Clinical trials: Kidney Insufficiency
Chronic Kidney Disease, Vitamin D Deficiency
Vitamin D, Chronic Kidney Disease (CKD) and the Microcirculation
Overall research aims: This study will examine the effect of vitamin D supplementation on the function of the endothelium and microcirculation of patients with chronic kidney disease and vitamin D deficiency.
- Trial name
- NCT00882401
- Testing
- Ergocalciferol (Vitamin D)
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Arteriovenous Fistulas, Renal Failure, End-Stage
Trial Comparing the Incidence of Steal Syndrome in the Two Types of anTEcubitaL Fossa Arteriovenous fistuLa AVF
Background: Arteriovenous fistula (AVF) is a form of vascular access for haemodialysis. An AVF is normally created at the level of the wrist, but occasionally it is created in the elbow when there is no suitable vessel in the…
- Conditions
- Arteriovenous Fistulas, Renal Failure, End-Stage, Steal Syndrome
- Trial name
- STEAL (NCT02297451)
- Testing
- Proximal radial/ulnar artery as inflow
- Where
- United Kingdom
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Acute Kidney Injury, Peritonitis
Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury
Phase 3 multicenter study to be conducted in up to 90 qualified participating sites globally to assess the efficacy and safety of Reltecimod vs placebo in patients with sepsis-associated Stage 2/3 AKI.
- Conditions
- Acute Kidney Injury, Peritonitis, Necrotizing Soft Tissue Infection
- Trial name
- NCT03403751
- Testing
- Reltecimod 0.5 mg/kg
- Where
- 56 sites in United States, France
- Volunteers
- 58 people
- Sponsor
- Atox Bio Ltd
Renal Failure
Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
pain control in pediatric renal transplant is a major concern. the main goal during anesthesia of renal transplant in pediatrics is to maintain hemodynamics in a range close to that of the adult donor.
- Trial name
- NCT02037802
- Testing
- B-Braun, Perifix® ONE Paed, Germany, Pethidine, Propofol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Cardio-renal Syndrome
Ultrafiltration Versus Medical Therapies in the Management of the Cardio Renal Syndrome
Type 2 cardio renal syndrome is defined by the occurrence or the exacerbation of a kidney failure induced by a chronic heart failure.
- Trial name
- UF-CARE (NCT02846337)
- Testing
- ULTRAFILTRATION, ENHANCED MEDICAL TREATMENT
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Cardiac Surgery Associated - Acute Kidney Injury
Perioperative Role Of Vascular Endothelial Growth Factor In Cardiac Surgery-associated Acute Kidney Injury
The goal of this prospective observational study is to find out whether the protein vascular endothelial growth factor (VEGF) measured in blood and urine can predict which patients will develop acute kidney injury (AKI) after…
- Trial name
- PROVE-AKI (NCT07803328)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Universität Münster
End Stage Kidney Disease
Duke APOL1 Research Biorepository
The Duke ApoL1 Nephropathy Biorepository aims to address needs within non-diabetic kidney failure research by utilizing existing and, when necessary, developing new infrastructure to support the consent of patients and the…
- Trial name
- DARB (NCT04160507)
- Testing
- Biorepository
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Duke University
Continuous Renal Replacement Therapy, Renal Failure
Post-Filter Hematocrit
Filter clotting is a major complication of continuous renal replacement therapy (CRRT), resulting in blood loss, reduced treatment efficacy, and increased cost.
- Conditions
- Continuous Renal Replacement Therapy, Renal Failure, Hemofilter Clotting
- Trial name
- CRRTHCT (NCT07293936)
- Testing
- Calculated Post-Filter Hematocrit, Measured Post-Filter Hematocrit
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Gwyndolyn M. Radford
ESRD
Physician Reimbursement Home Patients
This is an observational study using an online survey to solicit information from nephrologists who care for dialysis patients about the time and effort involved in providing care to home dialysis patients.
- Trial name
- NCT05011136
- Testing
- No intervention. This is a qualitative study
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Satellite Healthcare
End Stage Renal Disease on Hemodialysis (Diagnosis)
HEPLISAV-B® in Adults With End-Stage Renal Disease (ESRD) Undergoing Hemodialysis
This is an open-label, single arm study design to evaluate HEPLISAV-B® in adults with ESRD who are initiating or undergoing hemodialysis.
- Trial name
- NCT03934736
- Testing
- HEPLISAV-B®
- Where
- 20 sites in United States
- Volunteers
- 119 people
- Sponsor
- Dynavax Technologies Corporation
Chronic Kidney Disease
Dialysis Clinical Outcomes Revisited (DCOR) Trial
This is a randomized, open-label, parallel-design study to be conducted at 75 centers within the United States. The study will be described to hemodialysis patients.
- Trial name
- NCT00324571
- Testing
- Sevelamer hydrochloride, Calcium-based phosphate binder
- Where
- 73 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- Genzyme, a Sanofi Company
Chronic Kidney Disease, Proteinuria
Optimalization of Nephroprotection Using Atorvastatin (Sortis)
The main purpose of the study is find whether the addition of statin (Atorvastatin) to dual renin-angiotensin-aldosterone system blockade involving angiotensin converting enzyme inhibitor and AT-1 angiotensin II receptor blocker…
- Trial name
- NCT00572312
- Testing
- atorvastatin (Sortis) 40 mg
- Sponsor
- Medical University of Gdansk
Hemodialysis Patients
Effects of Exercise Program on Physical Functioning of Hemodialysis Patients.
This study is designed to provide a simple, home-based, low-moderate intensity exercise program in chronic renal disease patients who are undergoing hemodialysis in order to improve physical performance, decrease the level of…
- Trial name
- NCT04674930
- Testing
- Exercise program
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Diabetes Mellitus, Coronary Artery Bypass
Remote Ischemic Preconditioning in Type 2 Diabetic Patients Undergoing CABG
This randomized, double-blind, prospective clinical trial aims to investigate the effect of remote ischemic preconditioning (RIPC) on myocardial protection in patients with type 2 diabetes mellitus undergoing elective coronary…
- Conditions
- Diabetes Mellitus, Coronary Artery Bypass, Remote Ischaemic Conditioning
- Trial name
- NCT06977230
- Testing
- Remote Ischemic Preconditioning
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Muğla Sıtkı Koçman University
Chronic Kidney Disease, Hyperkalemia
Dietary Potassium Liberalization in Pre-Dialysis Patients
The study will look at the impact of the potassium content in fruits and vegetables, on serum potassium concentrations in people with Chronic Kidney Disease (CKD) using a randomized crossover design.
- Trial name
- DK-LIB (NCT05090865)
- Testing
- Liberalized dietary potassium via fruits and vegetables, Standard dietary potassium restriction
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Chronic Renal Failure
Removal of Uremic Toxins With Nocturnal Dialysis Versus Standard Dialysis
Dialysis patients, who decide to switch from standard dialysis (3 times 240-270 min/week) to nocturnal dialysis (3 times 480 min/week), will be followed.
- Trial name
- NCT00766792
- Testing
- Nocturnal dialysis, Standard dialysis
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- University Hospital, Ghent
Acute Kidney Injury
Oral Salt and Water to Prevent Contrast Nephropathy
The purpose of this pilot trial is to determine the safety and feasibility of using oral salt and water loading compared to intravenous saline for the prevention of contrast-induced acute kidney injury in patients with chronic…
- Trial name
- NCT02084771
- Testing
- Intravenous Saline, Oral Salt and Water
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Chronic Kidney Diseases, Osteodystrophy
Effect of Allopurinol on Markers of Mineral and Bone Metabolism
Hyperuricemia is a common condition in patients with chronic kidney disease (CKD) in the glomerular filtration rate. Recently, it has been suggested that uric acid is related to a mineral and bone disease of CKD (CKD-MBD) since…
- Conditions
- Chronic Kidney Diseases, Osteodystrophy, Uric Acid Concentration, Serum, Quantitative Trait Locus 7
- Trial name
- NCT05601271
- Testing
- Allopurinol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Sarcopenia, Renal Insufficiency, Chronic
Exercise During Hemodialysis: Impact on Sarcopenia and Sleep Quality
Sarcopenia (the loss of muscle mass, strength, and function) is highly prevalent in patients with Chronic Kidney Disease (CKD) undergoing hemodialysis, significantly increasing the risk of falls, frailty, and mortality.
- Trial name
- NCT07447375
- Testing
- Intradialytic Personalized Exercise Program.
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- University of Salamanca
Renal Impairment
A Phase l Study to Evaluate the Pharmacokinetics and Safety Pasireotide in Subjects With Varying Degrees of Renal Impairment Compared to Healthy Volunteers
The purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) of pasireotide,the PK of pasireotide in subjects with different degrees of renal impairment.
- Trial name
- NCT01578928
- Testing
- SOM230
- Where
- 2 sites in Germany, South Africa
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
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