Clinical trials: Kidney Replacement
Acute Renal Failure, Infection
Efficacy and Safety of Ethanol Lock Solution in Prevention of Catheter Related Bloodstream Infection for Patients Suffering Acute Renal Failure, and Hospitalized in Intensive Care Unit. A Multi-Center, Randomized, Versus Placebo, Double Blinded Clinical Trial
The primary objective of the study is to demonstrate the efficacy of 60% ethanol lock solution in preventing major catheter related infections in critically ill patients.
- Trial name
- ELVIS (NCT00875069)
- Testing
- Ethanol
- Where
- France
- Volunteers
- 1,460 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Kidney Injury, Sepsis
Continuous Renal Replacement Therapy With Oxiris in Acute Kidney Injury and Sepsis
It is an epidemiology study to explore outcomes in patients with acute kidney injury (AKI) and sepsis submitted to continuous renal replacement therapy (CRRT) with Oxiris™.
- Trial name
- NCT06253377
- Testing
- Adsorption membrane filter Oxiris™
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nefro Consultoria de Doenças Renais Ltda
CKD With Hepatitis C
Safety and Efficacy of Sofosbuvir Based Antiviral Regimen for Treating Hepatitis C in Patients With Moderate to Advanced Chronic Kidney Disease and Patients Receiving Renal Replacement Therapy
All patients with chronic kidney disease (stages 3, 4 and 5) and chronic dialysis patients with HCV infection attending nephrology and Hepatology OPD or getting outpatient dialysis at the dialysis unit of ILBS.
- Trial name
- NCT02563665
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Renal Insufficiency
Factors Related to Geographical Variation in the Incidence of End-stage Renal Failure: An Analysis in 5 French Regions
The REIN registry highlights significant disparities in the incidence of end-stage renal disease (ESRD) between regions, especially in the North East of France.
- Trial name
- VIgIE (NCT02849964)
- Where
- 4 sites in France
- Volunteers
- 6,835 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Kidney Failure
Prostacyclin's Effect on Platelet Responsiveness
The researchers investigated the influence of a prostacyclin analogue (PGIA) versus unfractionated heparin (UFH) on ex vivo platelet function, during continuous venovenous hemodiafiltration.
- Trial name
- NCT00890214
- Testing
- prostacyclin, heparin
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Peritoneal Dialysis, Hemodialysis, Home
Experiences and Health-related Quality of Life of Informal Caregivers of Dialysis Patients
The goal of this prospective, observational, multicentre cohort study is to assess the trajectory of the experiences (both positive and negative) and health-related quality of life (HRQOL) of informal caregivers of patients who…
- Conditions
- Peritoneal Dialysis, Hemodialysis, Home, Hemodialysis, Quality of Life
- Trial name
- NCT05646615
- Where
- 33 sites in Belgium, Netherlands
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- B.C. van Jaarsveld
Peritoneal Dialysis (PD), Hemodialysis
A Survey for Patients and Caregivers Aiming to Understand and Improve the Care of Patients at High Risk of Transfer From Peritoneal Dialysis to Hemodialysis:
Home dialysis is encouraged in Canada and peritoneal dialysis is the most common home dialysis method. However, many patients discontinue peritoneal dialysis, often transferring to hemodialysis.
- Conditions
- Peritoneal Dialysis (PD), Hemodialysis, Kidney Replacement Therapy, Transition
- Trial name
- ULIFT-PD (NCT07437677)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Renal Failure, Acute Kidney Injury
A Clinical Model for Dialysis Discontinuation in AKI
A retrospective study evaluating AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the "Success" group, as opposed to the…
- Trial name
- NCT06005896
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Kidney Injury
Safety and Efficacy of a Selective Cytopheretic Device (SCD) in Pediatric Patients With Acute Kidney Injury (AKI).
The SCD (Selective Cytopheretic Device) is an extracorporeal device used as an adjunct to renal replacement therapy (RRT) to improve the outcomes of pediatric patients with acute kidney injury (AKI).
- Trial name
- SCD-PED-01 (NCT02820350)
- Testing
- SCD-F40
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- CytoPherx, Inc
Acute Kidney Injury
Nafamostat Efficacy and Safety in Critically Ill Patients(NICE)
Acute kidney injury (AKI) is a common and serious problem in critically ill patients, and is known to be an independent risk factor for mortality.
- Trial name
- NCT01486485
- Testing
- heparinized saline priming group, nafamostat infusion after heparinized saline priming
- Where
- 4 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Kidney Neoplasms, Renal Insufficiency
A Clinical Study of the Living Renal Transplantation With Restored Kidneys Between Third Parties
Approximately 30,000 new patients are introduced into dialysis and about 20,000 of them die every year in Japan. At present, about 300,000 patients are on dialysis and more than 10,000 patients are registered to the Japan Organ…
- Conditions
- Kidney Neoplasms, Renal Insufficiency, Renal Replacement Therapy
- Trial name
- NCT00980317
- Testing
- Restored Kidney Transplant Between Third Parties
- Where
- 2 sites in Japan
- Volunteers
- 5 people
- Sponsor
- Tokushukai Medical Group
Renal Replacement Therapy, Acute Kidney Injury
Saline Versus Albumin Fluid for Extracorporeal Removal With Slow Low Efficiency Dialysis Feasibility Study
Objective: The primary aim of this 60 patient feasibility trial is to determine if, for critically ill patients treated with SLED for AKI, randomization to receive albumin (25%) boluses versus normal saline placebo boluses is…
- Conditions
- Renal Replacement Therapy, Acute Kidney Injury, Hypotension
- Trial name
- SAFER-SLED (NCT03665311)
- Testing
- 25% Albumin fluid, Normal Saline
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Hypogonadism
Testosterone Replacement in Renal Failure
The purpose of this trial is to evaluate the effect of testosterone replacement in men with renal failure (on dialysis) who also have low testosterone.
- Trial name
- NCT02712944
- Testing
- Testosterone, Saline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Texas Tech University Health Sciences Center
Respiratory Failure With Hypercapnia
The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal
In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, in model of continuous veno-venous hemofiltration (CVVH) , the HCO3- concentration in the pre…
- Trial name
- NCT05989971
- Testing
- continuous renal replacement therapy
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southeast University, China
Secondary Hypothyroidism
Thyroid Function in Critically Ill Patients With Acute Kidney Injury
The objective of this study was to assess the changes in thyroid hormones and its activity during CRRT in patients with Acute Kidney Injury.
- Trial name
- NCT04767763
- Testing
- Assessment of TSH, fT3, fT4,TRH, TT3, TT4, rT3 in patients with CVVHDF
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Gdansk
Acute Kidney Injury
Proenkephalin A and Kidney Replacement Therapy
Acute kidney injury (AKI) is a common problem encountered in the intensive care unit (ICU), estimated to occur in up to 60% of all critically ill patients, depending on the definition.
- Trial name
- NCT04879706
- Testing
- None planned
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- University of Giessen
Acute Renal Failure
Mineral-Homeostasis in Continuous Renal Replacement Therapy
Acute renal failure is a common complication in intensive care unit patients. In 10% of cases renal replacement therapy becomes necessary. Current devices have increase filter patency and efficacy.
- Trial name
- NCT01946113
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Acute Kidney Injury, Fluid Overload
Use of Biomarkers to Optimize Fluid Dosing,CRRT Initiation and Discontinuation in Pediatric ICU Patients With AKI
Acute Kidney Injury (AKI) is a common clinical problem defined by an abrupt (< 48 hour) increase in serum creatinine (SCr) resulting from an injury or insult that causes a functional or structural change in the kidney.
- Trial name
- NCT01416298
- Testing
- Continuous Renal Replacement Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Kidney Injury, Kidney Failure Chronic
French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units
Acute Kidney Injury (AKI) is a common and serious condition in hospitalized patients, especially when it reaches stages 2 or 3 according to the KDIGO classification.
- Conditions
- Acute Kidney Injury, Kidney Failure Chronic, Cardiorenal Syndrome, Renal Replacement Therapies
- Trial name
- FAKIR (NCT07123324)
- Volunteers
- 750 people
- Sponsor
- University Hospital, Strasbourg, France