Clinical trials: Kidney Injury
Acute Kidney Injury
Impact of a Treatment With Angiotensin Receptor Blocker on Outcome After Acute Kidney Injury in Patients Discharged From the ICU.
The patients discharged from intensive care units (ICU) have a high incidence of cardiovascular events and mortality rate during the year following ICU discharge.
- Trial name
- START-or-NOT (NCT05272878)
- Testing
- IRBESARTAN, tablet, 150 mg
- Where
- France
- Volunteers
- 508 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Kidney Injury
Efficacy Study of a Selective Cytopheretic Device (SCD) in Patients With Acute Kidney Injury
The purpose of this protocol is to evaluate the safety of a selective cytopheretic device (SCD) in patients that are on continuous renal replacement therapy (CRRT) for acute kidney injury (AKI).
- Trial name
- NCT01400893
- Testing
- SCD
- Where
- 26 sites in United States
- Volunteers
- 134 people
- Sponsor
- SeaStar Medical
Bacterial Infections
Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLED
Colistin was developed in the 1960s and preliminary pharmacokinetic studies were performed at that time. Dosing recommendations, on the basis of these pharmacokinetic studies, are listed in the drug's product information.
- Trial name
- NCT05586438
- Testing
- Colistin Sulfomethate
- Where
- Thailand
- Volunteers
- 13 people
- Sponsor
- Mahidol University
Acute Kidney Disease, Acute Kidney Injury
Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction
KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill.
- Trial name
- KARMA (NCT07052617)
- Testing
- Continuos renal replacement therapy
- Volunteers
- 2,500 people
- Sponsor
- Croatian Society for Organ Support
Liver Cancer, Adult
Risk Stratification and Proactive Nursing Intervention for Acute Kidney Injury Following Interventional Therapy in Patients With Liver Cancer
This study focuses on the early identification and precision prevention of acute kidney injury (AKI) following interventional therapy in patients with liver cancer.
- Trial name
- NCT07681817
- Testing
- Risk-stratified active nursing intervention group, Standard care (usual post-interventional nursing care)
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Kidney Diseases, Kidney Injury
Study of MB-102 (Relmapirazin) and the Use of the MediBeacon® Transdermal GFR Measurement System Using the TGFR Reusable Sensor With Disposable Adhesive Ring
The goal of this clinical trial was to compare transdermal glomerular filtration rate (tGFR) to plasma-derived indexed GFR (nGFR) using MB-102 (relmapirazin) as the fluorescent compound.
- Conditions
- Kidney Diseases, Kidney Injury, Kidney Failure
- Trial name
- NCT05777174
- Testing
- MB-102, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- 5 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Kidney Injury, Acute
Inorganic Nitrate (NaNO3) Prevention of Contrast-Associated Acute Kidney Injury
This pilot study is designed to test the logistics and recruitment of a trial testing the benefit of sodium nitrate in the prevention of contrast-associated kidney injury in a group of patients at high-risk.
- Trial name
- NCT07016074
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Critical Care, Intensive Care, Fluid Accumulation
CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS
This study is enrolling adult patients who require a prolonged stay in the intensive care unit (ICU). These patients often receive large amounts of intravenous fluids, which can contain more salt (sodium and chloride) than the…
- Conditions
- Critical Care, Intensive Care, Fluid Accumulation, Fluid and Electrolyte Imbalance, Critical Illness
- Trial name
- CRUSADERS (NCT07189091)
- Testing
- Glucose 5% for fluid creep, NaCl 0.9% (normal saline) for fluid creep, PlasmaLyte as maintenance fluid
- Where
- 4 sites in Belgium
- Volunteers
- 640 people
- Sponsor
- University Hospital, Antwerp
Acute Kidney Injury, Children
Renal Oxygen Saturation and Its Association With Acute Renal Injury
Peri-operative renal dysfunction is a major mortality and morbidity cause following cardiac and major vascular surgery. Although several intra-operative strategies are proposed for better outcomes, no effective and fast resulting…
- Conditions
- Acute Kidney Injury, Children, Cardiac Surgery
- Trial name
- NCT03608956
- Where
- Turkey (Türkiye)
- Sponsor
- Marmara University
Acute Kidney Injury, Metabolic Acidosis
Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury
The study investigates whether sodium bicarbonate is able to reduce the occurrence of major adverse kidney events on day 90 (MAKE90) in critically ill patients with metabolic acidosis and acute kidney injury (AKI).
