Clinical trials: Kidney Failure,Chronic
Chronic Kidney Disease
A Phase 2a Study of Weekly Doses of GCS-100 in Patients With Chronic Kidney Disease
The primary objective of this study is to compare the change in estimated glomerular filtration rate (eGFR) from baseline to Week 8 between placebo and GCS-100 treatment.
- Trial name
- NCT01843790
- Testing
- GCS-100
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- La Jolla Pharmaceutical Company
End Stage Renal Disease
Study of ChoironeX GalKO Porcine Thymokidney Xenotransplantation in End-Stage Renal Disease
The goal of this clinical trial is to learn if a GalKO Porcine Thymokidney can maintain renal function, without the need for dialysis, after transplantation into adult subjects with End Stage Renal Disease.
- Trial name
- NCT07696962
- Testing
- ChoironeX GalKO Porcine Thymokidney
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Xeno Holdings (US), LLC dba ChoironeX
Hepatitis C, Chronic Kidney Disease
Effect of Harvoni on Proteinuria and eGFR in Hepatitis C Virus Associated Chronic Kidney Disease (CKD)
Treatment protocol to see if people with hepatitis C (HCV) and chronic kidney disease (CKD) who are treated with Harvoni for 12 weeks have improvements in their kidney disease.
- Trial name
- NCT02503735
- Testing
- Sofosbuvir/Ledipasvir FDC
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease Associated Moderate to Severe Pruritus
To Evaluate the Efficacy and Safety of Nemolizumab for 12 Weeks in Participants With Chronic Kidney Disease With Associated Moderate to Severe Pruritus
The purpose of this study was to evaluate the efficacy of nemolizumab compared to placebo at reducing the intensity of pruritus after a 12-week treatment period in adult hemodialysis participants with moderate to severe pruritus.
- Trial name
- NIKAIA 1 (NCT05075408)
- Testing
- Nemolizumab
- Where
- 64 sites in United States, Hungary and 2 more
- Volunteers
- 258 people
- Sponsor
- Galderma R&D
Chronic Kidney Disease, End-Stage Renal Disease
House Calls and Peer Mentorship
Live donor kidney transplantation (LDKT) offers the most optimal survival and quality of life benefit for those with late-stage chronic kidney disease.
- Trial name
- HC+PM (NCT03354910)
- Testing
- House Call, Peer Mentorship
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hemodialysis, Thromboinflammation
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Hemodialysis-associated Thromboinflammation
This clinical trial investigates whether the composition of dialysate influences hemodialysis-associated thromboinflammation. Specifically, it evaluates the effects of magnesium concentration and acid type in dialysate on immune…
- Conditions
- Hemodialysis, Thromboinflammation, Hemodialysis Complication, End Stage Renal Disease (ESRD)
- Trial name
- pilot OMAGOD + (NCT07206524)
- Testing
- Hemodialysis using dialysate containing citric acid and magnesium at a concentration of 1.0 mmol/L, Hemodialysis using acetic acid dialysate with magnesium 0.5 mmol/L, Hemodialysis using citric acid dialysate with magnesium 0.75 mmol/L
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Kidney Diseases
The Efficacy of Physical Activity on Improving Health Outcomes for Renal Transplant Patients
The purpose of this study is to see whether a physical activity intervention improves fitness, strength and reduces sedentary behavior.
- Trial name
- NCT04054323
- Testing
- Physical Activity Intervention
- Where
- United States
- Sponsor
- University of Pittsburgh
Heart Failure, Systolic, Heart Failure, Diastolic
Implementation of Telerehabilitation In Support of HOme-based Physical Exercise for Heart Failure
ITISHOPE4HF is a randomized controlled trial of telerehabilitation in a heart failure population. The goal is to evaluate if a home-based telerehabilitation project can increase physical activity in heart failure patients.
- Conditions
- Heart Failure, Systolic, Heart Failure, Diastolic, Chronic Kidney Diseases, Cardiorenal Syndrome
- Trial name
- ITISHOPE4HF (NCT03183323)
- Testing
- Telerehabilitation
- Where
- Norway
- Volunteers
- 61 people
- Sponsor
- Helse Nord-Trøndelag HF
Kidney Failure, Chronic
Piloting an Intervention for Improving Treatment Adherence
Helping patient with long-term conditions to make informed decisions about adherence to their treatment is an important element in facilitating self-management.
- Trial name
- NCT02250235
- Testing
- Health risk information
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Hertfordshire
End-Stage Renal Disease, Hemodialysis
Pharmacokinetics And Dialysability Of CP-690,550 In Subjects With End-Stage Renal Disease
There were 2 study periods in this study. In the Period 1, CP-690,550 was to be administered approximately 1 to 2 hours following hemodialysis.
- Trial name
- NCT01710020
- Testing
- CP-690,550
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pfizer
End Stage Renal Disease, Renal Anemia
Comparison of Epoetin Alfa and Epoetin Omega in Anemic Dialysis Patients:Results of Efficacy Trial
The two epoetins, Epoetin alfa, a well established drug to treat renal anemia and Epoetin Omega, that differs from Epoetin alfa in the sugar moiety of the molecule were compared in regard of efficacy and safety to treat end stage…
- Conditions
- End Stage Renal Disease, Renal Anemia, Regular Dialysis Treatment
- Trial name
- NCT00322413
- Testing
- Epoetin
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- General Hospital Sveti Duh
Chronic Kidney Disease
Circadian Rhythm of Erythropoietin And Melatonin in Renal Disease
Rationale: Investigation of the circadian rhythm of erythropoietin and melatonin in patients with various degrees of renal insufficiency Objectives: Primary objective: Is there a circadian rhythm of epo and melatonin in patients…
- Trial name
- CREAM 1 (NCT00698360)
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Meander Medical Center
Kidney Disease, Chronic
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study.
- Trial name
- NCT06531824
- Testing
- BI 690517, Empagliflozin
- Where
- 562 sites in United States, Argentina and 18 more
- Volunteers
- 8,371 people
- Sponsor
- Boehringer Ingelheim
Peritoneal Dialysis-associated Peritonitis
Defining the Optimal Duration of Treatment for "Low-Risk" Peritoneal Dialysis-Related Peritonitis
Background According to the International Society for Peritoneal Dialysis (ISPD) recommendations, "low-risk" peritoneal dialysis (PD)- related peritonitis caused by coagulase-negative staphylococcal species, Streptococcal…
- Trial name
- NCT03675854
- Testing
- Cefazolin
- Where
- Hong Kong
- Sponsor
- Chinese University of Hong Kong
Chronic Kidney Diseases, Cardiovascular Diseases
BLOOM: Biological Legacy of Origin in Mother-Infant Dyads
Infants born preterm and of low birth weight are known to be at increased risk for early onset of cardiovascular and renal disease in adult life.
- Trial name
- NCT02000895
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Miami
Anemia
A Study of Epoetin Beta (NeoRecormon) in Anemic Participants With Diabetes and Chronic Renal Failure Who Are Not on Dialysis
This study will evaluate the effect of epoetin beta (NeoRecormon) on correction of anemia and quality of life in participants with diabetes and chronic renal failure and who are not receiving dialysis.
- Trial name
- NCT02827266
- Testing
- Epoetin beta
- Where
- 78 sites in France
- Volunteers
- 122 people
- Sponsor
- Hoffmann-La Roche
End Stage Renal Failure on Dialysis
Impact of Cold Dialysis in Combination With Intradialytic Exercise in Aspects Related to Quality of Life and Health
Despite the tremendous advances in dialysis technology, hemodialysis (HD) is a significant challenge for dialysis patients and quality of their lives[2].
- Trial name
- REACD (NCT03905551)
- Testing
- Cold Dialysis, Typical Dialysis, Exercise
- Where
- 3 sites in Greece
- Volunteers
- 72 people
- Sponsor
- University of Thessaly
Chronic Kidney Disease - Stage V
Adipose Tissue & Uremia
Many metabolic disturbances, such as protein-energy wasting, inulin resistance, and dyslipidemia are common features of chronic kidney disease (CKD).
- Trial name
- MODAIR (NCT02902705)
- Testing
- Biopsy of abdominal subcutaneous white adipose tissue (2-3 g)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
End Stage Renal Failure, Hemodialysis, Cannulation
Guided Needle Insertion for Vascular Access
The goal of this clinical trial is to determine whether the study device can assist the cannulator with placing two needles during cannulation required to initiate dialysis treatment.
- Trial name
- ACCESS 2 (NCT07548151)
- Testing
- Ultrasound-Guided, Power-Assisted Needle Insertion
- Where
- Uzbekistan
- Volunteers
- 10 people
- Sponsor
- X9, Inc.
Chronic Kidney Disease, Proteinuria
Sitaxsentan in Proteinuric Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have higher blood pressures than the general population. They also tend to have protein leaking into the urine (proteinuria).
- Conditions
- Chronic Kidney Disease, Proteinuria, Blood Pressure
- Trial name
- NCT00817037
- Testing
- Sitaxsentan, Nifedipine
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
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