Clinical trials: Kidney Failure, Acute
End Stage Renal Disease, Acute Kidney Injury
Immunomodulatory Biomimetic Device to Treat Myocardial Stunning in End-stage Renal Disease Patients
Hemodialysis is a therapy that filters waste, removes extra fluid and balances electrolytes. In hemodialysis, blood is removed from the body and filtered through a man-made membrane called a dialyzer, and then the filtered blood…
- Conditions
- End Stage Renal Disease, Acute Kidney Injury, Chronic Kidney Disease Stage 5
- Trial name
- ESRD (NCT03539861)
- Testing
- Hemodialysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Aki After Ascending Aortic Surgeries
Effect of Dexmedetomidine on Acute Kidney Injury After Ascending Aortic Surgeries
Acute kidney injury (AKI) is a frequent and serious complication after ascending aortic surgeries requiring cardiopulmonary bypass (CPB).
- Trial name
- NCT06958367
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Acute Kidney Injury
Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation
Acute kidney injury (AKI), is a common complication of patients undergoing liver transplantation. Timing and definition of AKI, usually based on serum creatinine, have been inaccurate and inconsistent.
- Trial name
- AKIB (NCT02095431)
- Where
- Brazil
- Volunteers
- 122 people
- Sponsor
- University of Sao Paulo
Acute Kidney Injury
Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension
The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it
- Trial name
- NCT01554345
- Testing
- vitamin E +Selenium
- Where
- Iran
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Acute Kidney Injury, Pediatric Cardiac Surgery
The Effect of Preoperative Albumin Administration on Postoperative Acute Kidney Injury in Pediatric Patients With Hypoalbuminemia Undergoing Cardiac Surgery
The study aims to evaluate whether preoperative albumin supplementation in pediatric patients with hypoalbuminemia undergoing cardiac surgery can reduce inflammatory responses and prevent acute kidney injury (AKI) following…
- Trial name
- NCT06710353
- Testing
- Albumin solution, Crystalloid solutions
- Where
- South Korea
- Volunteers
- 190 people
- Sponsor
- Seoul National University Hospital
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Acute Kidney Injury
Ultra-Low Contrast Angiography in AKI
The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.
- Trial name
- NCT05906758
- Testing
- Angiography
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Acute Kidney Injury
The Optimal Mode of Renal Replacement Therapy in Acute Kidney Injury (OMAKI) Study
Acute kidney injury (AKI) in the intensive care unit is common, devastating and costly. However, minimal evidence exists to guide the prescription of optimal renal replacement therapy (RRT).
- Trial name
- OMAKI (NCT00675818)
- Testing
- Continuous venvenous hemofiltration (CVVH), Continuous venovenous hemodialysis (CVVHD)
- Where
- 5 sites in Canada
- Volunteers
- 78 people
- Sponsor
- Unity Health Toronto
Rhabdomyolysis, Myopathy
Study of the Causes of the Breakdown of Muscle Fibers in Hospitalized Patients
1. Analyze the various causes of breakdown of muscle fibers in hospitalized patients. 2. Analyze the characteristics of these patients in Taiwan (including the drugs history, risk factors and the incidence of complications).
- Conditions
- Rhabdomyolysis, Myopathy, Acute Renal Failure, Neuroleptic Malignant Syndrome
- Trial name
- NCT01022450
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately
Analysis of the Effect of Donor CYP3A5 Gene Polymorphism on Early Tacrolimus Concentration and Postoperative Acute Renal Injury After Liver Transplantation
Tacrolimus is the most commonly used immunosuppressant for preventing and treating rejection after liver transplantation. However, its treatment window is narrow, the pharmacokinetic individual differences are large, routine dose…
- Conditions
- Complete and Accurate Statistical Data of 60 Patients, CYP3A5*3 Genotypes of 60 Donors and Recipients Were Analyzed Accurately, Postoperative Tacrolimus Concentrations Were Accurately Recorded in 60 Patients, According to the Diagnosis and Grading Criteria of Acute Kidney Injury, the Cases and Grading of Postoperative Acute Kidney Injury in 60 Patients Were Counted
- Trial name
- NCT06319391
- Testing
- CYP3A5*1*、CYP3A5*1*3, CYP3A5*3*3
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ziqiang Li
Obstructive Sleep Apnea, Acute Kidney Failure
Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function
Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide.
- Conditions
- Obstructive Sleep Apnea, Acute Kidney Failure, Chronic Kidney Disease
- Trial name
- OSA-AKI (NCT00947479)
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Lodz
The Recipients Undergoing Liver Transplantation
Identification of Genetic Polymorphism Related to Acute Kidney Injury After Liver Transplantation Through Genome-wide Association Study (GWAS) in Korean Population
Some of the liver transplantation recipients experience postoperative acute kidney injury due to various causes including genetic factors.
- Trial name
- NCT03344380
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Acute Kidney Injury, Septic Shock
Targeting Abdominal Perfusion Pressure in Septic Shock
A randomized control trial among patients with septic shock, studying the incidence, progression and recovery of AKI.
- Conditions
- Acute Kidney Injury, Septic Shock, Resuscitations
- Trial name
- MAP-APP (NCT03582046)
- Testing
- Abdominal Perfusion Pressure (APP), Mean Arterial Pressure (MAP)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Potrero Medical
Glomerulonephritis, IGA, Kidney Diseases
Trial of Plasma Exchange for Severe Crescentic IgA Nephropathy
Crescentic IgA nephropathy (CreIgAN) has a poor prognosis despite aggressive immunosuppressive therapy. The efficacy of plasma exchange (PE) in CreIgAN is not well defined.
- Conditions
- Glomerulonephritis, IGA, Kidney Diseases, Acute Renal Insufficiency, Rapidly Progressive Glomerulonephritis
- Trial name
- RESCUE (NCT02647255)
- Testing
- Plasma Exchange (PE), Methylprednisolone pulse
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Peking University First Hospital
Cardiorenal Syndrome, Acute Kidney Injury
Effect on Kidney Function Recovery Guiding Decongestion With VExUS in Patients With Cardiorenal Syndrome 1
During cardiorenal syndrome type 1 (CRS1) vascular congestion is the major contributor to worsening renal function, but promoting decongestion with routine clinical evaluation is ineffective in some patients.
- Conditions
- Cardiorenal Syndrome, Acute Kidney Injury, Decompensated Heart Failure, Fluid Overload
- Trial name
- NCT05927285
- Testing
- Vexus, Control group
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital Civil de Guadalajara
Acute Kidney Injury
Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
The patients discharged from intensive care units (ICU) have a high incidence of cardiovascular events and mortality rate during the year following ICU discharge.
- Trial name
- START-or-NOT (NCT05272878)
- Testing
- IRBESARTAN, tablet, 150 mg
- Where
- France
- Volunteers
- 508 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury
The purpose of this protocol is to evaluate the safety of a selective cytopheretic device (SCD) in patients that are on continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- NCT01400893
- Testing
- SCD
- Where
- 26 sites in United States
- Volunteers
- 134 people
- Sponsor
- SeaStar Medical
Bacterial Infections
Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLED
Colistin was developed in the 1960s and preliminary pharmacokinetic studies were performed at that time. Dosing recommendations, on the basis of these pharmacokinetic studies, are listed in the drug's product information.
- Trial name
- NCT05586438
- Testing
- Colistin Sulfomethate
- Where
- Thailand
- Volunteers
- 13 people
- Sponsor
- Mahidol University
Acute Kidney Disease, Acute Kidney Injury
Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill.
- Trial name
- KARMA (NCT07052617)
- Testing
- Continuos renal replacement therapy
- Volunteers
- 2,500 people
- Sponsor
- Croatian Society for Organ Support
Liver Cancer, Adult
Risk Stratification and Proactive Nursing Intervention for Acute Kidney Injury Following Interventional Therapy in Patients With Liver Cancer
This study focuses on the early identification and precision prevention of acute kidney injury (AKI) following interventional therapy in patients with liver cancer.
- Trial name
- NCT07681817
- Testing
- Risk-stratified active nursing intervention group, Standard care (usual post-interventional nursing care)
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital