Clinical trials: Kidney Donor
Kidney Transplant
Effects Of Propofol And Sevoflurane On Plasma Mirna Levels İn Living Kidney Donors
Surgical interventions and associated tissue trauma induce a complex systemic inflammatory stress response characterized by the activation of neuroendocrine, metabolic, and immunological systems.
- Trial name
- NCT07760402
- Testing
- Sevoflurane, propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Living Donor of Kidney
Assessment of Differential Renal Function by CT in Living Donors
The purpose of this study is to assess the degree of agreement of the measurement of differential renal function in living donors by CT (computed tomography) and SPECT (single photon emission computed tomography).
- Trial name
- DOVISCAN (NCT02820376)
- Testing
- Differential renal function assessment by 4D CT
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Renal Injury
Different Vascular and Renal Parameters in Living Kidney Donors
Chronic kidney disease (CKD) has a high prevalence globally and is a global health concern. CKD is associated with increased risks of cardiovascular morbidity, mortality and therefore decreased quality of life in any stage of the…
- Trial name
- NCT06056466
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Addison Disease, Hypoaldosteronism
Adrenal Function After Living Kidney Donation
The success of kidney transplantation is hampered by the shortage of organs. One attractive strategy is the use of kidneys from living donors.
- Trial name
- NCT00251836
- Testing
- Laparoscopic hand-assisted donor nephrectomy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Chronic Liver Disease
Evaluation of Liver Fibrosis Staging With Acoustic Radiation Force Impulse Elastography
This is a prospective cohort Study for evaluation of liver fibrosis staging with acoustic radiation force impulse elastography in patients with chronic liver disease and healthy liver/kidney donors.
- Trial name
- NCT01283230
- Testing
- Acoustic radiation force impulse imaging
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Yonsei University
HHV8, HHV8 Infection
HHV8 and Solid Organ Transplantation
Solid organ transplant candidates will undergo serological screening for HHV8 at time of listing and transplantation. In the event of a recipient/donor mismatch R-/D+ or in the presence of a seropositive recipient (R+), blood…
- Conditions
- HHV8, HHV8 Infection, HHV8-Related Malignant Neoplasm, Kaposi Sarcoma
- Trial name
- NCT05081141
- Testing
- Diagnostic test for HHV8 exposure
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Cancer
Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant
RATIONALE: Giving donor natural killer cells to patients who have undergone donor bone marrow transplant may make the transplant work better and keep cancer cells from coming back.
- Trial name
- NCT00569283
- Testing
- therapeutic allogeneic lymphocytes
- Where
- 2 sites in South Korea
- Volunteers
- 18 people
- Sponsor
- Asan Medical Center
Kidney Transplant Donor
Modifiable Factors Affecting Racial Disparities in Kidney Donation
While many people offer to be evaluated at transplant centers as potential living donors to donate one kidney to someone they know, few ultimately donate. Racial/ethnic minorities are less likely to become living donors.
- Trial name
- NCT07793877
- Testing
- Not applicable- observational study
- Volunteers
- 2,332 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Endstage Kidney Disease
Implementing "Explore Transplant"- A Pilot Study
Patients with End Stage Kidney Disease (ESKD) require Renal Replacement Therapy (RRT) in order to survive, be it dialysis or kidney transplantation (KT).
- Trial name
- NCT03046732
- Testing
- Implementing "Explore Transplant" Education
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant, End Stage Kidney Disease (ESRD)
ABO- or HLA- Incompatible LDKT Compared to Waitlist/DDKT in Elderly Patients
This retrospective multicenter cohort study evaluates the survival outcomes of elderly patients (aged ≥60 years) with end-stage kidney disease who underwent ABO- or HLA-incompatible living donor kidney transplantation compared…
- Trial name
- NCT07436338
- Where
- 2 sites in South Korea
- Volunteers
- 1,819 people
- Sponsor
- Seoul National University Hospital
Kidney Transplant Recipients
Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplantation
The study will compare how well transplanted kidneys work and the response of people's immune systems as tacrolimus, a calcineurin inhibitor (CNI), is withdrawn.
