Clinical trials: Kidney Failure,Chronic
End-stage Renal Disease
Efficacy Trial of Fluid Distribution Timetable
Nonadherence to fluid restriction is a significant issue among hemodialysis patients globally, with numerous adverse health outcomes.
- Trial name
- NCT05797766
- Testing
- Fluid Distribution Timetable
- Where
- Philippines
- Volunteers
- 40 people
- Sponsor
- University of Santo Tomas
End-stage Renal Disease
Solute Removal With High Volume Hemodiafiltration Versus Long High Flux Hemodialysis
This is a prospective cross-over study including 10 stable hemodialysis patients with chronic kidney disease stage 5. The cross-over study lasts 2 weeks with the study dialysis sessions at midweek.
- Trial name
- NCT01445366
- Testing
- High volume post dilution hemodiafiltration, high flux hemodialysis
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Ghent
Chronic Kidney Diseases
LONGitudinal Multi-omics Phenotyping of KIDney Function Alteration
This is a longitudinal observation of kidney function, immune system and gut microbiota before and 24 weeks after a live kidney transplantation conducted in donor and recipient pairs living in the same household.
- Trial name
- NCT05570929
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Coronary Artery Disease, Diabetes Mellitus
Study Design of 'Influence of Sarpogrelate in Patients With Renal Impairment or Diabetes Mellitus' Study
The purpose of the SERENADE trial is to evaluate the safety and efficacy of sarpogrelate in patients with CKD or DM after DES implantation.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- SERENADE (NCT02294643)
- Testing
- Sarpogrelate, Aspirin, Clopidogrel
- Where
- South Korea
- Volunteers
- 220 people
- Sponsor
- Seoul National University Bundang Hospital
Chronic Kidney Disease(CKD)
CKD-Heart: Heart Failure Prediction in Asian CKD Patients
Among patients with known chronic kidney disease (CKD) who are free from diagnosed heart failure (HF), some may be classified as stage A-B HF based on the contemporary 2022 ACC/AHA Guideline for Heart Failure Classification.
- Trial name
- NCT06677489
- Where
- Taiwan
- Volunteers
- 1,000 people
- Sponsor
- Mackay Memorial Hospital
Chronic Kidney Insufficiency, Sleep Apnea
Effect of CPAP in the Worsening of Renal Function in Early Stages of Chronic Kidney Disease (CKD)
Objectives: Evaluate the effect of CPAP to reduce the progression of chronic kidney disease or CKD (the decline of glomerular filtration rate is ≥ 30%) in patients with early-stage renal disease and sleep apnea syndrome (OSAS).
- Trial name
- Renas (NCT03319888)
- Testing
- CPAP, conservative treatment
- Where
- Spain
- Volunteers
- 700 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Healthy Volunteers, Chronic Kidney Disease
A Study of RBT-9 in Healthy Volunteers and Volunteers With Stage 3/4 Chronic Kidney Disease
This is a Phase 1b, single-center, dose-escalating study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic effect of RBT-9 in healthy volunteers and in subjects with Stage 3/4 CKD.
- Trial name
- NCT04072861
- Testing
- RBT-9
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Renibus Therapeutics, Inc.
End Stage Renal Disease
Pharmacokinetics and Pharmacodynamics of Apixaban in Subjects on Hemodialysis
The purpose of this study is to assess the pharmacokinetics of a single oral dose of 5 mg Apixaban in subjects with normal renal function and subjects with end stage renal disease (ESRD) maintained with hemodialysis.
- Trial name
- NCT01340586
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Kidney Diseases, Chronic, Glomerular Diseases
Model Development and Application Based on Renal Pathology Images
This single-center retrospective observational cohort study will utilize digital renal pathology images along with corresponding clinical and laboratory data from patients who underwent kidney biopsy at Union Hospital, Tongji…
- Conditions
- Kidney Diseases, Chronic, Glomerular Diseases, Tubulointerstitial Kidney Diseases, IgA Nephropathy (IgAN)
- Trial name
- NCT07816874
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Primary Hyperoxaluria Type 1, End Stage Renal Disease
Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD
The aim of this study is to evaluate DCR-PHXC in participants with PH1 and severe renal impairment, with or without dialysis.
- Trial name
- PHYOX7 (NCT04580420)
- Testing
- DCR-PHXC
- Where
- 18 sites in United States, France and 8 more
- Volunteers
- 28 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company
Chronic Kidney Disease, End Stage Renal Disease
Chronic Kidney Disease Prevention of An-Lo District, Keelung
The prevalence and the incidence of the end-stage renal disease (ESRD) are extremely high in Taiwan (1, 2). More than 45,000 patients are under renal replacement therapy in the year 2004 (2).
- Conditions
- Chronic Kidney Disease, End Stage Renal Disease, Death
- Trial name
- NCT00644046
- Testing
- multidisciplinary predialysis education
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Chronic Kidney Diseases
Enhancing Physical Function in Older Adults With Chronic Kidney Disease
The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to…
- Trial name
- EPIC (NCT06738394)
- Testing
- High-Velocity Resistance Training, Attention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Chronic Renal Disease
Effects of Low Protein Formula on Renal Function, Oxidative Stress and Antioxidant Capacities in CKD Patients
Chronic renal disease is now the tenth leading cause of mortality Taiwan. It is worth to study the effect of low protein formula on the retardation of failing renal function, decrease plasma homocysteine and oxidative stress and…
- Trial name
- NCT01999023
- Testing
- Low protein formula group
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taichung Veterans General Hospital
Chronic Kidney Disease (Stage 3-4)
Effect of Synbiotic Therapy on Renal Function Outcomes in Patients With Chronic Kidney Disease Stage III-IV: A Double-blind Randomized Placebo-controlled Trial.
Background: Chronic kidney disease (CKD) represents a growing global public health challenge, with rising prevalence in low and middle-income countries, including Bangladesh.
- Trial name
- NCT07912359
- Testing
- Experimental arm will get synbiotic therapy containing Lactobacillus acidophilus (15 billion CFU), Bifidobacterium longum (15 billion CFU), Streptococcus thermophilus(15 billion CFU), along with xylo
- Where
- Bangladesh
- Volunteers
- 96 people
- Sponsor
- Chittagong Medical College
Chronic Kidney Diseases
Kidney Health: Eat Well, Live Well
This two-arm, parallel randomized trial study will assess the efficacy of a 6-month (26 weeks) community-based program in reducing kidney injury (as Urine Albumin to Creatinine ratio, uACR), cardiovascular risk (as Hemoglobin A1C…
- Trial name
- NCT05970341
- Testing
- 1. Welcome package, 2. Welcome information (phone or text), 3. Produce delivery + Recipes customized to produce
- Where
- 3 sites in United States
- Volunteers
- 330 people
- Sponsor
- University of Texas at Austin
END STAGE RENAL DISEASE
ESTEROID WITHDRAWAL STUDY, SAFETY AND EFFICACY IN RENAL TRANPLANTATION
BACKGROUND: Non-steroid maintenance immunosuppression after transplantation can improve long-term lipid and hemodynamic profiles without severe acute rejection (AR) events that alter graft function or survival.
- Trial name
- ESWMEX001 (NCT02328222)
- Testing
- ESW group
- Where
- Mexico
- Volunteers
- 71 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Renal Dialysis, Health Literacy Level
Impact of Hospital Pharmacist Intervention on Medication Management in Dialysis Patients
The goal of this clinical trial is to learn if an intervention of a hospital pharmacist could help, dialysis patients managed his treatment. In a first time, the health literacy level will be assed.
- Conditions
- Renal Dialysis, Health Literacy Level, Kidney Disease, Chronic
- Trial name
- IPhaDia (NCT06692231)
- Testing
- Pharmacist intervention
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier de Vichy
Uremic Pruritus
Using of Extra Virgin Olive Oil in Hemodialysis Patients to Improve Pruritus and Sleep Disorders
Background and Purpose: Itching is a common complication of hemodialysis patients, which can cause skin damage and affect the patient's comfort.
- Trial name
- NCT05466045
- Testing
- Olive oil application in hemodialysis patients with pruritus, Normal saline application in hemodialysis patients with pruritus
- Volunteers
- 86 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Chronic Kidney Diseases
Set-up of a Platform for Personalized Diagnosis of Rare Kidney Diseases (NIKE)
Chronic kidney disease (CKD) is a major health problem, with steadily increasing incidence and prevalence and the threat of a true "epidemic".
- Trial name
- NCT06325072
- Testing
- Conclusive genetic testing, Genotype-phenotype correlation for personalized diagnosis, Personalized study of variants of uncertain clinical significance (VUS) through functional studies on 3D organ-on-a-chip
- Where
- 4 sites in Italy
- Volunteers
- 160 people
- Sponsor
- Meyer Children's Hospital IRCCS
Heart Transplantation, Chronic Renal Insufficiency
Genetic Predictors of Renal Dysfunction Following Heart Transplantation
Kidney disease is a common problem after heart transplantation. It may be caused by anti-rejection medications such as cyclosporine or tacrolimus.
- Trial name
- NCT01686191
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
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