- Conditions
- Acute Kidney Injury, Metabolic Acidosis, Critical Illness
- Trial name
- ESCALATE (NCT07464431)
- Testing
- Sodium Bicarbonate 8.4% Solution for Injection, Balanced crystalloid solution
- Where
- Germany
- Volunteers
- 660 people
- Sponsor
- Universität Münster
AKI, ICU
What Are the Predictors of Acute Kidney Injury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University Children Hospital?
Identify the Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year
- Trial name
- NCT07517939
- Testing
- Clinical and laboratory assessment
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury
Continuous Venovenous Hemodiafiltration Versus Sustained Low-efficiency Hemodialysis for Critically Ill Patients With Acute Kidney Injury in Intensive Care Unit
The investigators conducted a comparison trial between SLED and CRRT in critically ill patients to evaluate the outcome for all cause mortality at 30 day .
- Trial name
- NCT02879201
- Testing
- Slow efficiency dialysis
- Where
- Thailand
- Volunteers
- 27 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Cirrhosis, Liver, AKI
Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
A pilot study of Dextran-40 infusion in patients with decompensated cirrhosis presenting with AKI
- Trial name
- NCT03070353
- Testing
- Dextran 40
- Volunteers
- 10 people
- Sponsor
- Ramathibodi Hospital
Solid Tumors, Cisplatin Nephrotoxicity
Protecting the Kidney's Proximal Tubules From Platinum-Based Chemotherapy Toxicity
Patients with cancer who receive platinum-based chemotherapy are at increased risk of kidney injury caused by these drugs. This form of toxicity can lead to treatment delays, dose reductions, or permanent discontinuation of…
- Trial name
- DAPA-ARMOR (NCT07018622)
- Testing
- Dapagliflozin 10 MG Oral Tablet
- Where
- Mexico
- Volunteers
- 46 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Cirrhosis, End Stage Liver Disease
Mild Hypothermia and Acute Kidney Injury in Liver Transplantation
Acute kidney injury (AKI), or worsening kidney function, is a common complication after liver transplantation (20-90% in published studies).
- Conditions
- Cirrhosis, End Stage Liver Disease, Acute Kidney Injury, Liver Transplant; Complications
- Trial name
- MHALT (NCT03534141)
- Testing
- Esophageal cooling/warming device, Mild hypothermia, Normothermia
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Acute Kidney Injury
The AminoECMO Pilot Trial
Acute kidney injury (AKI) is a serious problem for patients in intensive care, especially those on life-support machines like ECMO (which helps the heart and lungs).
- Trial name
- AminoECMO (NCT07438262)
- Testing
- Synthamin-17 (10% amino acid solution)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Chronic Kidney Disease
Efficacy Trial of N-Acetylcysteine and Sodium Bicarbonate for the Prevention of Contrast-Induced Acute Kidney Injury
Contrast-Induced Acute Kidney Injury(CIAKI) was defined as an absolute increase in serum creatinine of more than or equal to 0.3mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine of more than or equal to 50%…
- Trial name
- PREKIT (NCT01210456)
- Testing
- Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate
- Where
- Japan
- Volunteers
- 458 people
- Sponsor
- Tokushukai Medical Group
Kidney Failure, Acute
Preventing Acute Renal Failure After Cardiac Surgery in High Risk Patients Using Sodium Bicarbonate Therapy
The purpose of this study is to determine whether sodium bicarbonate is effective in reducing kidney injury that may occur during cardiac surgery.
- Trial name
- PARACHUTE (NCT00522756)
- Testing
- Sodium bicarbonate, Sodium chloride
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Kidney Injury, Liver Transplant; Complications
Effect of Terlipressin on the Incidence of Early Postoperative Acute Kidney Injury in Liver Transplantation Patients
The goal of this clinical trial is to evaluate the effect of intraoperative terlipressin on the incidence of early postoperative acute kidney injury in deceased doner liver transplantation.
- Trial name
- NCT06108362
- Testing
- Terlipressin, normal saline
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Renal Artery Stenosis, Ischemic Nephropathy
Hypoxia and Inflammatory Injury in Human Renovascular Hypertension
Current treatments for ARAS based on restoring blood flow alone have been unsuccessful at recovering kidney function. For this reason we are studying a stem cell product called "mesenchymal stem cells" or MSC.
- Conditions
- Renal Artery Stenosis, Ischemic Nephropathy, Renovascular Disease, Chronic Kidney Disease
- Trial name
- NCT02266394
- Testing
- Mesenchymal stem cell, Mesenchymal stem cell delivery with stent placement
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic