Clinical trials: Kidney Functional
Type 1 Diabetes Mellitus
Low Dose Cyclosporin and Methotrexate Therapy in Diabetes
The purpose of this study is to determine whether treatment with low dose cyclosporin and methotrexate can inhibit the development of new onset diabetes mellitus
- Trial name
- NCT00905073
- Testing
- cyclosporin and methotrexate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Georgetown University
End-Stage Renal Disease
Effects of Daily Home Hemodialysis on Circulation, Mental Functions, and Quality of Life
This study was designed to discover mechanisms responsible for the decrease in (high) blood pressure after starting daily hemodialysis, as has been observed by various investigators.
- Trial name
- NCT00150956
- Testing
- Daily home hemodialysis
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- UMC Utrecht
Kidney Transplantation, Acute Kidney Tubular Necrosis
Effect of BM-MSCs in DCD Kidney Transplantation
This study is designed to determine the efficacy and safety of allogeneic bone marrow-derived mesenchymal stem cells in kidney transplantation from Chinese donation after citizen's death (DCD).
- Trial name
- NCT02561767
- Testing
- bone marrow-derived mesenchymal stem cells, Saline, Induction therapy (ATG or Basiliximab)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Cancer
Validation of an Adjusted Dosing Algorithm of Carboplatin
An adjusted dosing algorithm for the dosing of the anticancer drug carboplatin has been developed, that accounts for high BMI, low serum creatinine values and maximal calculated renal function.
- Trial name
- NCT02103244
- Testing
- Carboplatin
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Rijnstate Hospital
Cardiac Surgery
Evaluation of Renal Function in Subjects Who Had Undergone Cardiac Surgery
To evaluate the differences between serum cystatin C based estimated glomerular filtration rate (eGFRcys), serum creatinine based eGFR (eGFRcreat) and measured glomerular filtration rate (mGFR) in subjects at high risk for acute…
- Trial name
- NCT04654221
- Testing
- mGFR by iohexol clearance
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- Quark Pharmaceuticals
Kidney Failure, Chronic
Low-frequency Electrical Muscle Stimulation vs Cycle Training During Haemodialysis
The purpose of the trial is to compare the effects of intra-dialytic low-frequency electrical muscle stimulation and intra-dialytic cycling, with usual care haemodialysis without exercise training.
- Trial name
- NCT02874521
- Testing
- Intra-dialytic LF-EMS, Intra-dialytic cycle training
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Chronic Kidney Diseases
Application of Functional Renal MRI to Improve Assessment of Chronic Kidney Disease
Research question: Can multiparametric renal Magnetic Resonance Imaging (MRI) provide structural and functional assessment of the kidneys to deliver prognostic information and guide treatment options in chronic kidney disease…
- Trial name
- AFiRM (NCT04238299)
- Testing
- Multiparametric renal MRI
- Where
- United Kingdom
- Volunteers
- 486 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Renal Impairment
Effect of Febuxostat on Renal Function in Patients With Gout and Moderate to Severe Renal Impairment
The purpose of this study is to determine the effect of febuxostat, once daily (QD) or twice daily (BID), on renal function in gout patients with elevated serum urate levels and who have moderate to severe renal impairment.
- Trial name
- NCT01082640
- Testing
- Febuxostat
- Where
- 58 sites in United States
- Volunteers
- 96 people
- Sponsor
- Takeda
Chronic Kidney Diseases, Inspiratory Muscle Training
Effects of Different Inspiratory Muscle Training Protocols in Patients With Chronic Kidney Disease
The goal of this study is to investigate the effects of different IMT protocols on respiratory muscle strength, functional exercise capacity, quadriceps femoris muscle strength (QMS), handgrip muscle strength (HGS), QoL…
- Conditions
- Chronic Kidney Diseases, Inspiratory Muscle Training, Exercise Capacity
- Trial name
- NCT06401135
- Testing
- Inspiratory muscle training
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Mustafa Kemal University
Kidney Injury Following Open-Chest Cardiac Surgery
A Phase 2b Dose Finding Study of RMC-035 in Participants Undergoing Open-chest Cardiac Surgery
The goal of this clinical trial is to identify the optimal dose of RMC-035 for protection of long-term renal function in adult patients undergoing cardiac surgery who are at high risk of kidney injury.
- Trial name
- POINTER (NCT06475274)
- Testing
- RMC-035
- Where
- 19 sites in Canada, Czechia and 2 more
- Volunteers
- 170 people
- Sponsor
- Guard Therapeutics AB
Chronic Kidney Disease
Nicotinamide Riboside Supplementation in Chronic Kidney Disease
This study is testing whether a dietary supplement called nicotinamide riboside, (NR), can be used in adults with moderate chronic kidney disease. NR is a form of vitamin B3 that may help support cellular energy metabolism.
- Trial name
- NR-CKD (NCT07693543)
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Cancer
Vegetable Garden Feasibility Trial to Promote Function in Older Cancer Survivors
Cancer survivorship has been claimed a national priority, with a call to develop effective interventions that can prevent, delay, or mitigate the adverse effects and comorbidities in this high risk population.
- Trial name
- NCT02150148
- Testing
- Experimental: Mentored Gardening Intervention
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Chronic Allograft Nephropathy
Calcineurin Inhibitor Minimisation in Renal Transplant Recipients With Stable Allograft Function
The purpose of this trial is to ascertain whether the withdrawal of calcineurin inhibitors (CNI) will lead to less kidney transplant damage when compared with minimisation.
- Trial name
- CNIM-SRT (NCT00541814)
- Testing
- Cyclosporine
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University Hospital Birmingham
Renal Artery Stenosis
Medical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis (METRAS Study)
Renal atherosclerotic stenosis (RAS) is a prevalent cause of secondary hypertension (HT). Since there are still uncertainties as to whether and in what patients revascularization by means of percutaneous renal angioplasty (PTRAS)…
- Trial name
- METRAS (NCT01208714)
- Testing
- Optimal medical therapy, revascularization
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University Hospital Padova
Renal Impairment
Pharmacokinetics and Safety of ALKS 5461 in Subjects With Renal Impairment and Normal Renal Function
This study will evaluate the effect of various degrees of renal function on the pharmacokinetics and safety of ALKS 5461.
- Trial name
- NCT02508506
- Testing
- ALKS 5461
- Where
- 3 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Acute Kidney Injury
Safety and Efficiency Study of Loading Dose Atorvastatin in Cardiac Surgery
Statins were reported to have pleiotropic effects including antiinflammatory, anti-oxidative stress effects and stabilise plaque in some conditions.
- Trial name
- NCT01547455
- Testing
- Atorvastatin(Lipitor)
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College
Kidney Failure, Chronic
Pharmacokinetics, Pharmacodynamics, and Safety Study of Ticagrelor in Hemodialysis Patients and Healthy Subjects
A phase I, open-label study comparing the pharmacokinetics, pharmacodynamics, safety and tolerability of ticagrelor in hemodialysis patients to healthy subjects with normal renal function.
- Trial name
- NCT02022748
- Testing
- ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Kidney Scarring
Detection of Renal Fibrosis and Prediction of Kidney Function Decline
This study will investigate the ability of renal MRI to detect fibrosis, how this correlates to renal function and how well renal MRI biomarkers can predict decline in kidney function over time.
- Trial name
- MARS (NCT04625140)
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Kidney Diseases, Obesity
Epidemiologic Data of Patients in a Teaching Hospital
This small cross-sectional epidemiological study is designed to evaluate the prevalence of the following parameters in hospitalized patients in a tertiary teaching hospital (medical department only): kidney insufficiency obesity…
- Trial name
- NCT00114335
- Where
- Switzerland
- Volunteers
- 352 people
- Sponsor
- Luzerner Kantonsspital
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