Clinical trials: Kidney Failure,Chronic
END STAGE RENAL DISEASE
A Pilot Study to Evaluate ZADAXIN's® (Thymalfasin) Ability to Enhance Immune Response to the H1N1sw Influenza Vaccine
The purpose of this explorative trial is to collect preliminary data on efficacy and safety of thymosin alpha 1 given at different doses as an adjuvant to egg-derived H1N1sw monovalent influenza vaccine in hemodialysis patients.
- Trial name
- NCT01031966
- Testing
- MF59 adjuvanted H1N1 influenza monovalent vaccine, Thymosin alpha 1
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Chronic Kidney Disease
Genotype and Platelet Reactivity in Patients on Hemodialysis
Patients with end stage renal disease (ESRD) on hemodialysis (HD) exhibited higher platelet reactivity to clopidogrel than did those with normal renal function.
- Trial name
- NCT02394145
- Testing
- Ticagrelor, Clopidogrel
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Kyunghee University Medical Center
Hemodialysis, End-stage Renal Disease
Mechanisms and Treatment of Intradialytic Hypertension - Sodium
The purpose of this study is to determine the role of dialysate exposure and fluid removal during hemodialysis in the pathophysiology of intradialytic hypertension.
- Conditions
- Hemodialysis, End-stage Renal Disease, Hypertension, Intradialytic Hypertension
- Trial name
- MATCH-Sodium (NCT01371890)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Disease
Pilot Study of Health Information Technology for Chronic Kidney Disease Management
Researchers now know that treating chronic kidney disease (CKD) in its early stages can prevent dialysis and reduce heart problems that go along with kidney disease.
- Trial name
- NCT02990897
- Testing
- clinical decision support message
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Disease, Stage IV (Severe), Chronic Kidney Disease, Stage V
The Study of Immunogenicity of Quadrivalent Vaccine Against Human Papilloma Virus (HPV) Types 6, 11, 16, and 18 (HPV-6/11/16/18) in Chronic Kidney Disease (CKD) Patients
Clinical trials have demonstrated the efficacy of HPV-6/11/16/18 vaccination (Gardasil. Merck) 3 doses at day 1, month 2, and month 6 to lower the occurrence of high-grade cervical intraepithelial neoplasia than did those in the…
- Trial name
- NCT01298869
- Testing
- HPV-6/11/16/18 vaccine
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Chulalongkorn University
Kidney Disease, Chronic, Diabetes
Effect of SGLT2i on Cardiovascular Biomarkers in Patients With Type 2 Diabetes and CKD Stage 3b-4
This is a prospective, observational study to assess the effect of SGLT2 inhibitors on surrogate markers of kidney and cardiovascular health in patients with stage 3b and 4 chronic kidney disease (CKD).
- Trial name
- NCT05033054
- Testing
- SGLT2 inhibitor
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Texas Southwestern Medical Center
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Chronic Kidney Disease, Heart Failure With Reduced Ejection Fraction (HFrEF)
Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure
This study compares the effects of once-daily versus twice-daily ramipril dosing on renal function in chronic kidney disease (CKD) patients with heart failure with reduced ejection fraction (HFrEF).
- Trial name
- NCT07259512
- Testing
- Ramipril
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Evi Liliek Wulandari
Diabetes, Cardiovascular Diseases
The Manitoba Personalized Lifestyle Research (TMPLR) Study
Lifestyle factors, such as diet, physical activity and sleep, are associated with the development of many chronic diseases. The objective of The Manitoba Personalized Lifestyle Research (TMPLR) study is to understand how these…
- Conditions
- Diabetes, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- NCT03674957
- Where
- Canada
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Kidney Failure, Chronic, Diabetic Nephropathies
Effects of Rituximab and Mycophenolate Mofetil (MMF) on Highly Sensitized Patients Awaiting Renal Transplant
This is a 12-month phase 2, prospective, open label study to evaluate the effect of rituximab with mycophenolate mofetil (MMF)on the PRA of 14 highly sensitized patients who just completed an 8 month trial of MMF treatment alone.
- Conditions
- Kidney Failure, Chronic, Diabetic Nephropathies, Glomerulonephritis, IGA, Hypertension, Renal
- Trial name
- NCT00446251
- Testing
- Rituximab, Mycophenolate mofetil (MMF)
- Volunteers
- 14 people
- Sponsor
- University of Washington
Vitamin D Deficiency, End Stage Renal Disease
A Study of Fixed Dose Versus Serum Level-Based Titration Regimen of Vitamin D Supplementation in Dialysis Patients
Vitamin D insufficiency, defined as serum 25-hydroxyvitamin (OH) D level less than 30 ng/ml, is highly prevalent not only in the general population but also in chronic kidney disease (CKD) population.
- Trial name
- NCT05434377
- Testing
- ergocalciferol supplementation, dialysis techniques, sunlight exposure time
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- Chulalongkorn University
End Stage Renal Disease, End-Stage Kidney Disease
Prognostic Value of Finger Blood Pressure in Arteriovenous Fistula Care
The goal of this trial is to investigate the prognostic value of monitoring finger blood pressures (FBPs) in predicting the success of surgically created arteriovenous fistula (AVF) for patients with end stage renal disease.
- Conditions
- End Stage Renal Disease, End-Stage Kidney Disease, Dialysis Access Dysfunction
- Trial name
- NCT06765577
- Testing
- Finger Blood Pressure Measurement
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Singapore General Hospital
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study to Learn More About How Safe Finerenone is and How Well it Works in People With Chronic Kidney Disease and Type 2 Diabetes in Routine Medical Care in the United States
This is an observational study in which data from people with chronic kidney disease (CKD) and Type 2 diabetes mellitus (T2D) are collected and studied.
- Trial name
- 22663 (NCT06608212)
- Testing
- Finerenone (Kerendia, BAY948862), Others except finerenone
- Where
- United States
- Volunteers
- 238,038 people
- Sponsor
- Bayer
Hemodialysis, Chronic Kidney Disease
Comparison of Body Hydration State in Hemodialysis Patients
Estimation of hydration state in dialysis patients is a major challenge in clinical practice. Although many methods have been studied, none have been established yet for clinical routine practice.
- Trial name
- NCT01814254
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Renal Research Institute
ANCA Associated Vasculitis
Multicenter Cohort Study of AAV in Hunan of China
This study aimed to explore the incidence of Anti-neutrophil cytoplasmic antibody (ANCA）-associated vasculitis (AAV) progression and its association with adverse consequences.
- Trial name
- NCT05315141
- Testing
- No Intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangya Hospital of Central South University
Chronic Kidney Disease, Decision-making
A Video Decision Support Tool to Assist Elderly Patients in ESRD Treatment Decision-making
In the United States, it is estimated that there are approximately 630,000 patients who have ESRD with two-thirds of those patients subsequently receiving maintenance dialysis.
- Trial name
- NCT02698722
- Testing
- End-stage renal disease treatment options
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Diseases, COVID-19
COVID-19 Vaccine Boosters in Patients With CKD
This study is a 12-month, four-arm parallel-group randomized control trial of Pfizer-BioNTech versus MODERNA COVID-19 (Corona Virus disease 2019)vaccine boosters in chronic kidney disease and dialysis patients with poor humoral…
- Trial name
- BOOST KIDNEY (NCT05022329)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine, MODERNA SARS-CoV-2 Vaccine
- Where
- 3 sites in Canada
- Volunteers
- 273 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Kidney Disease, Vitamin D Deficiency
Vitamin D and Coronary Calcification Study
Patients with chronic kidney disease (CKD) have a higher mortality rate than the general population, with cardiovascular disease (CVD) accounting for approximately 50% of deaths.
- Conditions
- Chronic Kidney Disease, Vitamin D Deficiency, Coronary Calcification, Disorders of Calcium and Bone Metabolism
- Trial name
- VCOR (NCT00752102)
- Testing
- Calcitriol (Rocaltrol®), Paricalcitol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Joslin Diabetes Center
End Stage Renal Disease
Conventional Hemodialysis Vs Short Daily Hemodialysis for Patients Coming From Peritoneal Dialysis (HAPD/CAPD)
The purpose of this randomized study is to determine if the home SDHD is a suitable alternative to conventional dialysis performed in a dialysis center for patients suffering from chronic kidney disease from Peritoneal Dialysis…
- Trial name
- CHDvsSDHD (NCT02002949)
- Testing
- Short daily hemodialysis, Conventional hemodialysis
- Where
- 31 sites in Italy
- Volunteers
- 144 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Renal Failure Chronic Requiring Hemodialysis, Poor Quality Sleep
BIA-Guided Dry Weight Assessment on Sleep Quality in Chronic Hemodialysis Patients
Based on many previous data proving hypervolemia in chronic hemodialysis patients could lead to sleep apnea and poor sleep quality.
- Trial name
- BEDTIME (NCT02825589)
- Testing
- BIA
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University
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