Clinical trials: Kidney Disease, Chronic
Chronic Kidney Disease Stage 4
The Agenda-Setting for Kidney Disease Open Pilot Trial
The goal of this open pilot is to practice using an intervention and surveys before a larger pilot stepped wedge clinical trial.
- Trial name
- ASK (NCT07221604)
- Testing
- Chronic Kidney Disease Structured Agenda-Setting Tool
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
End Stage Renal Disease
Evaluation of Contact Phase Activation During Hemodialysis
Every patient included in the study will undergo 3 standardised hemodialysis treatments, each using a different dialysis membrane (PMMA, PS, AN69ST). The order of the membranes used will be randomized.
- Trial name
- c-phact (NCT03090984)
- Testing
- PMMA (BKU), PS (Phylter), AN69ST (Evodial)
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Kidney Diseases, Renal Failure
Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)
Phase 2 basket trial including 2 open-label single-arm cohorts: REPAIR CKD cohort and REPAIR Dialysis cohort. Open label colchicine 0.3 mg daily for 8 weeks followed, in patients who tolerated the 0.3 mg dose, by forced titration…
- Trial name
- NCT06203977
- Testing
- Colchicine
- Where
- 3 sites in Canada
- Volunteers
- 96 people
- Sponsor
- Hamilton Health Sciences Corporation
Chronic Kidney Disease
Niacin and Endothelial Function in Early CKD
The purpose of this study is to obtain information on whether raising levels of HDL-cholesterol (the "good" cholesterol) can improve how blood vessels work in kidney disease.
- Trial name
- NCT00852969
- Testing
- Niacin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Decompensated Heart Failure
Impact of Therapy Optimization on the Level of Biomarkers in Patients With Decompensated Heart Failure
In this pilot, investigator-initiated multi-centre, multinational, observational study the investigators would like to examine the impact of therapy optimization on the level of biomarkers in patients with acute decompensated and…
- Trial name
- MOLITOR (NCT01501981)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
ESRD
Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD
Non diabetic patients on renal replacement therapy are prone to changes in body composition with an increase in visceral fat and muscle wasting all favoured by the insulin resistant state.
- Trial name
- NCT01253928
- Testing
- Pioglitazone
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Injury, Multi Organ Failure
Long Term Renal Function After CRRT in the Paediatric Intensive Care Unit, a Follow-up Study.
In this study the investigators will evaluate the long-term renal function in children treated with continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) and multiple organ failure (MOF) in the pediatric…
- Conditions
- Acute Kidney Injury, Multi Organ Failure, Children, Only
- Trial name
- NCT05629273
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Region Stockholm
Chronic Kidney Disease, Stage 4 (Severe), Chronic Kidney Disease, Stage 5
Impact of PREMs in the Shared Decision Process for Renal Replacement Treatment Methods.
The French "my health 2022" plan is the first bundled payment initiative for stage 4 and 5 chronic kidney disease (CKD) pathway with the aim to improve the quality of care and promote a multi professional collaboration for a more…
- Trial name
- PEACE (NCT06819345)
- Testing
- Survey form
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Cirrhosis, Food Preferences
Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation
This study evaluates the influence of the taste sensitivity, of food preferences and of the reward system on the energetic balance before and after liver transplantation in cirrhotic patients and after kidney transplantation in…
- Conditions
- Cirrhosis, Food Preferences, Taste Disorders, Protein-Energy Malnutrition
- Trial name
- GREFFE (NCT02931812)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Kidney Failure, Chronic, Disorder of Vitamin D
Value Antiproteinuric Effects From Vitamin D Derivatives in Patient With Chronic Kidney Illness and the Lack of Vitamin D
The purpose of this study is to determine the value the additional antiproteinuric effects of vitamin D derivatives treatment, in patients with Chronic Kidney Illness phase II-IV, with lack of vitamin D and residual proteinuria…
- Trial name
- NEFROVID2010 (NCT01442272)
- Testing
- Hidroferol®, Paricalcitol: Zemplar®, Habitual medication
- Where
- 2 sites in Spain
- Volunteers
- 174 people
- Sponsor
- Hospital Universitario de Canarias
End Stage Renal Disease
Fluid Management Guided by Bioimpedance Analysis in Peritoneal Dialysis(PD) Patients.
1. Purpose: to investigate the effect of bioimpedance analysis(BIA) guided fluid management versus experiential way on clinical outcome in peritoneal dialysis patients. 2.
