Clinical trials: Kidney Insufficiency
Chronic Kidney Diseases
Core Outcome Set for Pharmacist-led Interventions in CKD
Background Chronic kidney disease (CKD) is a progressive condition characterised by a gradual reduction in kidney function and structure over time.
- Trial name
- COSP-KD (NCT05987280)
- Testing
- eDelphi method
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Neoplasms, Kidney Failure
Post-transplant Cancer Incidence and Survival in Patients With or Without Pre-transplant Cancer
Patients with previous malignancies have increasingly been accepted for renal transplantation. However, post-transplant malignancy risk and survival rates of these patients are unknown.
- Trial name
- NCT02491580
- Where
- Sweden
- Volunteers
- 2,370 people
- Sponsor
- Uppsala University
Acute Kidney Injury
Systemic Metabolic Contribution From Continuous Renal Replacement Therapy (CRRT)
The purpose of this observational study is to measure the number of calories delivered from fluids used in continuous renal replacement therapy (CRRT).
- Trial name
- NCT02998346
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Renal Failure
Randomized Fistula Study
The primary objective of this study is to compare two treatment strategies for establishing dialysis access in patients with unsuitable forearm veins for the standard forearm primary radio-cephalic arteriovenous fistula also…
- Trial name
- NCT00808561
- Testing
- Group 1: Alternative Fistula, Group 2: Forearm AV Graft
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Heart Failure, Chronic Kidney Diseases
DKK3 for Prognosis and Monitoring of GFR Decline in Heart Failure
The individual course of chronic kidney disease (CKD) may vary, and improved methods for identifying which patients will experience estimated glomerular filtration rate (eGFR) decline are needed.
- Trial name
- NCT04111094
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 290 people
- Sponsor
- University of Giessen
Chronic Kidney Disease, Chronic Kidney Disease Requiring Chronic Dialysis
Breaking Down Care Process and Patient-level Barriers to Arteriovenous Access Creation Prior to Hemodialysis Initiation
More than 80% of individuals in the U.S. start maintenance hemodialysis (HD) with a central venous catheter, despite substantial evidence that starting HD with an arteriovenous (AV) access improves quality of life, lowers…
- Trial name
- NCT04032613
- Testing
- Vascular Access Navigation and Education Quality Improvement Program
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus Type 2 With Proteinuria, Diabetes Mellitus, Type 2
Treatment Optimization for Patients With Type 2 Diabetes Using Empagliflozin and Finerenone in a Remote Clinical Trial
The goal of this clinical trial is to determine the feasibility of remote clinical trial conduct in patients with type 2 diabetes and elevated albuminuria.
- Conditions
- Diabetes Mellitus Type 2 With Proteinuria, Diabetes Mellitus, Type 2, Diabetes Mellitus, Diabetes
- Trial name
- Optimize@Home (NCT06094920)
- Testing
- Empagliflozin 10 MG, Finerenone, Withings BPM Connect
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Chronic Kidney Disease
Sleep Disturbances as a Risk Factor in Chronic Kidney Disease
This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.
- Trial name
- CRIC (NCT00817427)
- Testing
- Controls Short sleep, CKD- sleep extension
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Acute Kidney Injury
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial…
- Trial name
- NCT07718373
- Testing
- L-arginine
- Volunteers
- 5,000 people
- Sponsor
- Xijing Hospital
End Stage Renal Disease
24 Hour Use of the Wearable Artificial Kidney
This is a prospective, interventional study designed to provide preliminary data on the human use of the WAK. Up to 10 subjects currently receiving intermittent hemodialysis (HD) treatment three times per week for end-stage renal…
- Trial name
- WAK US 1 (NCT02280005)
- Testing
- WAK Treatment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Blood Purification Technologies, Inc.
Growth Hormone Deficiency, Turner Syndrome
Evaluation of Convenience and Compliance of the Easypod™ Electronic Self-injector
This is an international, multicenter study involving children treated with Saizen®, a growth hormone, who will be trained to use easypod, a new electronic injector and will complete a questionnaire after 12 week of use.
- Conditions
- Growth Hormone Deficiency, Turner Syndrome, Chronic Renal Failure, Small for Gestational Age
- Trial name
- NCT00738205
- Volunteers
- 834 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Chronic Kidney Disease
Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
The primary objective is to determine whether reduction of serum calcium concentration by cinacalcet leads to reduction of mean blood pressure adjusted c-fPWV.
- Trial name
- ECIRA (NCT01250405)
- Testing
- Cinacalcet
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Laval University
Kidney Disease, Renal Insufficiency Chronic
A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function
The purpose of the study is to assess the amount of Eloralintide (LY3841136) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment and to…
- Conditions
- Kidney Disease, Renal Insufficiency Chronic, Kidney Failure, Chronic, Renal Impairment
- Trial name
- NCT07426380
- Testing
- LY3841136
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Acute Renal Failure
Vasodilators and Anti-Oxidant Therapy in Early ATN
Patients developing kidney failure after open heart surgery experience an abrupt decrease in blood flow to the kidney. The investigators hypothesize that administration of fenoldopam mesylate (a drug that increases blood flow to…
- Trial name
- NCT00286403
- Testing
- Fenoldopam Mesylate and/or MESNA
- Where
- 2 sites in United States
- Sponsor
- Southeast Renal Research Institute
End-stage Renal Disease (ESRD), Peritoneal Dialysis (PD)
Amino Acid (15) Peritoneal Dialysis Solution for Nutritional Improvement in Peritoneal Dialysis Patients
The goal of this clinical trial is to assess whether Amino Acid (15) Peritoneal Dialysis Solution can improve the nutritional status of adults with end-stage kidney disease who have received peritoneal dialysis for 6 months or…
- Conditions
- End-stage Renal Disease (ESRD), Peritoneal Dialysis (PD), Nutritional Status, Renal Replacement Therapy
- Trial name
- AA15-PD-Nut-SH (NCT07370441)
- Testing
- amino acid (15) peritoneal dialysis solution
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai 10th People's Hospital
End-Stage Kidney Disease, End Stage Renal Disease (ESRD)
Dialysis Efficiency and Transporter Evaluation Computational Tool in Peritoneal Dialysis
The goal of this prospective diagnostic test (correlation) study is to develop and investigate the performance of artificial intelligence in predicting peritoneum transporter status and dialysis efficiency in adult patients…
- Conditions
- End-Stage Kidney Disease, End Stage Renal Disease (ESRD), End Stage Renal Disease on Dialysis (Diagnosis), End Stage Renal Failure on Dialysis
- Trial name
- DETECT-PD (NCT06842927)
- Testing
- data collection, data report
- Where
- Hong Kong
- Volunteers
- 350 people
- Sponsor
- Tuen Mun Hospital
Acute Kidney Injury
PK and PD of Sequential Multiple Ascending, Repeat Doses of Oral CXA-10 in Healthy Obese Male Subjects
The main purpose of this trial is to demonstrate the safety, tolerability and pharmacokinetics (PK) of CXA-10 and its metabolite(s) administered as multiple ascending oral doses over 14 days to healthy obese male volunteers.
- Trial name
- NCT02460146
- Testing
- CXA-10
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Complexa, Inc.
Chronic Disease, Chronic Diseases in Adolescence
Home-based Aerobic Training Among Adolescents With Chronic Diseases During COVID-19 Pandemic
Data show that the coronavirus disease 2019 (COVID-19) symptoms can be severe in 4% and 3% of the adolescents aged 11-15 years and ≥ 16 years, respectively.
- Conditions
- Chronic Disease, Chronic Diseases in Adolescence, Chronic Disease of Immune System, Chronic Kidney Diseases
- Trial name
- NCT04458246
- Testing
- Exercise training group
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- University of Sao Paulo
End Stage Renal Disease (ESRD), Maintenance Hemodialysis
Impact of APP-assisted Patient Management on the Quality Control of Blood Purification Therapy
Many maintenance hemodialysis (MHD) patients develop negative outlooks due to their illnesses and complications, making their quality of life and prognosis a clinical concern.
- Trial name
- NCT07291154
- Testing
- APP-based management
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Yunfeng Xia
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