Clinical trials: Kidney Functional
Renal Impairment
Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function
This study is evaluating the Pharmacokinetics of MNTX in healthy control subjects and in patients with mild, moderate, or severe renal impairment who do not require hemodialysis.
- Trial name
- NCT01367509
- Testing
- Methylnaltrexone (MNTX)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Hydronephrosis
Clinical Significance of Supranormal Differential Renal Function in the Recovery of Hydronephrosis
The purpose of this study is to assess the clinical significance of supranormal differential renal function (DRF) in the recovery of unilateral hydronephrosis (HN) after surgery, pediatric patients who underwent pyeloplasty for…
- Trial name
- NCT01839006
- Testing
- dismembered pyeloplasty
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Ketosis, Ketonemia
Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity in Healthy Subjects
This is a randomized, placebo-controlled, double-blinded crossover design. Fifteen healthy subjects will be randomized to receive either ketone bodies (KE4) or placebo delivered by KetoneAid.
- Trial name
- KETO (NCT05980858)
- Testing
- Beta-hydroxybutyrate
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gødstrup Hospital
Kidney Disease, Proteinuria
Determination of Kidney Function
Much more about kidney disorders can be learned by determining kidney function. This research proposes to study the kidneys function by several parameters known as glomerular filtration rate (GFR), Renal Plasma Flow (RPF), and…
- Conditions
- Kidney Disease, Proteinuria, Autoimmune / Connective Tissue Diseases
- Trial name
- NCT00001978
- Where
- United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Chronic Renal Insufficiency, Hemodialysis
Effect of a Concurrent Physical Exercise Program in Hemodialysis Patients
Concurrent physical exercise is the method of combining strength and endurance that can be worked with in one session or in an exercise program.
- Trial name
- NCT06664385
- Testing
- concurrent physical exercise
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pedro Julian Flores Moreno
Renal Cell Carcinoma
Investigating a Novel Modifiable Factor Affecting Renal Function After Partial Nephrectomy: Cortical Renorrhaphy
Preserving kidney function during removal of a kidney tumor is becoming increasingly important as rates of chronic kidney disease increase.
- Trial name
- NCT02131376
- Testing
- Non-renorrhaphy, Renorrhaphy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Indiana University
Hepatorenal Syndrome, Cirrhosis, Liver
Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury
Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF…
- Conditions
- Hepatorenal Syndrome, Cirrhosis, Liver, Acute-On-Chronic Liver Failure, AKI
- Trial name
- NCT05434286
- Testing
- Echocardiographic assessment
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Arterial Hypertension, Resistant Arterial Hypertension
Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation
It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improvement in vascular reactivity and…
- Trial name
- NCT03243045
- Testing
- Renal sympathetic denervation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Kidney Failure, Chronic
Saving Residual Renal Function Among Haemodialysis Patients Receiving Irbesartan
Angiotensin II receptor blockers (ARB) are known to preserve kidney function among patients with kidney diseases and reduced renal function, but not among haemodialysis patients.
- Trial name
- SAFIR (NCT00791830)
- Testing
- Irbesartan
- Where
- 6 sites in Denmark
- Volunteers
- 82 people
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus (T2DM), Renal Insuficiency
The Pharmacokinetics Study of Fotagliptin in Patients with Different Degrees of Renal Insufficiency
The trial was designed in a single dose, open, non-randomized, multi-dose parallel control group. The study of patients were mild and moderate renal insufficiency, and matched healthy subjects.
- Trial name
- RI (NCT06883656)
- Testing
- SAL067
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Heart Failure With Preserved Ejection Fraction, End Stage Renal Disease on Dialysis
EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease
The presence of CKD has been linked to the development of HFpEF. Currently, the treatment for HFpEF is limited. SGLT2i are one of the few drug classes that have proven efficacy in HFpEF in randomized controlled trials.
- Trial name
- EMPA-PRED (NCT06249945)
- Testing
- Empagliflozin 25 MG
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Chronic Renal Failure, Kidney Transplantation
Fluid Intake in Kidney Failure
Patients with renal impairment are usually advised to increase their fluid intake. There is currently, however, no evidence supporting this recommendation.
- Trial name
- NCT00842322
- Testing
- high fluid intake, normal fluid intake
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Kidney Transplantation
Influence of Pioglitazone for Renal Transplant Function in Diabetics
The purpose of this study is to test whether pioglitazone is able to prevent the progression of diabetic nephropathy in kidney transplant recipients with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Kidney Transplantation, Proteinuria
- Trial name
- NCT00507494
- Testing
- pioglitazone
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Kidney Transplantation, Graft Rejection
A Study on a New Staining Method (C4d Staining) of Transplanted Kidney Biopsies
Patients who had received kidney transplantation may suffer from rejection. Recently, positive staining for C4d in kidney biopsies of malfunctioning transplant kidney is increasingly recognized as an important prognostic…
- Trial name
- NCT00498095
- Testing
- Renal biopsy
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Hospital Authority, Hong Kong
Autosomal Dominant Polycystic Kidney Disease
Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease
We aimed to evaluate the hypothalamus-pituitary-adrenal axis in autosomal dominant polycystic kidney disease (ADPKD) patients. Twenty two ADPKD patients and 27 healthy subjects were enrolled.
- Trial name
- NCT00598377
- Testing
- Tetracosactin
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Renal Cell Carcinoma
Remote Ischemia Pre-Conditioning in Patients Undergoing Partial Nephrectomy
Partial Nephrectomy has become the standard treatment in patients with tumours <7cm (T1). Even though this is a nephron sparing surgery, there is still potential for acute kidney injury, due to ischemia during the surgery.
- Trial name
- NCT01771003
- Testing
- CellAegis' autoRIC™ Device
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes Mellitus, Type 2 Diabetes With Chronic Kidney Disease
A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Compared With Placebo in Adults With Type 2 Diabetes Mellitus and Impaired Renal Function on Background Dapagliflozin
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron, compared with placebo in adults with type 2 diabetes mellitus (T2DM) and impaired renal function, who are or will be on a background…
- Trial name
- Eluminate-4 (NCT07662135)
- Testing
- Elecoglipron
- Where
- 186 sites in United States, Bulgaria and 14 more
- Volunteers
- 900 people
- Sponsor
- AstraZeneca
Vasopressin Deficiency
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs.
- Trial name
- NCT04789148
- Testing
- Intranasal Oxytocin (IN-OXT) 6 IU single dose, Intranasal Oxytocin (IN-OXT) 6 IU repeat dose, Intranasal Oxytocin (IN-OXT) 24 IU single dose
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Elizabeth Austen Lawson
Chronic Kidney Disease, Pediatric
The Cardiovascular Comorbidity in Children With Chronic Kidney Disease Study
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular (CV) morbidity and mortality. Recent studies suggest that pediatric patients with even moderately impaired kidney function may be…
- Conditions
- Chronic Kidney Disease, Pediatric, Cardiovascular Disease
- Trial name
- 4C (NCT01046448)
- Where
- 50 sites in Austria, Belgium and 13 more
- Volunteers
- 650 people
- Sponsor
- Heidelberg University
Renal Neoplasms, Localized Kidney Tumors
Effect of Non-Clamping and Sutureless Technique on Postoperative Renal Function in Robot-Assisted Partial Nephrectomy
Partial nephrectomy is an operation that removes a kidney tumor while leaving the rest of the kidney in place. It is used to treat selected patients with small tumors confined to the kidney.
- Trial name
- NCT07888608
- Testing
- Off-Clamp, Sutureless Robot-Assisted Partial Nephrectomy, Conventional Robot-Assisted Partial Nephrectomy With Artery Clamping and Sutured Reconstruction
- Where
- China
- Volunteers
- 304 people
- Sponsor
- Shao Pengfei
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