Clinical trials: Kidney Disease, Chronic
Chronic Kidney Failure
Benazepril for Advanced Chronic Renal Insufficiency
The purpose of this study is to further determine whether benazepril, could safely slow the progression of renal dysfunction in non-diabetic patients with advanced renal insufficiency.
- Trial name
- NCT00270426
- Testing
- Benazepril
- Sponsor
- Southern Medical University, China
End-Stage Renal Disease (ESRD)
A Study of Avacopan in Participants With Normal Renal Function and Participants With End-Stage Renal Disease (ESRD)
The primary objective of the study is to evaluate the pharmacokinetics (PK) of avacopan and metabolite (M1) after a single dose of avacopan in participants with normal renal function and participants with ESRD requiring…
- Trial name
- NCT06468826
- Testing
- Avacopan
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Amgen
Kidney Failure, Chronic
The Effect of Intravenous Iron Therapy and Erythropoiesis-stimulation Agent Combination on Renal Transplant Outcomes
RBC transfusion (RBCT) after kidney transplantation(KT) is about 50%. Anemia is common after kidney transplant surgery due to intraoperative blood loss, delayed graft function, and side effects of immunosuppressive drugs.
- Trial name
- NCT05719376
- Testing
- Monofer (experimental), control group
- Where
- South Korea
- Volunteers
- 302 people
- Sponsor
- Yonsei University
Chronic Kidney Disease, End Stage Renal Failure on Dialysis
Safety and Efficacy Study of BCD-066 Compared to Aranesp® for Anemia Treatment in Chronic Kidney Disease Patients
The purpose of the study is to prove equivalence of efficacy and safety of BCD-066 and Aranesp® in treatment of anemia in end-stage chronic kidney disease patients on dialysis.
- Conditions
- Chronic Kidney Disease, End Stage Renal Failure on Dialysis, Anemia
- Trial name
- NCT02506868
- Testing
- Darbepoetin alfa
- Where
- 30 sites in Russia
- Volunteers
- 196 people
- Sponsor
- Biocad
Covid19, Environmental Exposure
Study on Kidney Disease and EnviromenTal Chemical
1. Purpose: To confirm the changes in lifestyle due to differences in perceptions of infectious disease risk after the COVID-19 pandemic, decrease in exposure levels of environmentally hazardous chemicals and changes in…
- Conditions
- Covid19, Environmental Exposure, Chronic Kidney Diseases
- Trial name
- NCT04679168
- Where
- South Korea
- Volunteers
- 310 people
- Sponsor
- Seoul National University Hospital
Chronic Kidney Disease on Hemodialysis, Thyroid Gland Disease
Interleukin-6 and Thyroid Dysfunction in Hemodialysis Patients
Chronic kidney disease (CKD) is often associated with multiorgan complications, including thyroid hormone dysfunction. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has been proposed as a marker of inflammation that may…
- Trial name
- NCT07328113
- Testing
- Thyroid hormone
- Where
- Indonesia
- Volunteers
- 65 people
- Sponsor
- Dr. Soetomo General Hospital
Type 1 Diabetes Mellitus (T1DM), End-Stage Renal Disease
Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden
The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease.
- Trial name
- NCT06883318
- Where
- Sweden
- Volunteers
- 115,000 people
- Sponsor
- Umeå University
Chronic Kidney Disease, Unspecified Complication of Kidney Transplant
SodiUm Burden Lowered by Lifestyle Intervention: Self-Management and E-health Technology
The purpose of this study is to evaluate the effects and efficacy of dietary sodium restriction by mean of a new healthcare approach in patients with chronic kidney disease.
- Trial name
- SUBLIME (NCT02132013)
- Testing
- Intervention SUBLIME
- Where
- 4 sites in Netherlands
- Volunteers
- 99 people
- Sponsor
- University Medical Center Groningen
Heart Transplantation
Exchange of Azathioprine by Mycophenolatmofetile and Cyclosporine A Dose Reduction After Heart Transplantation
The purpose of this study is to improve or save renal function by optimizing the immunosuppressive regimen by reducing the Cyclosporine A dose and the exchange of Azathioprine by Mycophenolatmofetile, which is an effective…
- Trial name
- NCT00359814
- Testing
- Mycophenolatmofetile, Cyclosporin A
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Hannover Medical School
Chronic Kidney Diseases, Inflammation
Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition
Patients with chronic kidney disease, who have evidence of systemic inflammation with increased cardiovascular risk, will be enrolled into this trial.
