascorbic acid dosing
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stones
CaOx Stone Prevention
This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones.
- Trial name
- NCT07225764
- Testing
- Chlorthalidone, Low oxalate diet
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Kidney Calculi, Nephrolithiasis
Nebulized Glubran 2-Assisted Tubeless PCNL Versus Conventional PCNL
This prospective randomized controlled study will compare two techniques used after percutaneous nephrolithotomy, a procedure for removing kidney stones.
- Trial name
- NCT07749807
- Testing
- Nebulized Glubran 2-Assisted Tubeless PCNL, Conventional PCNL With Nephrostomy Tube
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Kidney Stones, Urolithiasis
DISON I - Directly Integrated Suction and Optics System for the Treatment of Nephrolithiasis
A single-arm, multicenter, international, prospective interventional study designed to evaluate the safety and performance of an investigational device during retrograde intrarenal surgery for the treatment of renal calculi.
- Conditions
- Kidney Stones, Urolithiasis, Nephrolithiasis
- Trial name
- DISON I (NCT07712861)
- Testing
- RIRS with Investigational Device
- Where
- 5 sites in Argentina, Canada and 3 more
- Volunteers
- 75 people
- Sponsor
- Ventaris Surgical Incorporated
Urolithiasis, Stones, Kidney
Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration Technology
The goal of this clinical trial is to compare Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System and standard ureteroscopy (URS) with laser lithotripsy for the treatment of urolithiasis.
- Conditions
- Urolithiasis, Stones, Kidney, Renal Stones, Kidney Stones
- Trial name
- TRUST (NCT07101809)
- Testing
- Steerable Ureteroscopic Renal Evacuation (SURE) using the CVAC System, Standard Ureteroscopy (URS)
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Calyxo, Inc.
Kidney Stones, Nephrolithiasis
Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery
This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia.
- Trial name
- RIRS-VENT (NCT07705646)
- Testing
- Standard Ventilation, Hypoventilation, Intermittent Apnea Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Kidney Stones, Nephrolithiasis
Thulium Fiber Laser (TFL) vs Thulio Pulsed Thulium:YAG (p-Tm:YAG)
This research study is being conducted to assess the ability and efficiency of two laser systems to break up kidney stones during ureteroscopy with laser lithotripsy for kidney stone treatment.
- Trial name
- NCT06721975
- Testing
- Thulio pulsed Thulium:YAG (p-Tm:YAG), Thulium Laser Fiber (TFL)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Pediatric Urolithiasis, Kidney Stone
Standard Versus Flexible and Navigable Suction Ureteral Access Sheath in Pediatric Flexible Ureterorenoscopy for Renal Stones < 2 cm
This randomized controlled trial aims to compare the efficacy and safety of a Flexible and Navigable Suction Ureteral Access Sheath (FANS) versus a standard ureteral access sheath during flexible ureterorenoscopy (FURS) in…
- Conditions
- Pediatric Urolithiasis, Kidney Stone, Nephrolithiasis
- Trial name
- FANS-UAS (NCT07689565)
- Testing
- Standard Ureteral Access Sheath (Boston Scientific)., Flexible and Navigable Suction UAS (ClearPetra).
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Urolithiasis, Nephrolithiasis
Access Sheaths With Aspiration for Renal RetrOgrade Surgery, Randomized CompArative Outcomes
The goal of this clinical trial is to learn whether the ClearPetra ureteral access sheath (Coloplast) is more effective than the Navigator ureteral access sheath (Boston Scientific) in treating intrarenal kidney stones of 1-3 cm…
- Conditions
- Urolithiasis, Nephrolithiasis, Kidney Calculi, Ureteroscopy
- Trial name
- ARROCA01 (NCT07678255)
- Testing
- ClearPetra ureteral access sheath, Navigator ureteral access sheath
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío