Clinical trials: Kidney Disease, Chronic
COPD
Drug-drug Interaction Study of CHF5993 With Cimetidine
The purpose of this study is to evaluate the pharmacokinetic interaction when CHF5993 (pressurized metered-dose inhaler (pMDI) is administered with Cimetidine (probe inhibitor of the organic cation transport in the kidneys), by…
- Trial name
- NCT02287272
- Testing
- CHF 5993 pMDI, Cimetidine plus CHF5993 pMDI
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Metabolic Acidosis
Correction of Metabolic Acidosis in End Stage Renal Disease (ESRD)
The investigators want to evaluate whether an original action based on the administration of alkali (mainly sodium bicarbonate) is able to significantly modify renal death and to reduce mortality due to cardiovascular events.
- Trial name
- UBI (NCT01640119)
- Testing
- Bicarbonate
- Where
- 2 sites in Italy
- Volunteers
- 728 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Chronic Kidney Disease
Canadian Study of Prediction of Risk and Evolution to Dialysis, Death and Interim Cardiovascular Events Over Time
This study will follow 2500 prevalent Chronic Kidney Disease (CKD) patients with Glomerular Filtration Rate (GFR) from 15-45 ml/min for 30 months with serial measurements every 6 months and subsequent annual chart review up to 60…
- Trial name
- CanPREDDICT (NCT00826319)
- Where
- 25 sites in Canada
- Volunteers
- 2,602 people
- Sponsor
- University of British Columbia
Kidney Disease, Chronic, End Stage Kidney Disease
An Observational Study of Patients With Chronic Kidney Disease
TARGET-KIDNEY is an observational research study to conduct a comprehensive review of outcomes for patients with chronic kidney disease (CKD) and end-stage renal disease (ESKD).
- Trial name
- NCT05774392
- Testing
- Observational
- Sponsor
- Target PharmaSolutions, Inc.
Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease
This is a proposal for a retrospective observational study of the safety of metformin use in patients with chronic kidney disease, compared to other commonly used diabetes drugs.
- Trial name
- NCT03921242
- Testing
- Metformin, Sulfonylurea, DPP-4 inhibitor
- Where
- 2 sites in United States
- Volunteers
- 4,888 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Renal Failure
AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)
The purpose of this study is to see if rosuvastatin helps to reduce the number of heart attacks, strokes and cardiovascular deaths in patients undergoing haemodialysis.
- Trial name
- NCT00240331
- Testing
- 10mg Rosuvastatin
- Where
- 239 sites in Australia, Austria and 23 more
- Volunteers
- 2,776 people
- Sponsor
- AstraZeneca
Obesity, Morbid, End Stage Renal Disease
Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Kidney Transplant Candidates
The aim of this pilot prospective interventional study is to evaluate the efficacy of endoscopic sleeve gastroplasty (ESG) in allowing obese subjects (≥35 kg/m2) with end stage renal disease who need of kidney transplantation to…
- Conditions
- Obesity, Morbid, End Stage Renal Disease, Kidney Transplantation, Endoscopic Sleeve Gastroplasty
- Trial name
- ESGiTXKidney (NCT05917795)
- Testing
- Endoscopic Sleeve Gastroplasty (ESG)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
CKD, Renal Insufficiency Chronic
The CPH-MBD Cohort Dietary Substudy - Comparison of Methods for Dietary Registrations
The aim of the study is to assess the association between the calcium and phosphorus balance and the stage of kidney disease measured by creatinine clearence in patients with chronic kidney disease stage 4 and 5.
- Conditions
- CKD, Renal Insufficiency Chronic, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder, Pre-dialysis
- Trial name
- NCT07312981
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- University of Copenhagen
Kidney Failure, Chronic
Oral Anticoagulation in Haemodialysis Patients
Guidelines recommend oral anticoagulation with vitamin K antagonists for atrial fibrillation whenever the CHADS2VASC score is superior or equal to 2.
- Trial name
- AVKDIAL (NCT02886962)
- Testing
- No oral anticoagulation, Oral anticoagulation with vitamin K antagonists
- Where
- 25 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Chronic Kidney Diseases
everlinQ Endovascular Access Systems Enhancements (EASE-2) Study
Prospective, single-center study to evaluate the everlinQ endoAVF System when used to create an endoAVF in hemodialysis patients.
- Trial name
- NCT03708562
- Testing
- everlinQ endoAVF System
- Where
- Paraguay
- Volunteers
- 24 people
- Sponsor
- C. R. Bard
Chronic Kidney Disease, Cardiovascular Disease
Methylation Biosignature in Childhood Chronic Kidney Disease
Chronic kidney disease (CKD) and end-stage renal disease are highly prevalent in Taiwan. Cardiovascular disease (CVD) is the most common cause of death in children with CKD. Nitric oxide (NO) deficiency links CKD and CVD.
- Trial name
- childhoodCKD (NCT02022046)
- Testing
- Methylation biosignature
- Where
- Taiwan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Secondary Hyperparathyroidism Due to Renal Causes, Chronic Kidney Diseases
Safety, Efficacy, PK and PD of CTAP101 (Calcifediol) ER Capsules for SHPT in HD Patients VDI
Safety, Efficacy, PK and PD of CTAP101 (calcifediol) ER Capsules for SHPT in HD Patients VDI
- Conditions
- Secondary Hyperparathyroidism Due to Renal Causes, Chronic Kidney Diseases, Vitamin D Deficiency, Stage 5 Chronic Kidney Disease
- Trial name
- NCT03602261
- Testing
- Calcifediol Oral Capsule
- Where
- 18 sites in United States
- Volunteers
- 44 people
- Sponsor
- OPKO Health, Inc.
End Stage Renal Disease
Generic Tacrolimus in the Elderly - Prograf® vs Tacni®
Test bioequivalence of generic tacrolimus (Tacni), using original tacrolimus (Prograf) as comparator, in elderly (>60 yr) renal transplant recipients
- Trial name
- GenTac (NCT01698541)
- Testing
- Tacrolimus
- Where
- Norway
- Volunteers
- 28 people
- Sponsor
- University of Oslo School of Pharmacy
Kidney Transplantation, Kidney Failure, Chronic
Study of Subclinical Viral Infection
Chronic allograft injury is the leading cause of graft loss in renal transplantation. The shortage of available kidneys for transplantation has reached crisis levels with increasing numbers of waiting list mortalities.
- Trial name
- NCT01615341
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Seattle Children's Hospital
Kidney Failure, Chronic
Efficacy and Safety of Lanthanum in Controlling Serum Phosphate Levels in Subjects With End Stage Renal Disease Who Require Treatment for High Levels of Phosphate in Their Blood
The purpose of this study is to test how well higher doses of lanthanum carbonate reduce the pre-dialysis level of serum phosphorus in subjects undergoing dialysis due to end stage renal disease.
- Trial name
- NCT00150566
- Testing
- Lanthanum carbonate
- Volunteers
- 460 people
- Sponsor
- Shire
Chronic Kidney Diseases, Diabetes Mellitus
Inflammation and Stem Cells in Diabetic and Chronic Kidney Disease
The proposed studies will examine the effect of fisetin on adipose tissue-derived mesenchymal stem/stromal cell function, kidney function, markers of inflammation, and physical function in individuals with advanced chronic kidney…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Diabetic Nephropathies
- Trial name
- NCT03325322
- Testing
- Fisetin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Chronic Kidney Diseases
A Pilot Study of The CKM JumpStart Tool
This is a randomized pilot study to test the feasibility and acceptability of a tool to promote discussion about conservative kidney management (CKM) among older patients with advanced CKD and their providers.
- Trial name
- NCT05753020
- Testing
- CKM Jumpstart Tool
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Washington
Obesity, ESRD
Bariatric Surgery for ESRD Patients vs Control
This study will address a true clinical problem by developing a risk/benefit analysis for rapid surgical weight loss in the ESRD population.
- Trial name
- NCT00580762
- Testing
- Roux-en-y gastric bypass (RYGB)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in Indian People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Practice
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access.
- Trial name
- IN-REALITY (NCT06763146)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- India
- Volunteers
- 1,200 people
- Sponsor
- Bayer
Chronic Kidney Diseases, Cardiovascular Diseases
Treating Metabolic Acidosis in Chronic Kidney Disease to Prevent Adverse Kidney and Cardiovascular Outcomes
Upon completion, this project will determine if treatment of metabolic acidosis in non-diabetic study participants with reduced kidney function (chronic kidney disease [CKD] stage 3) associated with high blood pressure…
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- NCT06545461
- Testing
- Fruits and Vegetables (F+V), Sodium Bicarbonate (NaHCO3), Usual Care
- Volunteers
- 108 people
- Sponsor
- Donald Wesson
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