- Trial name
- RESCUE (NCT03926117)
- Testing
- Ziltivekimab
- Where
- 49 sites in United States
- Volunteers
- 264 people
- Sponsor
- Novo Nordisk A/S
Kidney Diseases, Hemodialysis Complication
Hemodialysis Adequacy Using a Heparin-grafted Dialyzer and a Citrate-enriched Dialysate
After providing informed consent, patients will be randomized to either the intervention treatment ("EvoCit procedure") or the control treatment ("EvoHep procedure").
- Conditions
- Kidney Diseases, Hemodialysis Complication, End Stage Renal Disease
- Trial name
- EvoCit-HD (NCT03887468)
- Testing
- EvoCit, EvoHep
- Where
- 2 sites in Belgium
- Volunteers
- 38 people
- Sponsor
- Universitair Ziekenhuis Brussel
End Stage Renal Disease, Hypoalbuminemia
Impact of Providing High Protein Bar to Dialysis Patients With Low Serum Albumin
This study is to evaluate the impact of providing high protein supplementation in the form of a medical food bar containing 20grams of protein eath to hypoalbuminemic dialysis patients.
- Conditions
- End Stage Renal Disease, Hypoalbuminemia, Malnutrition
- Trial name
- NCT00597025
- Testing
- Protein Food Bar Intelligent Indulgence
- Where
- 2 sites in United States
- Volunteers
- 375 people
- Sponsor
- Satellite Healthcare
Chronic Kidney Diseases, Cystic Kidney Disease
Contrast-enhanced Ultrasound for Complex Kidney Lesion Diagnosis in Patients With CKD Extension
The purpose of this research study is to evaluate contrast-enhanced ultrasound for kidney malignancies.
- Trial name
- CEUS-CKDx (NCT03196076)
- Testing
- Perflutren Lipid microsphere
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
End-Stage Renal Disease
Belatacept in Renal Transplantation With Intermediate Risk Maryland Aggregate Pathology Index (MAPI) Scores
This will be a pilot study to investigate the use of belatacept (BMS) therapy in kidney transplant patients who have a MAPI score of greater than or equal to 8.
- Trial name
- NCT01496417
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland
IgA Glomerulonephritis
Therapeutic Evaluation of Steroids in IgA Nephropathy Global Study (TESTING Low Dose Study)
This study will evaluate the long-term efficacy and safety of low dose oral methylprednisolone compared to matching placebo, on a background of routine RAS inhibitor therapy, in preventing kidney events in patients with IgA…
- Trial name
- TESTING (NCT01560052)
- Testing
- methylprednisolone
- Where
- 66 sites in Australia, Canada and 4 more
- Volunteers
- 503 people
- Sponsor
- The George Institute
Vitamin C, Oral Administration
Oral Vitamin C Administration on Erythropoietin Dosing Requirement in End-Stage Renal Disease Patients on Regular Hemodialysis
The study aimed to evaluate the safety and efficacy of oral vitamin C administration on erythropoietin dosing requirement in end-stage renal disease patients on regular hemodialysis.
- Conditions
- Vitamin C, Oral Administration, Erythropoietin, End-Stage Renal Disease
- Trial name
- NCT07076108
- Testing
- Normal regimen of treatment of anemia, Vitamin C
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
End-Stage Renal Disease
Peroral Supplemental Nutrition in End-stage Renal Disease With and Without HIV Comorbidity
End-stage renal disease is often accompanied by malnutrition due to less appetite, metabolic changes or both. Human immunodeficiency virus-infection may exacerbate the state of malnutrition.
- Trial name
- NCT00687050
- Testing
- peroral high-caloric supplemental nutrition, peroral supplemental nutrition
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Chronic Rejection, Kidney Insufficiency
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients
The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA after renal transplant.
- Trial name
- NCT00261547
- Testing
- Rituximab
- Sponsor
- Massachusetts General Hospital
ESRD
Assessment of Gonadal Functions in Uremic Male Patients
1. Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) . 2. Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin…
- Trial name
- NCT04710238
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Kidney Disease
Supplemented Very Low Protein Diet and the Progression of Chronic Kidney Disease
This is a prospective single center randomized controlled trial with a total duration of 18 months aiming to evaluate the effectiveness and the safety of a very low protein diet supplemented with ketoanalogues of essential…
- Trial name
- KETOPROG (NCT02031224)
- Testing
- Conventional low protein diet, Very low protein diet supplemented with Ketosteril
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Anemia Working Group Romania
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