Clinical trials: Kidney Insufficiency
Chronic Rejection, Kidney Insufficiency
Rituximab Treatment to Block HLA Antibodies in Renal Transplant Recipients
The purpose of this study is to determine if administration of rituximab blocks the development of donor specific antibodies (DSA) in transplant recipients who have developed renal dysfunction and DSA after renal transplant.
- Trial name
- NCT00261547
- Testing
- Rituximab
- Sponsor
- Massachusetts General Hospital
ESRD
Assessment of Gonadal Functions in Uremic Male Patients
1. Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) . 2. Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin…
- Trial name
- NCT04710238
- Volunteers
- 100 people
- Sponsor
- Assiut University
Human Immunodeficiency Viruses, Kidney Failure
Impact of Drug Therapy and Co-Morbidities on the Development of Renal Impairment in HIV-Infected Patients
Tenofovir (TDF)-containing regimens may be associated with decreasing renal function in HIV-infected patients concurrently treated with boosted PI's and/or have co-morbid conditions including diabetes mellitus, hypertension…
- Conditions
- Human Immunodeficiency Viruses, Kidney Failure, HIV Infections
- Trial name
- NCT00551655
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- AIDS Arms Inc.
Chronic Kidney Disease
Supplemented Very Low Protein Diet and the Progression of Chronic Kidney Disease
This is a prospective single center randomized controlled trial with a total duration of 18 months aiming to evaluate the effectiveness and the safety of a very low protein diet supplemented with ketoanalogues of essential…
- Trial name
- KETOPROG (NCT02031224)
- Testing
- Conventional low protein diet, Very low protein diet supplemented with Ketosteril
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Anemia Working Group Romania
Rhabdomyolysis, Acute Kidney Injury
Use of a Vacuum Mattress During Laparoscopic Sleeve Gastrectomy to Reduce the Concentration of Rhabdomyolysis Markers and Acute Renal Failure
This prospective clinical trial aimed to assess the usefulness of the usage of a vacuum mattress during laparoscopic sleeve gastrectomy (LSG) in the reduction of levels of rhabdomyolysis markers (myoglobin, creatine kinase…
- Conditions
- Rhabdomyolysis, Acute Kidney Injury, Bariatric Surgery Candidate
- Trial name
- NCT06338423
- Testing
- vacuum mattress, Standard Mattress
- Where
- Poland
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Cirrhosis, Liver, Acute Kidney Injury
Initial Resuscitation for Acute Kidney Injury in Cirrhosis
The goal of this interventional study is to evaluate two strategies for how to provide intravenous (IV) fluids for treating patients with acute kidney injury (AKI) in cirrhosis.
- Conditions
- Cirrhosis, Liver, Acute Kidney Injury, Hepatorenal Syndrome
- Trial name
- RAKI-VAGA (NCT06525623)
- Testing
- Recommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease Stage 3 and 4
Safety and Efficacy of Paricalcitol Capsules in Decreasing Serum Parathyroid Hormone Levels in Children Aged 10-16 With Chronic Kidney Disease (CKD)
Part 1: To determine the safety, tolerability, and pharmacokinetics of a single dose of 3 μg paricalcitol capsules in children ages 10 to 16 years with moderate to severe chronic kidney disease (CKD Stages 3 and 4).
- Trial name
- NCT01020487
- Testing
- Paricalcitol
- Volunteers
- 47 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Arterio-Venous Fistula, ESRD
VasQ External Support for Arteriovenous Fistula
This is a prospective clinical study of the VasQ external support for arteriovenous fistulas. The device is designed to improve fistula outcomes by optimizing the geometrical configuration of the fistula, influencing…
- Conditions
- Arterio-Venous Fistula, ESRD, Steal Syndrome, Aneurysm
- Trial name
- NCT03242343
- Testing
- VasQ
- Where
- 15 sites in United States
- Volunteers
- 144 people
- Sponsor
- Laminate Medical Technologies
Kidney Failure, Chronic
Dietary Maneuvers to Reduce Production of Colon-Derived Uremic Solutes
This study will assess whether dietary fiber supplements can reduce the production of chemicals which are produced by colon bacteria and normally excreted from the body by the kidney, but build up in the body in patients on…
- Trial name
- NCT01186276
- Testing
- Fiber, Corn starch
- Where
- 3 sites in United States
- Volunteers
- 58 people
- Sponsor
- Stanford University
Kidney Function Decline, Chronic Kidney Disease
Comprehensive Kidney Function Assessment and Early Warning in Older Adults
This completed observational cohort study evaluates a comprehensive set of clinical and molecular markers of kidney function in two established cohorts of Chinese adults aged 60 years or older.
- Conditions
- Kidney Function Decline, Chronic Kidney Disease, Kidney Failure
- Trial name
- NCT07765134
- Where
- China
- Volunteers
- 5,588 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Renal Insufficiency, Chronic
Safety and Efficacy of Zemplar Capsule in Reducing Serum iPTH Levels in Chronic Kidney Disease Subjects (Daily Dosing)
The objective of this study is to determine whether paricalcitol is safe and effective compared to placebo in reducing elevated serum PTH levels in patients with chronic kidney disease.
- Trial name
- NCT00048516
- Testing
- paricalcitol capsule
- Where
- 18 sites in United States, Poland
- Volunteers
- 68 people
- Sponsor
- Abbott
Acute Kidney Injury, Critical Illness Myopathy
Critical Illness Myopathy and Trajectory of Recovery in AKI Requiring CRRT
The purpose of this study is to determine whether patients with acute kidney injury requiring renal replacement therapy have a higher incidence of muscle wasting than controls and whether the course of recovery is longer compared…
- Conditions
- Acute Kidney Injury, Critical Illness Myopathy, Dialysis; Complications
- Trial name
- NCT05287204
- Testing
- Musculoskeletal ultrasound, Assessments of muscle strength and physical function, Metabolomics
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Iowa
Red-Cell Aplasia, Pure, Renal Insufficiency, Chronic
Pure Red Cell Aplasia in Patients With Chronic Kidney Disease and in Use of Epoetin Alfa
The purpose of this study is to determine occurrence of pure red cell aplasia in a group of participants with chronic renal insufficiency and with resistance criteria to epoetin alfa treatment.The investigational product is…
- Trial name
- NCT02648126
- Testing
- Pure Red Cell Aplasia diagnostic confirmation
- Volunteers
- 531 people
- Sponsor
- The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz)
Disorder Related to Renal Transplantation, Chronic Kidney Disease
Contribution of Renal Function to Endothelial Dysfunction in Living Kidney Donors and Transplant Recipients
Endothelial dysfunction one-year after transplantation mainly depends on transplant-associated factors and only marginally on reduced renal function.
- Conditions
- Disorder Related to Renal Transplantation, Chronic Kidney Disease, Endothelial Dysfunction
- Trial name
- CONFUCIUS (NCT02515643)
- Testing
- Endothelial dysfunction
- Where
- 4 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Heart Failure
VExUS in Patients With Acute Heart Failure
The importance of assessing venous congestion in heart failure patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool.
- Trial name
- NCT06397404
- Testing
- Venous excess ultrasound score (VExUS) protocol
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Sickle Cell Disease (SCD)
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease
The goal of the study was to evaluate descriptively the effect of crizanlizumab + standard of care and standard of care alone on renal function in sickle cell disease patients ≥ 16 years with chronic kidney disease due to sickle…
- Trial name
- STEADFAST (NCT04053764)
- Testing
- Crizanlizuamb, Standard of Care
- Where
- 24 sites in United States, Brazil and 9 more
- Volunteers
- 58 people
- Sponsor
- Novartis Pharmaceuticals
Acute Kidney Injury, Hypoalbuminemia
Predicting Worsening Acute Kidney Injury With a Water-Pill (Furosemide) Test and Blood Markers in Patients With Low Albumin
The goal of this clinical trial is to learn if serum biomarkers can better predict worsening of acute kidney injury (AKI) compared to the Furosemide Stress Test (FST) in adult patients with low albumin levels (hypoalbuminemia)…
- Trial name
- NCT07688733
- Testing
- Furosemide Stress Test, Serum Biomarkers and NGAL
- Where
- Mexico
- Volunteers
- 55 people
- Sponsor
- Maithe Caroline Inacio
Renal Insufficiency Chronic
A Trial of Hydroxynidone Capsules in Single-dose Administration for Patients With Renal Insufficiency
Hydronidone capsules are pyridinone-based small molecule compounds. Hydronidone has not been approved for commercial sale both domestically and internationally.
- Trial name
- NCT07262333
- Testing
- Hydronidone capsules
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Renal Failure, Anesthesia
Renal Function During Pediatric Anesthesia
It is known that volatile anesthesia, such as sevoflurane, retain water and that this appears more pronounced in children. However, the mechanisms for this effect is unknown and it is not clear if the commonly used anesthetic…
- Trial name
- NCT02571426
- Testing
- Sevoflurane, propofol
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Acute Kidney Injury, Hypothermia
Hypothermia Risk With Continuous Renal Replacement Therapy
The present study aims at testing if the TherMax blood warmer is more accurate and reliable in reaching and maintaining chosen target temperature during continuous renal replacement therapy as compared to the Prismaflo IIS blood…
- Trial name
- HR-CRRT (NCT03973814)
- Testing
- Thermax Blood Warmer
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
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