Clinical trials: Kidney Donors
Kidney Transplant Immunosuppression
Use of DNA Testing to Help Transition Kidney Transplant Recipients to Belatacept-only Immunosuppression
The purpose of the study is to identify kidney transplant patients that can be transitioned from multi-drug immunosuppression therapy to Belatacept monotherapy, using cell free DNA and gene expression as markers of immune…
- Trial name
- NCT04786067
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Texas Southwestern Medical Center
End-Stage Renal Disease, Chronic Kidney Diseases
Technology-enabled Social Network Intervention to Increase Live Donor Kidney Transplantation
The study is a 2-arm randomized controlled trial among patients referred for kidney transplant evaluation at a single transplant center to compare the effects of a digital-analog intervention to increase living-donor kidney…
- Conditions
- End-Stage Renal Disease, Chronic Kidney Diseases, Kidney Transplant, Living Kidney Donor
- Trial name
- KT-CONNECT (NCT07072767)
- Testing
- Digital education outreach intervention for kidney transplant access and human guide, Digital education outreach intervention for kidney transplant access only (unguided)
- Where
- United States
- Volunteers
- 550 people
- Sponsor
- State University of New York at Buffalo
Kidney Failure, Kidney Diseases
Expanding Live Donor Kidney Transplantation Through Advocacy Training and Social Media
This pilot study will be a clinical trial to test the feasibility and effectiveness of an educational intervention and a mobile health intervention in adults with end stage renal disease (ESRD) who have not yet identified a…
- Trial name
- ENGAGE (NCT03099434)
- Testing
- Facebook App, Live Donor Champion + Facebook App
- Where
- 2 sites in United States
- Volunteers
- 775 people
- Sponsor
- Johns Hopkins University
Transplantation, Kidney, Living Donors
Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients
The aim of this study is to determine a comprehensive immune profile of transplant donors and recipients through assessment of immune cell compositions in bone marrow, and lymph nodes.
- Conditions
- Transplantation, Kidney, Living Donors, Kidney Transplant Recipients
- Trial name
- NCT01150487
- Testing
- bone marrow aspirations, lymph node collection
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Mayo Clinic
Kidney Transplant Candidates
Increasing Communication About Live Donor Kidney Transplant
This study will test the efficacy of a communication intervention intended to increase and improve kidney transplant candidates' communication about live donor kidney transplantation.
- Trial name
- NCT01855438
- Testing
- Living Donor Transplant Education
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplantation
Trial of Rituximab Given Pre-Transplant to Sensitised Live Donor Kidney Recipients
About one third of prospective kidney transplant recipients have antibodies in their blood directed against the tissues of their only available kidney donor.
- Trial name
- RAPTURE (NCT00371904)
- Testing
- Rituximab, Standard Care
- Where
- 3 sites in Australia
- Volunteers
- 192 people
- Sponsor
- Hunter and New England Health
Kidney Transplantation, Hepatitis C
The Use of Hepatitis C Positive Kidneys in Hepatitis C Negative Kidney Transplant Recipients
This is an open-label, pilot trial to test the safety and efficacy of transplantation of kidneys from hepatitis C seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative…
- Trial name
- NCT03809533
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Amit D Tevar, MD
Catheter-Associated Urinary Tract Infections (CAUTIs), Kidney Transplantation
Early (Postoperative Day 3) Versus Standard (Postoperative Day 6) Urethral Catheter Removal After Living Donor Kidney Transplantation
Urinary tract infection is one of the most common complications after kidney transplantation and is associated with increased morbidity, prolonged hospitalization, and impaired graft outcomes.
- Trial name
- (EARLY-KTx) (NCT07681843)
- Testing
- Early urethral catheter removal, Standard urethral catheter removal
- Where
- Israel
- Volunteers
- 172 people
- Sponsor
- Fahim Kanani
Kidney Transplant
The Effectiveness and Safety of Hypertonic Citrate Adenine-New (HCA-N) Solution for the Preservation of Kidney Grafts During Kidney Transplantation
To verify the effectiveness and safety of the HCA-N solution in actual clinical preservation, this study intends to conduct a prospective, randomized, and positive control clinical trial.
- Trial name
- NCT07825025
- Testing
- HCA-N Solution, HTK Solution
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhongnan Hospital
Endstage Kidney Disease
Implementing "Explore Transplant"- A Pilot Study
Patients with End Stage Kidney Disease (ESKD) require Renal Replacement Therapy (RRT) in order to survive, be it dialysis or kidney transplantation (KT).
- Trial name
- NCT03046732
- Testing
- Implementing "Explore Transplant" Education
- Where
- 2 sites in Canada
- Volunteers
- 227 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant Immunosuppression
Use of DNA Testing and Gene Expression Profiling to Help Transition Kidney Transplant Recipients to Belatacept-only Immunosuppression
The purpose of the study is to provide immunosuppression weaning and/or monitoring for an additional 12-months to evaluate the safety and efficacy of belatacept monotherapy in patients previously enrolled in the clinical trial…
- Trial name
- NCT06336863
- Testing
- Allosure and TruGraf, Immunosuppression Taper
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Transplant Rejection, Renal Transplant Failure
Heme Arginate in Transplantation Study
Organ shortage for transplant has necessitated use of kidneys from older donors, increasing the chance that the kidney will not work immediately or for as long as expected.
- Trial name
- HOT2 (NCT03646344)
- Testing
- Heme Arginate 25 MG/ML, 0.9% Sodium-chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Edinburgh
End Stage Renal Disease and Kidney Transplantation
Communicating About Choices in Transplantation
The purpose of this study is to test the impact of a newly developed educational program on kidney transplant candidates' communication about living and deceased donor kidney transplantation.
- Trial name
- COACH (NCT01853007)
- Testing
- COACH Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Living Liver and Kidney Donors
Living Organ Donor Recovery Enhancement Program
The purpose of the study is to test if using these living donor-specific pre-transplant resources would lead to a better and faster recovery post-transplant.
- Trial name
- NCT03865264
- Testing
- Recovery Enhancement Program
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
End Stage Renal Disease, Transplantation
Live Kidney Donor Study - Cross-Sectional and Historical Cohort Study
Kidney transplantation from living donors has been shown to carry many benefits over deceased donor transplantation. Because of benefits such as shorter waiting times and improved outcome for transplant recipients, living kidney…
- Trial name
- NCT00951977
- Where
- 3 sites in United States
- Volunteers
- 7,029 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Delayed Graft Function
ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function
The main purpose of this study is to evaluate the safety, efficacy and tolerability of ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function.
- Trial name
- VARVARA (NCT05907096)
- Testing
- ARGX-117
- Where
- 45 sites in United States, Australia and 9 more
- Volunteers
- 103 people
- Sponsor
- argenx
Renal Transplant Donor of Left Kidney, Renal Transplant Donor of Right Kidney
Fractures and Bone Disease in Living Kidney Donors
This research study is being done to measure bone health in living kidney donors and compare them to non-kidney donors to learn if living kidney donors have a higher risk of bone fractures (breaks) after kidney donation.
- Trial name
- NCT04810884
- Where
- United States
- Volunteers
- 4,415 people
- Sponsor
- Mayo Clinic