Clinical trials: Kidney Insufficiency
Systemic Lupus Erythematosus (Sle), Primary Ovarian Insufficiency (Poi)
Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires
Background: Systemic lupus erythematosus (SLE) is a disease that affects females nine times more often than males. People with SLE are often treated with cyclophosphamide (CYC).
- Trial name
- NCT05567198
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
End-Stage Kidney Disease, Hemodialysis
A Prospective, Multi-center Registry to Evaluate Safety and Efficacy of Hativ® ELectrocardiogram Monitoring on Patients with Hemodialysis
The high mortality rate and costs of patients with end-stage renal disease (ESRD) are a medical and socio-economic burden, so managing their risk factors is very important.
- Trial name
- NCT06688565
- Testing
- Hativ® electrocardiogram monitoring
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Hallym University Medical Center
Renal Impairment
Study to Assess the Pharmacokinetics and Safety of AZD9977 in Participants With Renal Impairment
This is a single dose, non-randomized, open-label, parallel group study. The study will be conducted in participants with severe renal impairment and compared with matched participants with normal renal function.
- Trial name
- NCT04469907
- Testing
- AZD9977
- Where
- 6 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Kidney Disease
Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients
The majority of individuals with advanced ESRD have reduced exercise capacity in part due to decreased muscle mass. This leads to a reduced ability to perform daily activities, a greater incidence of falls, and a reduced quality…
- Trial name
- PERFECT (NCT01990495)
- Testing
- Exercise training, Usual Care
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- VA Office of Research and Development
Normal Renal Function, Impaired Renal Function
Evaluation of Renal Function Impairment on the Pharmacokinetics of LEE011
The purpose of this study is to characterize the PK and safety profile of LEE011 following a single oral dose in adult subjects with various degrees of renal impairment compared to a matched group of healthy subjects with normal…
- Trial name
- NCT02431481
- Testing
- LEE011
- Where
- 4 sites in United States, Bulgaria and 2 more
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Chronic Kidney Diseases
The Effectiveness and Safety of Calcium Carbonate in Chronic Kidney Disease With Normophosphatemia
Background: Patient with stage 3 or 4 chronic kidney disease (CKD) usually has normal level of serum phosphate, due to increased serum fibroblast growth factor-23 (FGF23) level that resulted in increased phosphate urine…
- Trial name
- NCT03550534
- Testing
- Calcium Carbonate
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Universitas Indonesia
End-Stage Kidney Disease
Adding Receptive Music to Intradialytic Resistance Exercise in Adults Receiving Maintenance Hemodialysis
People receiving maintenance hemodialysis commonly experience reduced physical function and exercise capacity. Intradialytic resistance exercise may help preserve or improve physical function, while receptive music listening may…
- Trial name
- NCT07819331
- Testing
- Intradialytic Resistance Exercise, Receptive Music Listening
- Where
- Tunisia
- Volunteers
- 47 people
- Sponsor
- The Higher Institute of Sport and Physical Education of Sfax
Chronic Renal Disease, Cardiovascular Disease
Dyslipidemia-related Risk Factors in Dialysis
In this study, we studied lipoprotein abnormalities-related variables as risk factors for the development of cardiovascular disease in patients on renal replacement therapies.We studied 96 dialyzed patients, 62 males and 34…
- Conditions
- Chronic Renal Disease, Cardiovascular Disease, Dyslipidemia
- Trial name
- NCT02072837
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Renal Impairment, Gout
Evaluation of Colchicine and Nonsteroidal Anti-inflammatory Drug Combination Therapy and Renal Function in Gout Patients
Our findings are expected to provide real-world evidence of the renal-adverse effects of colchicine and NSAIDs combination therapy in patients with gout, which will guide healthcare professions in optimizing gout treatment…
- Conditions
- Renal Impairment, Gout, Colchicine Adverse Reaction, Nonsteroidals (NSAIDs)Toxicity
- Trial name
- NCT05006001
- Testing
- Colchicine and NSAID
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- En Chu Kong Hospital
Chronic Kidney Diseases
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
- Trial name
- NCT04500665
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Chronic Kidney Diseases
KNOW-CKD Cohort, Phase II Study
The goals of KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) study are 1) to establish a CKD cohort representing Korean CKD population for up to 10-year follow-up, and 2) to investigate the…
- Trial name
- NCT03929900
- Where
- South Korea
- Volunteers
- 1,500 people
- Sponsor
- Seoul National University Hospital
End Stage Renal Disease (ESRD)
Effect of Medium Cut-Off Hemodialysis on Protein Energy Wasting: The EMCOPEW Study
In patients on maintenance hemodialysis (HD), protein energy wasting (PEW) defined as loss of muscle mass and fuel reserves of the body is frequent and associated with severe morbidity and mortality.
- Trial name
- EMCOPEW (NCT05309109)
- Testing
- Hemodialysis sessions
- Where
- 2 sites in France
- Volunteers
- 65 people
- Sponsor
- Poitiers University Hospital
Heart Disease, Renal Insufficiency
A Study of The Effectiveness of N-Acetylcysteine in Kidney Protection Following Cardiopulmonary Bypass
N-acetylcysteine is a medication that has most commonly been used in the past to prevent liver damage after an acetaminophen overdose.
- Trial name
- NCT00187330
- Testing
- Intravenous N-acetylcysteine
- Volunteers
- 104 people
- Sponsor
- Sunnybrook Health Sciences Centre
Renal Impairment
Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Renal Impairment Compared to Healthy Participants.
The purpose of this parallel group, Phase 1, open-label, 2-arm study is to assess the effect of severe (Part A) and moderate (Part B, conditional) renal impairment (RI) on pharmacokinetics (PK), safety and tolerability of…
- Trial name
- NCT05282030
- Testing
- tolebrutinib
- Where
- 4 sites in United States, Germany
- Volunteers
- 22 people
- Sponsor
- Sanofi
End Stage Renal Disease
Efficacy and Safety of XyloCore Peritoneal Dialysis Solution.
Randomized, controlled, parallel groups, open-label, blinded end-point assessment, multicenter study, comparing the effects of a low glucose peritoneal dialysis solution, XyloCore, to glucose solutions (Physioneal, Fixioneal…
- Trial name
- ELIXIR (NCT03994471)
- Testing
- XyloCore Low Strenght, XyloCore Medium Strenght, XyloCore High Strenght, 1.36%, 1.5%, 2.27%, 2.5%, 3.86%, 2.25% Glucose PD Solution
- Where
- 41 sites in Denmark, Germany and 4 more
- Volunteers
- 170 people
- Sponsor
- Iperboreal Pharma Srl
Renal Impairment, Diabetes
Pharmacokinetics of Vildagliptin in Mild, Moderate and Severe Renal Impaired Patients
This study assess the pharmacokinetics of vildagliptin in mild, moderate and severe renal impaired patients
- Trial name
- NCT00818571
- Testing
- Vildagliptin
- Where
- Russia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Congestive Heart Failure, Cardiorenal Syndrome
Nesiritide and Renal Function After the Total Artificial Heart
The prevalence of renal dysfunction after implantation of the artificial heart is high. The infusion of exogenous B-type natriuretic peptide (BNP) after implantation of the total artificial heart (TAH) improves renal function in…
- Trial name
- NCT01836809
- Testing
- nesiritide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
End Stage Renal Disease
Association of Middle Molecules Clearance With HDF Volume
HDF is a dialysis technique which involves diffusion and convection. HDF with high convection volume has consistently shown to improve survival in dialysis patients in number of robust RCTs.
- Trial name
- NCT06515899
- Where
- United Kingdom
- Volunteers
- 342 people
- Sponsor
- East and North Hertfordshire NHS Trust
End Stage Renal Disease
Effect of Lanthanum Carbonate in Patients Previously Treated With Calcium-based Phosphate Binder Therapy
To assess the percentage of patients on lanthanum carbonate, that achieve Kidney Disease Outcome Quality Initiative (KDOQI) guideline suggested values for serum phosphorous in patients previously treated with calcium-based…
- Trial name
- NCT01130831
- Testing
- Lanthanum carbonate
- Where
- 31 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Shire
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
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