Clinical trials: Kidney Replacement
Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT)
Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)
The purpose of this research is to determine if an investigational new drug solution called Prismocitrate 18 lengthens extracorporeal circuit life in patients treated with continuous renal replacement therapy (CRRT).
- Conditions
- Regional Citrate Anticoagulation (RCA), Continuous Renal Replacement Therapy (CRRT), Acute Kidney Injury
- Trial name
- NCT02860130
- Testing
- Prismocitrate 18, No Anticoagulation
- Where
- 12 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Vantive Health LLC
Renal Replacement Therapy for Acute Kidney Injury in ICU, Continuous Renal Replacement Therapy (CRRT)
Continuous Renal Replacement Therapy Doses in Critically Ill Patients With Acute Kidney Injury
Acute kidney injury in critically ill patients admitted to the ICU is a common complication associated with high mortality or long-term chronic kidney damage.
- Trial name
- CRRIT1 (NCT06901011)
- Testing
- continuous renal replacement therapy
- Volunteers
- 100 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study
What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically…
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT), Filter Clotting, Microbubbles
- Trial name
- NCT07005531
- Testing
- Ultrasound-Guided Microbubble Clearance During Circuit Priming
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Uremic Pruritus, Chronic Kidney Disease-associated Pruritus
Fexofenadine Versus Gabapentin for Uremic Pruritus in Patients on Regular Hemodialysis
Several studies investigated the effectiveness of Gabapentin in Uremic Pruritus (UP). No previous studies investigated the use of fexofenadine in UP.
- Conditions
- Uremic Pruritus, Chronic Kidney Disease-associated Pruritus, Hemodialysis, End-stage Renal Disease
- Trial name
- NCT06466421
- Testing
- Fexofenadine, Gabapentin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Renal Replacement Therapies, Outcome Assessment
Outcomes of Critically Ill Patients Undergoing RRT- a Registry Based Study.
Rationale: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a frequently occurring entity among critically ill patients.
- Trial name
- NCT06897254
- Where
- Nepal
- Volunteers
- 516 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Kidney Transplant Rejection, Kidney Replacement
Utilising Volumetric Absorptive Microsampling (VAMS) Technology to Monitor Tacrolimus and Creatinine
Tacrolimus is a medicine given to try and stop rejection of a new kidney after transplant surgery. If too much taken the kidney may be damaged. If not enough taken, the risk of rejection is increased.
- Trial name
- NCT06445205
- Testing
- Mitra® device with VAMS® (volumetric absorptive microsampling) technology
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Lancashire Teaching Hospitals NHS Foundation Trust
Chronic Kidney Diseases, Elderly
AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients
With the aging population, a high prevalence of obesity, systemic arterial hypertension and diabetes mellitus, we are facing an increased incidence of elderly patients with chronic kidney disease (CKD) initiating renal…
- Conditions
- Chronic Kidney Diseases, Elderly, Mortality, Renal Replacement Therapy
- Trial name
- AGNES (NCT04132492)
- Testing
- no intervention
- Where
- 2 sites in Brazil
- Volunteers
- 151 people
- Sponsor
- University of Sao Paulo General Hospital
Fluid Overload, Acute Kidney Injury
Perfusion Parameters and Outcome During a Standardized Deresuscitation Strategy with Net Ultrafiltration: a Retrospective Cohort Study.
Hemodynamic tolerance of fluid removal during deresuscitation is a cornerstone of the impact on outcome of such a strategy. However, how to define and to predict hemodynamic tolerance to fluid removal remains controversial.
- Conditions
- Fluid Overload, Acute Kidney Injury, Continuous Renal Replacement Therapy
- Trial name
- DeepCART (NCT06899880)
- Testing
- Describe the perfusion parameters during a deresuscitation strategy and their association with the outcome.
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Kidney Replacement
Pilot of IMPACT Intervention at the University of New Mexico
Kidney transplant recipients (KTR) are at greater risk of weight gain, diabetes and cardiovascular events post-transplant; but medications are limited in their effectiveness, and patients may face contraindications and unwanted…
- Trial name
- IMPACT (NCT04166994)
- Testing
- Exercise and diet, No Intervention: Usual Care
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of New Mexico
Critically Ill, Continuous Renal Replacement Therapy
Filter Lifespan in Continuous Renal Replacement Therapy
The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored.
- Conditions
- Critically Ill, Continuous Renal Replacement Therapy, Infections
- Trial name
- CRRTInfO (NCT05450185)
- Testing
- Critically ill patients with continuous renal replacement therapy
- Where
- 5 sites in Austria, Brazil and 1 more
- Volunteers
- 600 people
- Sponsor
- University Hospital Muenster
Peritoneal Dialysis, Hemodialysis, Home
Experiences and Health-related Quality of Life of Informal Caregivers of Dialysis Patients
The goal of this prospective, observational, multicentre cohort study is to assess the trajectory of the experiences (both positive and negative) and health-related quality of life (HRQOL) of informal caregivers of patients who…
- Conditions
- Peritoneal Dialysis, Hemodialysis, Home, Hemodialysis, Quality of Life
- Trial name
- NCT05646615
- Where
- 33 sites in Belgium, Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- B.C. van Jaarsveld
Kidney Replacement
Kidney Perfusion With or Without Absorption
In this single-center, pilot, prospective, randomized study, the investigators will compare the biochemical profiles of the perfusate and the functional parameters of five kidneys perfused with Integrated PerLife® system and…
- Trial name
- POWER (NCT06374121)
- Testing
- PerSorb cartridge (CytoSorbents Europe GmbH, Germany), PerLife PerKidney
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Acute Kidney Injury, Intensive Care
The Cost-effectiveness of Artificial Intelligence Acute Kidney Injury Prediction Auxiliary Software (Acura AKI)
"Huede" AI Aided AKI Prediction Software, Acura AKI, uses machine learning algorithms to predict the risk of AKI within the next 24 hours and provide a ranking of feature importance.
- Conditions
- Acute Kidney Injury, Intensive Care, Renal Replacement Therapy
- Trial name
- NCT06685367
- Testing
- Acura AKI
- Where
- Taiwan
- Volunteers
- 3,600 people
- Sponsor
- Huede Healthtech Co., Ltd.
Septic Shock, Renal Function Replacement
Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock
The aim of the present study is to verify whether the earlier association of vasopressin and norepinephrine, in patients in septic shock, determines variations in terms of use of renal function replacement techniques in the first…
- Trial name
- EVSS (NCT06471231)
- Testing
- vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.25 mcg/kg/min, vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.5 mcg/kg/min
- Where
- Italy
- Volunteers
- 264 people
- Sponsor
- Azienda Usl di Bologna
Fluid Removal, Critically Ill
Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy
Macrohemodynamic impact of fluid removal with net ultrafiltration in patients with continuous renal replacement therapy. A monocentric ancillary study of the EarlyDry randomized controlled trial.
- Conditions
- Fluid Removal, Critically Ill, Continuous Renal Replacement Therapy, Fluid Overload
- Trial name
- NCT06425289
- Testing
- Macrohemodynamic parameters
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Cardiogenic Shock, Renal Replacement Therapy
REnal reCOVery After ECMO for Cardiogenic Shock (RECOVECMO)
This retrospective study assesses long term renal outcome in patients having suffered medical or post cardiotomy refractory cardiogenic shock requiring renal replacement therapy (RRT) concomitant with veno-arterial extracorporeal…
- Conditions
- Cardiogenic Shock, Renal Replacement Therapy, Venoarterial Extracorporeal Membrane Oxygenation
- Trial name
- RECOVECMO (NCT05788211)
- Testing
- standard of care
- Where
- France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Bordeaux
AKI, Continuous Renal Replacement Therapy
Renal Physiology During Continuous Renal Replacement Therapy
Approximately 50% of patients in the intensive care unit (ICU) develop acute kidney injury (AKI) and more than 10% need dialysis. There is no treatment for AKI.
- Conditions
- AKI, Continuous Renal Replacement Therapy, Dialysis, Intensive Care
- Trial name
- NCT04114747
- Testing
- Starting at high or low blood pressure
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Critically Ill, Acute Kidney Injury
Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation
The primary objectives of the BiPhox-Trial are to demonstrate, that the use of Biphozyl® as a replacement fluid in adult critically ill acute kidney injury (AKI) patients, results in a lower rate of pH excursions and of…
- Conditions
- Critically Ill, Acute Kidney Injury, Renal Replacement Therapy, Continuous Renal Replacement Therapy
- Trial name
- NCT04071171
- Testing
- CVVH with Phoxilium® in the first 48h after randomization, CVVH with Biphozyl® in the first 48h after randomization, CVVH with Phoxilium® in the second 48h after randomization (after previous 48h with Biphozyl®)
- Where
- Austria
- Volunteers
- 88 people
- Sponsor
- Medical University Innsbruck
Acute Kidney Injury, Continuous Renal Replacement Therapy
Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood
Acute kidney injury (AKI) is common in intensive care unit (ICU) patients and is associated with longer hospital stays and worse survival.
- Trial name
- NCT04103307
- Testing
- Dialysis cooling
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's