Clinical trials: Kidney Replacement
Machine Learning, Acute Kidney Injury
Machine Learning Predict Renal Replacement Therapy After Cardiac Surgery
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication which may result in adverse impact on short- and long-term mortality.
- Conditions
- Machine Learning, Acute Kidney Injury, Renal Replacement Therapy, Prediction Models
- Trial name
- NCT04977687
- Where
- China
- Volunteers
- 2,108 people
- Sponsor
- Chinese PLA General Hospital
Acute Kidney Injury
Dexmedetomidine Pharmacokinetics During Continuous Renal Replacement Therapy (CRRT)
The purpose of this study is to determine dexmedetomidine pharmacokinetics during continuous renal replacement therapy on critically ill patients.
- Trial name
- NCT01314209
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 10 people
- Sponsor
- Helsinki University Central Hospital
Sepsis, Acute Kidney Injury
Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury
This multicenter, randomized, open-label, active-controlled, parallel-group trial will evaluate the efficacy and safety of nafamostat mesylate anticoagulation compared with regional citrate anticoagulation in adult patients with…
- Conditions
- Sepsis, Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- NICE-AKI (NCT07518303)
- Testing
- Citrate anticoagulation, Nafamostat Mesylate
- Volunteers
- 1,162 people
- Sponsor
- Jianfeng Xie
Acute Kidney Injury
Citrate-based Regional Anticoagulation Versus Heparin for Continuous Renal Replacement Therapy
Critically ill patients with acute kidney injury (AKI) are at high risk of bleeding on account of coagulopathy, platelet dysfunction, frequent liver dysfunction and invasive procedures.In patients at high risk of bleeding…
- Trial name
- NCT01269112
- Testing
- citrate regional anticoagulation
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Geneva
Acute Renal Failure
Furosemide in Early Acute Kidney Injury
Acute renal failure, now referred to as acute kidney injury, is common in intensive care unit patients, contributes to high morbidity and mortality, and has no proven interventions with benefit once established.
- Trial name
- SPARK (NCT00978354)
- Testing
- Furosemide, Normal Saline
- Where
- 4 sites in Australia, Canada
- Volunteers
- 72 people
- Sponsor
- University of Alberta
Acute Kidney Injury
Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared to standard initiation…
- Trial name
- NCT02568722
- Testing
- Standard RRT initiation, Accelerated RRT initiation
- Where
- 105 sites in United States, Australia and 13 more
- Volunteers
- 3,019 people
- Sponsor
- Unity Health Toronto
Intradialytic Hypotension, Intensive Care Unit ICU
Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients
This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent…
- Conditions
- Intradialytic Hypotension, Intensive Care Unit ICU, Hemodialysis Patients
- Trial name
- HyPIR-ICU (NCT07179705)
- Testing
- Hypotensive prediction index, Standard of care monitoring
- Where
- Thailand
- Volunteers
- 46 people
- Sponsor
- Chulalongkorn University
Chronic Renal Disease
Decision Support for the Renal Replacement Therapy With End-stage Renal Disease
Patients often need more comprehensive information and clearer communication in order to to understand the complications, risks, cost and impacts on life quality associated with different treatment options.
- Trial name
- NCT03921437
- Testing
- decision support intervention
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Acute Kidney Injury
Analysis of Clinical Outcomes in Patients Undergoing Acute Dialysis Therapy at Intensive Care Units
Acute kidney injury is more frequent and the mortality rate would be as high as 50-60% when the renal replacement therapy was needed.
- Trial name
- NCT01039753
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
Patients Undergoing Continuous Venovenous Hemodiafiltration: Effects of Increased Blood Flow
Acute Kidney Injure (AKI) is a syndrome with high incidence and prevalence in Intensive Care Units (ICU). It is estimated that 50% of the in the sector present AKI at some point and 10 to 15% require renal replacement therapy…
- Trial name
- NCT05796661
- Testing
- Effects of increased blood flow during regional anticoagulation with 4% trisodium citrate in patients undergoing continuous venovenous hemodiafiltration
- Where
- Brazil
- Volunteers
- 27 people
- Sponsor
- Hospital Israelita Albert Einstein
Renal Dialysis, Renal Replacement Therapy
Machine Learning and Artificial Intelligence Algorithms to Optimize the Performance and Delivery of Acute Dialysis
SMART DIALYSIS - Scaling Machine Learning and Artificial Intelligence AlgoRithms to OpTimize the Performance and Delivery of Acute DIALYSIS.
- Conditions
- Renal Dialysis, Renal Replacement Therapy, Renal Diseases, Quality Health Care
- Trial name
- SMART DIALYSIS (NCT07312929)
- Testing
- intermittent OR continuous renal replacement therapies
- Where
- 15 sites in Canada
- Volunteers
- 7,500 people
- Sponsor
- University of Alberta
Acute Kidney Injury, Acute Kidney Failure Stage 3
The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning
Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU…
- Trial name
- NCT04622384
- Testing
- Dialysis weaning
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Johan Fridolf Hermansen
Acute Kidney Injury
PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin
The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and…
- Trial name
- PRESSING (NCT06714214)
- Where
- 2 sites in Italy
- Volunteers
- 152 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Renal Failure, Chronic Kidney Disease
Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony
Analysis and comparison of treatments with and without the FlexPoint technology (flexible volume and dwell time management) of the PD cycler sleep•safe harmony
- Trial name
- FlexPoint (NCT06390592)
- Testing
- PD cycler
- Volunteers
- 24 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Acute Kidney Injury, Hypothermia
Hypothermia Risk With Continuous Renal Replacement Therapy
The present study aims at testing if the TherMax blood warmer is more accurate and reliable in reaching and maintaining chosen target temperature during continuous renal replacement therapy as compared to the Prismaflo IIS blood…
- Trial name
- HR-CRRT (NCT03973814)
- Testing
- Thermax Blood Warmer
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Heart Valve Disease, Older Than 18-years-old
The Pharmacogenetics of Optimal Warfarin Therapy in Chinese Patients After Heart Valve Replacement.
To value the accuracy of the dosing algorithm published by the International Warfarin Pharmacogenetics Consortium in Chinese patients after heart valve replacement.
- Conditions
- Heart Valve Disease, Older Than 18-years-old, Without Any Liver or Kidney Diseases
- Trial name
- POWAT (NCT02710747)
- Testing
- CYP2C9;VKORC1
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangdong Provincial People's Hospital
ESRD, Hemodialysis
The Evaluation of the DIMI RRT System In-Center to Demonstrate Safety and Usability in the Home Environment
This is a prospective, multicenter, open label, non-randomized, cross-over study. Subjects will be enrolled in the trial for approximately 18 weeks and will use the DIMI RRT System for their dialysis treatments for all study…
- Trial name
- NCT04868643
- Testing
- The DIMI Renal Replacement Therapy (RRT) System
- Sponsor
- Dialco Medical Inc.
Hyperuricemia
Lowering Serum Uric Acid to Prevent Acute Kidney Injury
Acute kidney injury is associated with a rise in serum uric acid during cardiovascular surgery and can cause poor blood flow to the kidneys making them vulnerable to kidney injury.
- Trial name
- RasbAKI (NCT00756964)
- Testing
- Rasburicase
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Florida
Akut Kidney Injury, Renal Replacement Therapy for Acute Kidney Injury in ICU
The Role of Renal Resistive Index (RI) in Predicting Acute Kidney Injury Progression in Intensive Care Clinic
Acute kidney injury(AKI) is defined in the KDIGO guidelines as a ≥0.3 mg/dL (≥26.5 micromol/L) increase in serum creatinine in the previous 48 hours or a ≥1.5-fold increase in serum creatinine from baseline, known or presumed to…
- Trial name
- NCT06995222
- Testing
- renal resistive index with Doppler ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Gulhane Training and Research Hospital
Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT)
Ultrasound-Guided Microbubble Removal and Filter Lifespan During CRRT: A Pilot Crossover Study
What is this study about? This study is designed to evaluate whether ultrasound-guided removal of microbubbles during circuit priming in Continuous Renal Replacement Therapy (CRRT) can extend the filter lifespan for critically…
- Conditions
- Acute Kidney Injury, Continuous Renal Replacement Therapy (CRRT), Filter Clotting, Microbubbles
- Trial name
- NCT07005531
- Testing
- Ultrasound-Guided Microbubble Clearance During Circuit Priming
- Volunteers
- 40 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College