Clinical trials: Kidney Insufficiency
Acute Kidney Injury
Renal Safety of Bowel Preparation With Polyethylene Glycol
This study evaluates the changes of renal function after taking bowel cleansing agent polyethylene glycol for elective colonoscopy.
- Trial name
- NCT02657564
- Testing
- Polyethylene glycol (PEG)
- Where
- Taiwan
- Volunteers
- 1,237 people
- Sponsor
- Evergreen General Hospital, Taiwan
Acute Kidney Injury
Renal Oximetry-Guided Anesthesia With Near-Infrared Spectroscopy for Improved Postoperative Outcomes
The trial is a prospective, randomized, single-blind, pilot study investigating whether near-infrared spectroscopy (NIRS)-guided optimization of intraoperative renal oxygen saturation reduces postoperative acute kidney injury…
- Trial name
- ROGAR (NCT07141693)
- Testing
- NIRS-guided management, Standard anesthesia management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital
Chronic Kidney Disease (Stages 3b-5), Mild Cognitive Disorder
Early Detection, Remote Augmented Reality Combined Rehabilitation Therapy, and Translational Therapy for Patients With Chronic Kidney Disease and Cognitive Disorder
More than half of the patients with nephropathy have cognitive impairment, which can reach the level of dementia.The decline of renal function is more serious.
- Trial name
- NCT07272733
- Testing
- Ketosteril
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Taipei Medical University Hospital
Hypotension, Brain Injuries
Correlation Between Circulating Biomarkers of Organs Damage and Intraoperative Hypotension Management
Intraoperative hypotension (defined as mean arterial pressure below 65 mmHg) is associated with increased organs dysfunction and mortality.
- Conditions
- Hypotension, Brain Injuries, Renal Failure, Endothelial Dysfunction
- Trial name
- NCT03527758
- Testing
- Flo TracIQ with HPI software
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Acute Kidney Injury
Preconditioning Against Renal Damage Under Contrast Examination
This study aims to assess if applying an ischaemic insult to an arm before giving intravenous contrast will help decrease the incidence of developing contrast induced acute renal injury in patients undergoing contrast-enhanced CT…
- Trial name
- Re-DUCE-F (NCT02054858)
- Testing
- RIPC
- Where
- Ireland
- Volunteers
- 1,000 people
- Sponsor
- Mid Western Regional Hospital, Ireland
Multiple Myeloma, Advanced Solid Tumors
Pharmacokinetics Study of Oral Ixazomib (MLN9708) in Relapsed/Refractory Multiple Myeloma and Advanced Solid Tumors Participants With Normal Renal Function or Severe Renal Impairment
The purpose of this study is to characterize the single-dose pharmacokinetic (PK) parameters of ixazomib (MLN9708) in cancer participants with either normal renal function or severe renal impairment (RI), including participants…
- Trial name
- NCT01830816
- Testing
- Ixazomib
- Where
- 11 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
General Surgery
The GUARDIAN Pilot Trial
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP ≥80 mmHg (tight pressure management)…
- Trial name
- GUARDIAN (NCT04789733)
- Testing
- Tight pressure management, Routine pressure management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Renal Insufficiency, Chronic
Effects of Fasting Mimetic Diet on Nephropatic Patients
Fasting mimetic diet (FMD) showed positive effects on cardiovascular risks. Purpose of the trial is to evaluate FMD effects on patients affected by chronic kidney disease (CKD), through the stimulation of kidney stem cells and…
- Trial name
- NCT04490252
- Testing
- Fasting mimetic diet
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- University of Roma La Sapienza
Chronic Kidney Disease
Clearance of 25-hydroxyvitamin D in Chronic Kidney Disease
The goal of this study is to better understand vitamin D catabolism and how it is affected by CKD and race.
- Trial name
- CLEAR (NCT02937350)
- Testing
- D6-25-hydroxyvitamin D3
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Washington
Renal Impairment, Multiple Myeloma
PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function
This was a multicenter study of the pharmacokinetics (PK) of melphalan during treatment with melflufen and dexamethasone in patients with relapsed refractory multiple myeloma (RRMM) and impaired renal function.