- Trial name
- NCT01517984
- Testing
- Tacrolimus (CNI) Withdrawal, Standard Immunosuppressive Therapy
- Where
- 11 sites in United States, Canada
- Volunteers
- 52 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Laparoscopic Donor Nephrectomy, Perioperative Pain Management
Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor
This study aims to compare the effectiveness of spinal anesthesia adjuvant and quadratus lumborum block on the opioid requirement and perioperative pain on patients undergoing laparoscopic kidney transplant donor.
- Trial name
- NCT06764667
- Testing
- Spinal anesthesia adjuvant, Quadratus Lumborum Block (QLB), General Anesthesia
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
Kidney Transplant
Impact of Anti-HLA Donor-specific Antibodies in ABO-incompatible Kidney Transplantation
It was previously suggested an improvement of graft survival in ABO/HLA incompatible kidney transplantation (KT) compared with HLA (human leukocyte antigen) incompatible transplantation.
- Trial name
- A3 (NCT03423901)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Toulouse
Chronic Kidney Disease, End-stage Renal Disease
A Randomized Trial to Reduce the Disparity in Live Donor Kidney Transplantation
The main purpose of this study is to learn which educational method is most helpful to patients and their family members when they consider whether to pursue live donor kidney transplantation.
- Trial name
- NCT00785265
- Testing
- Group-Based (GB) Intervention, Home-Based (HB) Intervention
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
Renal Failure, End Stage
The ONE Study ATDC Trial
To collect evidence of the safety of administering autologous tolerogenic dendritic cells (ATDC) preparations to living-donor renal transplant recipients in the context of an international European Union funded consortium aimed…
- Trial name
- ONEatDC (NCT02252055)
- Testing
- ATDC_Nantes
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Nantes University Hospital
End-stage Renal Failure, Kidney Graft Rejection
Reference Group Trial for The ONE Study
To investigate the progression of the immunological response in living-donor kidney transplant recipients treated with a standard immunosuppressive regimen.
- Trial name
- NCT01656135
- Testing
- Blood drawing for immune monitoring and questionnaires
- Where
- 8 sites in United States, France and 3 more
- Volunteers
- 70 people
- Sponsor
- University of Regensburg
Kidney Failure
Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
An open-label study to assess the safety, efficacy, and tolerance of FCRx cell therapy in adult recipients within 12 months after kidney transplantation from a living donor.
- Trial name
- NCT00497926
- Testing
- Enriched Hematopoietic Stem Cell Infusion
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Talaris Therapeutics Inc.
Kidney Transplantation, Anxiety
The Effects of Pre-operative Anxiety on Anesthetic Recovery and Post-operative Pain in Donor Nephrectomy
Kidney transplant is the most effective choice of treatment for patients with end-stage kidney failure in terms of quality of life and longevity. Today, 20-25% of kidney transplantations are implemented with living donors.
- Conditions
- Kidney Transplantation, Anxiety, Pain, Acute, Anesthesia Recovery Period
- Trial name
- NCT03131258
- Testing
- Donor Nephrectomy
- Volunteers
- 48 people
- Sponsor
- Ege University
Renal Insufficiency
Atorvastatin in the Recipient's Kidney Graft From a Living Donor
Renal insufficiency is a priority disease in the health system, which may require renal replacement therapy based on kidney transplantation, which is considered as therapy of choice.
- Trial name
- ATORV15 (NCT02522117)
- Testing
- Atorvastatin
- Where
- Mexico
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Pain, Postoperative
Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy
The investigators will assess how the use of toradol and pregabalin affects return to bowel function and see if there is a difference in length of hospital stay.
- Trial name
- NCT03669081
- Testing
- Ketorolac, Pregabalin, Saline
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah