Clinical trials: Kidney Insufficiency
Kidney Failure, Chronic
Patient-Provider Trust Among Individuals With End-Stage Kidney Disease
This study will examine communication and trust between patients in the kidney transplant process and their health care providers.
- Trial name
- NCT00075036
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Renal Dialysis, Hemodiafiltration
Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients undergoing hemodialysis, largely due to structural cardiac changes associated with left ventricular diastolic dysfunction.
- Conditions
- Renal Dialysis, Hemodiafiltration, Diastolic Dysfunction, Kidney Failure
- Trial name
- EXE-HDF (NCT06584734)
- Testing
- Not exercise, Exercise during hemodiafiltration session
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Acute Kidney Injury, Hemolysis
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery.
- Conditions
- Acute Kidney Injury, Hemolysis, Thrombocytopenia, Surgery
- Trial name
- NCT06349577
- Testing
- Non-pulsatile blood flow, Pulsatile blood flow
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Colorado, Denver
Diabetic Kidney Disease, Diabetes Type 2
Biorepository of Biospecimen Samples in Matched Healthy Control Participants and Participants Diagnosed With Diabetic Kidney Disease, Chronic Kidney Disease, or Type 2 Diabetes
The Investigators will generate a repository of human biosamples across therapeutic areas that will be used to identify disease-associated biomarkers and potential targets with immune and multi-omics profiling.
- Conditions
- Diabetic Kidney Disease, Diabetes Type 2, Chronic Kidney Diseases, Healthy
- Trial name
- SAN-08961 (NCT05631119)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sanguine Biosciences
Chronic Kidney Diseases
Skeletal Muscle Oxygenation in Patients With Chronic Kidney Disease Stage 2, 3 and 4
Endothelial dysfunction occurs early in chronic kidney disease (CKD) and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality.
- Trial name
- NCT05250167
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Kidney Diseases, Genetic Predisposition
APOL1 Genetic Testing Program for Living Donors, Part 2
Living donor (LD) kidney transplantation is the optimal treatment for patients with end-stage kidney disease (ESKD). However, LDs take on a higher risk of future ESKD themselves.
- Trial name
- NCT04999436
- Testing
- APOL1 Counseling Training Program
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Northwestern University
Staphylococcus Aureus
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis…
- Trial name
- PEAK (NCT06749457)
- Testing
- AZD7760
- Where
- 40 sites in United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy, Renal Insufficiency
A Single-Dose, Pharmacokinetic/Pharmacodynamic (PK/PD), & Safety Study of BIIB017 in Participants With Renal Impairment & Healthy Volunteers
The primary objective of the study is to evaluate the pharmacokinetics (PK) of a single dose of PEGylated Interferon Beta-1a (BIIB017) administered subcutaneous in participants with renal impairment and in participants with…
- Trial name
- NCT01119781
- Testing
- BIIB017(peginterferon beta-1a)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Biogen
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival.
- Trial name
- NCT04103307
- Testing
- Dialysis cooling
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Diseases
Prevalance Of Helicobacter Pylori Infection In Chonic Kidney Diseased Patient Admitted To Luxor Medical Complex
Detect prevalence of Helicobacter pylori infection in chronic kidney diseased patient admitted to Luxor medical complex and possible role of Helicobacter pylori in pathogenesis of chronic kidney diseased patient of unknown…
- Trial name
- NCT06371001
- Testing
- disease
- Volunteers
- 122 people
- Sponsor
- Assiut University
Chronic Kidney Disease
Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the MediBeacon Transdermal GFR Measurement System in Evaluation of Kidney Function in Normal and Renal Compromised Subjects
The goal of this clinical trial was to compare transdermal glomerular filtration rate (tGFR) to plasma-derived indexed (to body surface area; BSA) GFR (nGFR) using MB-102 (relmapirazin) as the fluorescent compound.
- Trial name
- NCT05425719
- Testing
- MB-102, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- 8 sites in United States, China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
End-Stage Renal Disease, Diabetes Mellitus
Pilot: Insulin Sensitivity/Management in Hyperglycemic Patients in Perioperative Period ESRD/Non-ESRD
This study is for people with diabetes who have either healthy kidneys or who have end stage renal disease (ESRD) and are on hemodialysis that are having surgery.
- Trial name
- NCT03526536
- Testing
- IV Novolin R human insulin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Downstate Medical Center
Heart Failure, Kidney Failure
Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal Impairment
The main purpose of this study is to examine the effect of add-on therapy with the direct renin inhibitor Aliskiren in comparison to placebo on renal blood flow in patients with heart failure and reduced renal function.
- Trial name
- ARIANA-CHF-RD (NCT00881439)
- Testing
- Aliskiren
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Chronic Kidney Disease
Warfarin Versus Aspirin in Patients With Atrial Fibrillation and Chronic Kidney Disease
In this study, the investigators examine whether aspirin or warfarin is useful for atrial fibrillation patients with chronic kidney disease.
- Trial name
- NCT01668901
- Testing
- warfarin, Aspirin
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Fluid Balance, Acute Kidney Injury
Fluid Balance in Acute Kidney Injury in Critically Ill Patients
This prospective observational cohort study evaluates if fluid balance in the first 48 hours of ICU admission is linked to acute kidney injury (AKI) in critically ill adults.
- Conditions
- Fluid Balance, Acute Kidney Injury, Critically Ill Acute Kidney Injury, Critically Ill
- Trial name
- NCT07338734
- Volunteers
- 120 people
- Sponsor
- Assiut University
Acute Kidney Injury
Carotid Doppler and IVC Measurements for Volume Guided Management in Acute Kidney Injury Patients
1. Evaluate Inferior Vena Cava Indices (Diameters , IVC-CI)\&carotid doppler measurements (corrected Carotid Flow Time ,Carotid Blood Flow ,Carotid Artery Peak Velocity Variations) as Non-Invasive Technique for volume guided…
- Trial name
- NCT05938049
- Testing
- IVC ultrasound & Carotid doppler
- Volunteers
- 60 people
- Sponsor
- Assiut University
Hyperphosphatemia, End-stage Renal Disease
Study of Individualized Therapy on Hyperphosphatemia in Maintenance Hemodialysis Patients
This study is designed to study and compare the efficacy and cost-effectiveness of individualized phosphate-lowering therapy in comparison with regular guideline-recommended therapy.
- Trial name
- NCT02684643
- Testing
- enhanced individualised therapy, non-enhanced individualised therapy, regular intervention
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Huashan Hospital
Chronic Kidney Diseases, Chronic Kidney Disease stage3
Effects of Brazil Nut Supplementation in Patients With Chronic Kidney Disease Undergoing Conservative Treatment
The aim of this study is to evaluate the effects of Brazil nut supplementation on inflammation, oxidative stress and intestinal microbiota in patients with chronic kidney disease undergoing conservative treatment.
- Conditions
- Chronic Kidney Diseases, Chronic Kidney Disease stage3, Chronic Kidney Disease Stage 3A, Chronic Kidney Disease Stage 3B
- Trial name
- NCT06394544
- Testing
- Brazil Nut
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal Fluminense
Diabetes Mellitus, Chronic Kidney Diseases
American Indian Chronic Renal Insufficiency Cohort Study (AI-CRIC Study)
Despite many advances in our understanding of the natural history and progression of chronic kidney disease (CKD) and cardio vascular disease (CVD) in the parent CRIC study over the past 15 years, important questions about key…
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Heart Diseases, Cardiovascular Diseases
- Trial name
- AI-CRIC (NCT04185844)
- Where
- 3 sites in United States
- Volunteers
- 504 people
- Sponsor
- University of New Mexico
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