- Trial name
- BRIDGE (NCT03639610)
- Testing
- Melflufen, Dexamethasone
- Where
- 10 sites in Czechia, Greece and 1 more
- Volunteers
- 35 people
- Sponsor
- Oncopeptides AB
Congestive Heart Failure, Renal Impairment
Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients
A study to determine the most appropriate dose of MK7418 in heart failure patients presenting with symptoms of volume overload requiring increased diuretic doses.
- Trial name
- NCT00652782
- Testing
- rolofyline
- Volunteers
- 160 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Kidney Diseases
Developing Tools for Dialysis Decision Support
The aim of this study is to evaluate the impact of a web-based dialysis decision support tool on decisional conflict, and values-treatment concordance and other decisional outcomes in individuals with advanced chronic kidney…
- Trial name
- NCT06597279
- Testing
- Web-based dialysis decision support tool
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- VA Palo Alto Health Care System
Atrial Fibrillation, Atrial Flutter
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2)
People receiving dialysis are more likely to develop atrial fibrillation (AF), an irregular heartbeat that increases the risk of stroke.
- Conditions
- Atrial Fibrillation, Atrial Flutter, End Stage Kidney Disease (ESRD), Dialysis Patients
- Trial name
- SAFE-D2 (NCT07779746)
- Testing
- Eliquis, No oral anticoagulation
- Volunteers
- 848 people
- Sponsor
- Unity Health Toronto
Kidney Disease, Chronic
A Study to Test BI 764198 in People With a Type of Kidney Disease Called Focal Segmental Glomerulosclerosis
This study is open to adults with a type of kidney disease called focal segmental glomerulosclerosis (FSGS). The purpose of this study is to find out whether a medicine called BI 764198 improves the health of the kidneys in…
- Trial name
- NCT05213624
- Testing
- BI 764198
- Where
- 54 sites in United States, Australia and 8 more
- Volunteers
- 67 people
- Sponsor
- Boehringer Ingelheim
Acute Kidney Injury
Molecular Effects of Vitamin B3 (Niacinamide) in Acute Kidney Injury
This is a single center, randomized, single-blind, placebo-controlled study to evaluate the safety and biochemical effects of niacinamide on metabolic parameters of the kidney in patients undergoing cardiac surgery.
- Trial name
- NCT02701127
- Testing
- Oral niacinamide, 1 gram daily, Oral niacinamide, 3 gram daily
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Beth Israel Deaconess Medical Center
Palliative Care, Renal Failure, End-stage
Effects of a Transitional Palliative Care Model on Patients With End-stage Renal Failure
Primary aim: 1. To compare the effects of customary care and an interventional Home-based Palliative Renal Program (HBPRP) for ESRF patients 2.
- Trial name
- ESRF (NCT02139917)
- Testing
- Transitional community based palliative care
- Where
- Hong Kong
- Volunteers
- 76 people
- Sponsor
- The Hong Kong Polytechnic University
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
End-Stage Renal Disease
Study of HemoCare™ Hemodialysis System for Home Nocturnal Dialysis in Patients With ESRD
This prospective multi-center, open-label, single-arm study intends to gather and evaluate safety data for the nocturnal use of the HemoCare™ Hemodialysis System.
- Trial name
- NCT04087213
- Testing
- HemoCare™ Hemodialysis System
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Deka Research and Development
Acute-On-Chronic Liver Failure, Hepatorenal Syndrome
Efficacy of Early Terlipressin Plus Albumin Therapy in Comparison to Standard Treatment for HRS-AKI in Acute-on-chronic Liver Failure.
Acute on chronic liver failure (ACLF) is a distinct entity where, because of severe acute hepatic injury, a rapid loss of liver function develops in a patient with previous chronic liver disease(4).
- Conditions
- Acute-On-Chronic Liver Failure, Hepatorenal Syndrome, Acute Kidney Injury
- Trial name
- NCT04416282
- Testing
- Terlipressin, Albumin
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Renal Insufficiency, Chronic, Proteinuria
Effect of RAS Blockers on CKD Progression in Elderly Patients With Non Proteinuric Nephropathies (PROERCAN01)
This study evaluates the effect of renin-angiotensin blockers on chronic kidney disease progression in elderly (>65 years old) patients with non-proteinuric nephropathies.
- Trial name
- PROERCAN01 (NCT03195023)
- Testing
- Lisinopril, Amlodipine
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
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