Clinical trials: Kidney Disease, Chronic
End Stage Renal Disease
ENhancing Maturation of Autogenous Arteriovenous Hemodialysis Access by Aggressive surveillaNCe With Duplex and Endovascular Treatment
The aim of this study is to evaluate whether Aggressive duplex surveillance after vascular access surgery with native vein for hemodialysis can increase the maturation rate of arteriovenous fistula.
- Trial name
- ENHANCE (NCT01597115)
- Testing
- Duplex ultrasonography
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Healthy, Myocardial Fibrosis
Molecular MRI of the Fibrotic Heart
This study is a feasibility study to validate magnetizatin transfer (MT)-weighted balanced steady state free precession (bSSFP) cine cardiac magnetic resonance (CMR) against current clinical gold standard diagnostics, and to…
- Conditions
- Healthy, Myocardial Fibrosis, Chronic Kidney Disease
- Trial name
- NCT02012725
- Testing
- Arm 1 MRI with gadolinium
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Moriel Vandsburger
Brachiobasilic Arteriovenous Fistula
Trial Comparing One-stage With Two-stage Basilic Vein Transposition
Arteriovenous fistulas (AVFs) are made by joining a vein to an artery in order to get the vein dilated with sufficient blood flow in order to puncture the vein and clear the blood from wastes, in patients whose kidneys are…
- Trial name
- NCT01274117
- Testing
- Transposition of the basilic vein and anastomosis with the brachial vein
- Where
- Greece
- Volunteers
- 16 people
- Sponsor
- University of Patras
End-stage Renal Disease
Study the Effect of Niacin on Lipoprotein (a) Concentration and Hyperphosphatemia in Hemodialysis Patients
The goal of this clinical trial is to learn if Niacin has an effect on lipoprotein (a) concentration and hyperphosphatemia, which represent strong risk factors for cardiovascular diseases, in End-stage renal disease (ESRD)…
- Trial name
- NCT06406140
- Testing
- Niacin tablets 500 mg
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Chronic Kidney Disease, Cardiovascular Diseases
Cardiovascular Disease in Patients With Chronic Kidney Disease: Polish Kidney- Heart Project
This is an observational longitudinal study which will collect routine demographic, laboratory and clinical parameters of patients with chronic kidney disease (CKD) in the Silesian and Warmia and Mazury Regions (Poland) aimed at…
- Trial name
- NCT06083168
- Where
- 2 sites in Poland
- Volunteers
- 6,000 people
- Sponsor
- Medical University of Silesia
Coronary Artery Disease, Diabetes Mellitus
Impact of Chronic Kidney Disease on the Effects of Ticagrelor in Patients With Diabetes and Coronary Artery Disease
Patients with diabetes mellitus (DM) are at increased risk of atherothrombotic events. Importantly, DM is a key risk factor for the development of chronic kidney disease (CKD), which further enhances atherothrombotic risk.
- Trial name
- NCT02539160
- Testing
- ticagrelor
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Florida
ESRD, Cardiovascular Diseases
The Impact of Statin Holiday in Dialysis Patients Over 70 Years Old on Mental Function, Physical Function and Frailty
Patients who are on chronic dialysis and 70 and older are frequently on multiple medications including statins. However, the benefit of statins in dialysis patient population is uncertain.
- Trial name
- NCT03663049
- Testing
- discontinue statin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Loyola University
Chronic Kidney Disease Requiring Chronic Dialysis, Hyperphosphatemia
Low-Phosphate Diet and Fibroblast Growth Factor-23 Level
The aims of the study are to evaluate the effect of low-phosphate diet on FGF23 level and to determine the optimal amount of dietary phosphate restriction in hemodialysis patients.
- Conditions
- Chronic Kidney Disease Requiring Chronic Dialysis, Hyperphosphatemia, Dietary Intervention, Elevated Fibroblast Growth Factor-23
- Trial name
- NCT03367338
- Testing
- Low-phosphate diet
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Wan-Chuan Tsai
Chronic Kidney Disease Stage 4 and 5, Exercise
The Effect of Home-Based Exercise on Chronic Kidney Disease Patients
The aim of this study is to investigate the effects of home-based exercise on the risk of sarcopenia, functional capacity, anxiety, depression, fatigue, sleep, and quality of life in patients aged 45 and over with chronic kidney…
- Conditions
- Chronic Kidney Disease Stage 4 and 5, Exercise, Home Based Care, Sarcopenia
- Trial name
- NCT07371858
- Testing
- Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Akdeniz University
Lung Transplant; Complications
Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients
Lung transplantation is a life-saving option in patients with end-stage lung disease. The introduction of calcineurin inhibitors has significantly improved long-term outcome in lung transplantation.
- Trial name
- REVOLUTION (NCT05001074)
- Testing
- Extended release tacrolimus, Immediate release tacrolimus
- Where
- Netherlands
- Volunteers
- 145 people
- Sponsor
- Heleen Grootjans
Chronic Kidney Disease
A Research Proposal to Set up an Integrated National Data Bank and Monitoring System and to Establish the Indicators and Risk Factors for Chronic Kidney Disease
This project expects the integrated database of terminally renal ill patients combines clinical and files of Health Insurance and renal medical society database.
- Trial name
- NCT01452360
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Colorectal Cancer (CRC)
Spatial RadiomIcs and TRanscriptomics to the DIscovery of the Cross-link Between Colon Cancer and ChrOnic Kidney Disease
The incidence of colorectal cancer (CRC) is higher in patients with chronic kidney disease (CKD) compared to general population. Causal factors have not been clarified so far, although some hypothesis could be formulated.
- Trial name
- SIRIO (NCT06886282)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute, Naples
Chronic Kidney Diseases, Diabetes Mellitus
Prevalence of Chronic Kidney Disease (CKD) and Risk Factors in Sub-Saharan Africa
Prospective cross-sectional study at the outpatient clinic (OPC) of the Bagamoyo District Hospital (BDH) in Tanzania. Assessment of basic epidemiological data (Point prevalence and risk factors) on CKD with simple clinical…
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Hypertension, Tuberculosis
- Trial name
- RenalOne (NCT03458338)
- Testing
- estimated glomerular filtration rate and albuminuria
- Where
- Switzerland
- Volunteers
- 1,006 people
- Sponsor
- University Hospital, Basel, Switzerland
Renal Failure, End Stage
The ONE Study ATDC Trial
To collect evidence of the safety of administering autologous tolerogenic dendritic cells (ATDC) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed…
- Trial name
- ONEatDC (NCT02252055)
- Testing
- ATDC_Nantes
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
Acute Kidney Injury, Arterial Hypertension
Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients
To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
- Conditions
- Acute Kidney Injury, Arterial Hypertension, Obesity, Cardio Vascular Disease
- Trial name
- NCT02499185
- Testing
- Nephro Check Test, serum creatinine measurement
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Vitamin D Deficiency, Vascular Calcification
Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis
Aim: To investigate whether cholecalciferol (4800 U/daily) or placebo for 16 weeks reduces proteins levels associated with vascular calcification (osteoprotegerin, osteopontin, osteocalcin) in patients treated with peritoneal…
- Conditions
- Vitamin D Deficiency, Vascular Calcification, Renal Insufficiency, End Stage Renal Failure on Dialysis
- Trial name
- NCT02598635
- Testing
- Cholecalciferol
- Where
- Mexico
- Volunteers
- 58 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Renal Impairment
Pharmacokinetics, Safety and Tolerability of AGO178C in Subjects With Renal Deficiencies Compared With Healthy Subjects
This study will assess the pharmacokinetics, safety and tolerability of a single dose of AGO178C in subjects with mild, moderate, severe renal impairment and end-stage renal disease with that in healthy matched control subjects.
- Trial name
- NCT01459250
- Testing
- AGO178C
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Renal Failure Chronic, Transplant;Failure,Kidney
Continuous Spinal Anesthesia in Renal Transplantation
Renal transplantation is now recognized as a treatment of choice for patients with end-stage renal disease. An adequate anesthetic technique should achieve hemodynamic stability and enhance perfusion of the transplanted kidney.
- Conditions
- Renal Failure Chronic, Transplant;Failure,Kidney, Anesthesia
- Trial name
- NCT03436368
- Testing
- Continuous spinal anesthesia, General anesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Nazmy Edward Seif
Chronic Kidney Disease
Expanding and Promoting Alternative Care and kNowledge in Decision-making Trial
The goal of this clinical trial is to compare two health system-based approaches for offering kidney failure treatment options to older patients with kidney failure, specifically, to ensure patients are actively involved in a…
- Trial name
- ExPAND (NCT06243068)
- Testing
- Educate and Engage, Educate and Engage Plus Kidney Supportive Care Program
- Where
- 25 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- George Washington University
Diabetes, Renal Failure , Chronic
Implementation Trial In patieNts With rEnal failuRe and diAbetes for Major Adverse reNal and Cardiovascular Events
The goal of this clinical study is to establish if the use of public health-related messages, designed and disseminated to a targeted population, will result in tangible improvements in patient outcomes and healthcare practices.
- Trial name
- ITINERANCE (NCT07634718)
- Testing
- Health-related messages
- Where
- France
- Volunteers
- 125,000 people
- Sponsor
- Nantes University Hospital
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