- Trial name
- NCT02000128
- Testing
- bioimpedance monitoring, clinical monitoring
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sun Yat-sen University
End-Stage Renal Disease, Chronic Kidney Diseases
Technology-enabled Social Network Intervention to Increase Live Donor Kidney Transplantation
The study is a 2-arm randomized controlled trial among patients referred for kidney transplant evaluation at a single transplant center to compare the effects of a digital-analog intervention to increase living-donor kidney…
- Conditions
- End-Stage Renal Disease, Chronic Kidney Diseases, Kidney Transplant, Living Kidney Donor
- Trial name
- KT-CONNECT (NCT07072767)
- Testing
- Digital education outreach intervention for kidney transplant access and human guide, Digital education outreach intervention for kidney transplant access only (unguided)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- State University of New York at Buffalo
Renal Failure
Impact of Low Protein Diet Supplemented With Ketoanalogues Supplementation on Uremic Toxins Production
Chronic kidney disease (CKD) is associated with accumulation of uremic toxins like p-cresyl sulfate and indoxyl sulfate that are associated of cardiovascular complication and perturbation of glucose metabolism.
- Trial name
- KETO-GUT (NCT03959228)
- Testing
- keto-analogs
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Diseases
Accuracy of Glomerular Filtration Rate (GFR) Estimation Using Creatinine and Cystatin C and Albuminuria
The eGFR-C study will assess the accuracy of current and alternative tests of kidney function against a reference test in people with moderate (stage 3) chronic kidney disease (CKD).
- Trial name
- eGFR-C (NCT02433002)
- Where
- 6 sites in United Kingdom
- Volunteers
- 1,249 people
- Sponsor
- University of Birmingham
Chronic Kidney Disease
The BASE Study: Bicarbonate Administration to Stabilize Estimated Glomerular Filtration Rate (eGFR)
The two doses of sodium bicarbonate being tested are 0.5 and 0.8 mEq/kg-lean body weight (LBW) per day. Sodium bicarbonate, also known as baking soda, may help prevent kidney failure in people with chronic kidney disease.
- Trial name
- BASE (NCT02521181)
- Testing
- Lower Dose Sodium Bicarbonate, Higher Dose Sodium Bicarbonate
- Where
- 7 sites in United States
- Volunteers
- 194 people
- Sponsor
- Jennifer Gassman, PhD
Cardiovascular Diseases, Chronic Kidney Disease
Evaluating the Effect of Standard-of-care Erythropoiesis-stimulating Agents on Forearm Blood Flow in Nondialysis-dependent Subjects With Anaemia Associated With Chronic Kidney Disease.
In people diagnosed with chronic kidney disease (CKD) anaemia is a common problem and is often treated with EPO (Erythropoietin). One form of EPO used is Darbepoetin (Aranesp®).
- Trial name
- OPERA-CKD (NCT02987465)
- Testing
- Darbepoetin Alfa, Acetylcholine, Noradrenaline
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hypertension, Diabetes Mellitus, Type 2
ENCOMPASS: Expansion Study C
Some patients living with multiple long-term health conditions have difficulty accessing the services they need, despite available primary care and community resources.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Chronic Kidney Diseases, Ischemic Heart Disease
- Trial name
- NCT04791267
- Testing
- Community Health Navigator Program
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Calgary
Chronic Kidney Disease, Coronary Artery Disease
Feasibility and Pilot Testing of "My Heart and CKD" Online Shared Decision Aid
Many people with kidney disease also have heart disease. The procedures used to diagnose and treat heart disease (e.g., angiograms, angioplasty, or surgery) can improve symptoms and cardiovascular outcomes, but pose greater risks…
- Trial name
- MyHeart&CKD (NCT06920927)
- Testing
- Decision aid
- Where
- 2 sites in Canada
- Volunteers
- 220 people
- Sponsor
- University of Calgary
Obstructive Sleep Apnea, End Stage Renal Disease
Prognostic Impact of Sleep Apnea on Cardiovascular Morbidity and Mortality, in End Stage Renal Disease Patients
The purpose of this study is to prospectively evaluate the impact of sleep apnea on the cardiovascular morbidity and mortality of patients with end-stage renal disease.
- Trial name
- SASinHD_003 (NCT02073305)
- Testing
- No Sleep Apnea, Sleep Apnea - untreated, Sleep Apnea - treated
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiovascular Disease, Chronic Kidney Disease
Vascular Risk After Kidney Transplantation
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease progression after kidney transplant.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease, Diabetes, Vitamin D Deficiency
- Trial name
- NCT00374595
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- University of Nebraska
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