Clinical trials: Kidney Functional
Chronic Rejection of Cardiac Transplant
Everolimus and Low Dose CNI Compared With MMF and Full CNI Dose in Heart Transplanted Patients: One Year Follow up
The different mechanisms of action of Everolimus and cyclosporine suppress immune function in synergistic manner. Thus it is postulated that the use of Everolimus in combination with cyclosporine permits a significant…
- Trial name
- CRAD001AILO2 (NCT00596557)
- Testing
- everolimus
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rabin Medical Center
Uterine Fibroids, Endometriosis
Pharmacokinetics and Safety of Vilaprisan in Renal Impairment
The purpose of the study is to evaluate the pharmacokinetics of vilaprisan in subjects with moderate to severe renal impairment compared with matched subjects with normal renal function.
- Trial name
- NCT03411980
- Testing
- Vilaprisan (BAY1002670)
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Bayer
Acute Kidney Injury
The Effects of Dexmedetomidine on Postoperative Renal Function in Valvular Heart Surgery
The purpose of study is to compare the incidence of acute kidney injury in patients receiving perioperative dexmedetomidine or placebo undergoing valvular heart surgery.
- Trial name
- NCT01886079
- Testing
- dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Renal Impairment
Pharmacokinetics of Chiglitazar in Subjects With Renal Impairment and Normal Renal Function
This Phase 1 open label study is being conducted to directly characterize the pharmacokinetic (PK) profiles of Chiglitazar following administration of a single oral dose in subjects with renal impairment compared to subjects with…
- Trial name
- NCT05515458
- Testing
- Chiglitazar
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Renal Insufficiency, Kidney Diseases
Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB054707 in Participants With Normal and Impaired Renal Function and Participants on Hemodialysis
This is a multi-center, open-label, parallel-group study to evaluate oral doses of INCB054707 in participants with varying levels of renal function or impairment.
- Trial name
- NCT05624723
- Testing
- INCB054707
- Where
- 2 sites in United States, Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Incyte Corporation
PK Properties Of Gabapentin In Subjects With Impaired Renal Function
An Open Label Pharmacokinetic Study Of Gabapentin In Japanese Subjects With Renal Impairment Including Hemodialysis
To confirm the pharmacokinetics following administration of gabapentin to Japanese subjects with renal impairment, compare the results to Western study results and confirm the adaptive possibility of dose adjustment in US package…
- Trial name
- NCT00584779
- Testing
- Gabapentin
- Where
- Japan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Fluid Responsiveness in Early Post-kidney Transplantation Period
Collapsibility Index of the Inferior Vena Cava and Kidney Transplantation
Delayed graft function following renal transplantation is common occurrence and is associated with an increased risk of acute rejection and chronic allograft nephropathy.
- Trial name
- CIVC-KT (NCT06799299)
- Testing
- No Intervention
- Where
- France
- Volunteers
- 150 people
- Sponsor
- CHU de Reims
Renal Insufficiency
A Study of LY3537982 in Participants With Kidney Problems Compared With Participants With Normal Kidney Function
The purpose of this study is to help determine the right dose of LY3537982 in participants with kidney problems, particularly those with severe kidney problems. The study will last about 43 days for each participant.
- Trial name
- NCT07137689
- Testing
- LY3537982
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Renal Failure, Kidney Donors
BOne Dysfunction in Donor NEphrectomieS
Most dialysis patients die from vascular disease, which is statistically associated with changes related to chronic kidney disease associated mineral bone disorder (CKD-MBD)3-9.
- Trial name
- BONES (NCT04674397)
- Testing
- Radioisotope GFR test
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- Manchester University NHS Foundation Trust
Heart Failure, Hypertension, Pulmonary
Measurement of Endothelial Function and Cardiac Output: New Methods
The main purpose of this study is to analyse test-retest-reliability of functional quantification of endothelial dysfunction through puls-amplitude-tonometry in patients with heart failure with preserved/reduced ejection…
- Conditions
- Heart Failure, Hypertension, Pulmonary, Hypertension, Diabetic Nephropathies
- Trial name
- NCT02299960
- Testing
- Endo-PAT, NICOM
- Where
- Germany
- Volunteers
- 101 people
- Sponsor
- Charite University, Berlin, Germany
Spinal Cord Injuries, Renal Insufficiency
Sonographic Examination of Renal Function in Individuals With Long-term Spinal Cord Injury
Patients with long-term lower urinary tract dysfunction due to spinal cord injury presenting for a routine urodynamic control will be screened for inclusion and exclusion criteria.
- Trial name
- NCT04241666
- Testing
- renal scintigraphy, renal doppler sonography
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Genotype-related Drug Metabolism
Open Label Study for the Functional Characterization of Drug Metabolism and Transport
Aim of this study is to comprehensively assess in healthy volunteers the metabolic processes and factors that define drug response.
- Trial name
- IKP243 (NCT01788254)
- Testing
- Codeine, Midazolam, pravastatin
- Where
- 2 sites in Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Type 2 Diabetes
The Effects of Dapagliflozin in Normal Clinical Practice in T2D
The aim of the study is to evaluate the benefits, documented in experimental settings, of treatment with Dapagliflozin in subjects with type 2 diabetes in normal clinical practice.
- Trial name
- PRECARE (NCT05418946)
- Testing
- Dapagliflozin 10mg
- Where
- Italy
- Volunteers
- 1,400 people
- Sponsor
- University of Milan
Chronic Renal Insufficiency, Acute Renal Failure
Endotoxin, Neutrophil Function and Albumin in Renal Insufficiency
Chronic kidney disease is widespread in the western world with bacterial infection and sepsis as common complication. It has been shown that innate immune defence, represented by dysfunction of neutrophil granulocytes, is…
- Trial name
- ENARI (NCT01362569)
- Where
- Austria
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Vanessa Stadlbauer-Koellner, MD
Chronic Kidney Disease
Furosemide Stress Test as a Predictor of Tubular Function in Chronic Kidney Disease
In kidney diseases, tubule-interstitium has become much more relevant, as formerly only the glomerulus was considered to have the main importance.
- Trial name
- FST-IFTA (NCT02417883)
- Testing
- Furosemide
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Unspecified Adult Solid Tumor, Protocol Specific
LY231514 in Treating Patients With Locally Advanced or Metastatic Solid Tumors and Varying Degrees of Kidney Function
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemotherapy drugs may have different effects in patients with different degrees of kidney function.
- Trial name
- NCT00003706
- Testing
- pemetrexed disodium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
21-hydroxylase; Defect
Effects of "in UTERO" Exposure to Glucocorticoids
The main objective of this study is to show that the fetal exposure to excess of glucocorticoids is associated with a deficiency of the function beta insulin in the offspring adult.
- Trial name
- GLUCODEX (NCT01367106)
- Testing
- Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant, Complications, Renal Failure Acute Chronic
Intraoperative Assessment of Renal Tissue Oxygenation Using NIRS
The kidney is one of the most vital organs in the human body. Renal perfusion is primarily supplied by the renal artery, while the removal of metabolites and venous drainage are provided by the renal vein.
- Trial name
- NCT07409532
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Inonu University
Secondary Hypogonadism
Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function
To determine and compare the pharmacokinetics (PK) of a single dose of 25 mg Androxal in overweight male subjects with various stages of renal impairment and in volunteers with normal renal function.
- Trial name
- NCT01923857
- Testing
- Androxal 25 mg
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Worsening Chronic Heart Failure, Chronic Kidney Disease
A Study to Learn How BAY94-8862 Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body in Adult Participants With Reduced Kidney Function and in Healthy Participants With Similar Age, Weight and Gender Distribution
Researchers are looking for a better way to treat people who have worsening of chronic heart failure, a long-term condition where the heart does not pump blood as well as it should.
- Trial name
- NCT04908436
- Testing
- Finerenone (BAY94-8862)
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bayer
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