Clinical trials: Kidney Failure,Chronic
Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury
SIRAKI 02 Posthoc Analysis.
Our randomized controlled trial with 343 patients requiring non emergent cardiac surgery with a prolonged expected cardiopulmonary bypass (CPB) time (>90 minutes) demonstrated that the use of an extracorporeal blood purification…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Acute Kidney Injury, Chronic Kidney Disease(CKD), Kidney Failure, Acute
- Trial name
- OXI-SAFE-CEC (NCT06781294)
- Testing
- Extracorporeal Cytokine hemadsorption therapy
- Where
- Spain
- Volunteers
- 343 people
- Sponsor
- Hospital Universitari de Bellvitge
Renal Insufficiency, Chronic, Heart Failure With Preserved Ejection Fraction
Chronic Kidney Disease and Heart Failure With Preserved Ejection Fraction: The Role of Mitochondrial Dysfunction
The purpose of this study is to investigate the role of mitochondrial derived oxidative stress on exercise capacity and arterial hemodynamics in HFpEF patients with and without chronic kidney disease.
- Trial name
- NCT03960073
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Virginia Commonwealth University
Acute Renal Failure
Efficacy of Erythropoietin to Prevent Acute Kidney Injury in Chronic Kidney Disease Patients Undergoing Cardiac Surgery
The purpose of this study is to demonstrate the efficacy of erythropoietin for prevention acute kidney injury in CKD patients undergoing cardiac surgery.
- Trial name
- NCT01066351
- Testing
- beta erythropoietin
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Thammasat University
Contrast Induced Nephropathy
Statins for Prevention of Contrast Induced Nephropathy
In this randomized study the investigators wish to explore the role of pre-procedural statin therapy for the prevention of contrast induced nephropathy in patients with moderate-to-severe renal dysfunction, submitted to elective…
- Trial name
- NCT00770796
- Testing
- Atorvastatin
- Volunteers
- 304 people
- Sponsor
- Ospedale Misericordia e Dolce
Chronic Kidney Disease Mineral and Bone Disorder, Hypertension
Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD
The overall objective of this pilot randomized clinical trial is to determine whether low-dose Colchicine (LoDoCo) improves vascular disease including vascular calcification, peripheral arterial disease (PAD), and chronic kidney…
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Hypertension, Diabetes, Dyslipidemia
- Trial name
- RESOLVE-CKD (NCT07654231)
- Testing
- Low-dose Colchicine at 0.5mg daily, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Transplant;Failure,Kidney, Kidney Disease
APOL1 Gene Variants in African American Kidney Transplant Recipients
Aim 1: Determine if there is an association between the APOL1 risk variants and allograft survival and function in African Americans Aim 2: Determine if there is an association between the presence of APOL1 risk variants in an…
- Conditions
- Transplant;Failure,Kidney, Kidney Disease, Kidney Failure, Chronic
- Trial name
- NCT01442402
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Essential Hypertension
Autonomic Imbalance and 24-h Blood Pressure Change in Patients With Chronic Renal Disease
Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood.
- Conditions
- Diabetes Mellitus, Essential Hypertension, Renal Failure, Chronic Nephropathy
- Trial name
- NCT00298129
- Testing
- Ambulatory blood pressure monitoring
- Where
- Japan
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- Yokohama City University Medical Center
Kidney Failure, Chronic, Renal Insufficiency, Chronic
A Study of LY2409021 in Participants With Different Levels of Kidney Function
The purpose of this study was to measure how much of the study drug, LY2409021, gets into the blood stream and how long it takes the body to get rid of it when given to participants with different levels of kidney function.
- Trial name
- NCT01929109
- Testing
- LY2409021
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Chronic Kidney Disease, Disability
Dietary Acid Load, Kidney Function and Disability in Elderly
The purpose of this research study is to determine the effect of a bicarbonate supplement on kidney function and physical function.
- Trial name
- BICARB (NCT02691663)
- Testing
- Oral bicarbonate supplementation
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Wake Forest University Health Sciences
Quality of Life, Mental Health Wellness 1
QOL and Mental Health Using APD With Remote Monitoring System
Although peritoneal dialysis (PD) is a representative renal replacement therapy along with hemodialysis, number of PD patients decreases every year.
- Trial name
- NCT07012499
- Testing
- Automated peritoneal dialysis with Sharesource device, APD without sharesource
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Wonju Severance Christian Hospital
Chronic Kidney Disease, Probiotics
The Effect of Probiotics on Chronic Kidney Disease
Probiotics could attenuate renal function deterioration in CKD patients.
- Conditions
- Chronic Kidney Disease, Probiotics, Renal Function
- Trial name
- NCT03228563
- Testing
- Probioics
- Where
- Taiwan
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Secondary Hyperparathyroidism
ACHIEVE: Optimizing the Treatment of Secondary Hyperparathyroidism
The purpose of this study is to compare the proportion of chronic kidney disease (CKD) subjects on dialysis receiving Sensipar® and low dose vitamin D or escalating doses of vitamin D alone who are able to achieve the National…
- Trial name
- NCT00135304
- Testing
- Sensipar®, Vitamin D
- Volunteers
- 170 people
- Sponsor
- Amgen
End-stage Kidney Disease, Brain Damage
Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease
End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients.
- Trial name
- NCT03191409
- Where
- 2 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Uncontrolled Hypertension, Renal Denervation
Renal Denervation in Chronic Kidney Disease - RDN-CKD Study
RDN-CKD GR Study is a prospective, randomized (1:1), double-blind (unblinded interventionalist and blinded study team), sham controlled study.
- Conditions
- Uncontrolled Hypertension, Renal Denervation, Chronic Kidney Disease (Stage 3)
- Trial name
- RDN-CKD GR (NCT07742787)
- Testing
- Renal denervation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Hippocration General Hospital
End Stage Renal Disease (ESRD), Kidney Failure
A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease
The goal of the CSP-2002 clinical trial is to evaluate the safety and effectiveness of the InnAVasc Arteriovenous Graft (IG) for hemodialysis (HD) access in patients with end-stage renal disease (ESRD).
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic Renal Disease, Hemodialysis
- Trial name
- NCT04671771
- Testing
- InnAVasc Arteriovenous Graft (IG) surgical implant
- Where
- 22 sites in United States
- Volunteers
- 133 people
- Sponsor
- W.L.Gore & Associates
End-stage Renal Disease, Renal Replacement Therapy
Renal Replacement Therapies Decision Aids
Different renal replacement therapy methods will cause significant impacts on the physical, mental, and social for patients with end-stage renal disease.
- Conditions
- End-stage Renal Disease, Renal Replacement Therapy, Decision Aid, Decision-making
- Trial name
- NCT05666544
- Testing
- Web-based patient decision aid, Written health education leaflets
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- China Medical University Hospital
Chronic Kidney Disease, Albuminuria
Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease
Vascular endothelial dysfunction increases cardiovascular (CV) risk and contributes to the progression of chronic kidney disease (CKD).
- Trial name
- VEMAKD (NCT02497300)
- Testing
- Spironolactone, Amiloride
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, End Stage Renal Disease
Modulation of Inflammation by Medium Cut Off Membranes
This study examines whether medium-cut off dialysis results in improved blood purification of large middle molecules e.g. inflammatory molecules compared to hemodialysis (HD) treatments with conventional high-flux dialyzers.
- Trial name
- MCO-IF (NCT03270371)
- Testing
- Medium cut off dialysis, Standard High Flux Dialyzer
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Heart Failure, Volume Overload
Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)
Researchers are observing the values of proEnkephalin (PENK) via a blood draw in hospitalized patients that are volume overloaded requiring diuresis.
- Conditions
- Heart Failure, Volume Overload, Decompensated Heart Failure, Systolic Heart Failure
- Trial name
- NCT04019314
- Testing
- Blood Collection, Blood Volume Analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease
Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)
This phase III trial compares the effect of adding tocilizumab to standard of care versus standard of care alone in treating cytokine release syndrome (CRS) in patients with SARS-CoV-2 infection.
- Conditions
- Cerebrovascular Accident, Chronic Obstructive Pulmonary Disease, Chronic Renal Failure, Coronary Artery Disease
- Trial name
- NCT04361552
- Testing
- Best Practice, Tocilizumab
- Where
- United States
- Sponsor
- Emory University
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