Clinical trials: Kidney Transplant; Complications, open to volunteers
Kidney Transplant; Complications, Liver Transplant; Complications
MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation
To define the sensibility and the specificity of increased levels of MR-proADM for early, non-invasive, diagnosis of AR and DGF after kidney and liver transplantation creating a predictive model for related complications after…
- Trial name
- DARE (NCT06130046)
- Testing
- MR-proADM dosage
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Rome Tor Vergata
Transplant Complication, Renal Transplant
NEgative prEssure Wound Therapy in Renal Transplant
This is a prospective study involving patients undergoing open renal transplant. Renal transplant recipients were randomly divided into two groups: the NPWT group, which received NPWT, and the Standard group, which received…
- Conditions
- Transplant Complication, Renal Transplant, Wound Complication
- Trial name
- NEWER (NCT07065734)
- Testing
- NWPT group
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Kidney Transplant; Complications
Evaluaion the Short Term Effects of Advograf Plus Rapamiune After Kidney Transplantation
Cornerstone immunosuppressive therapy currently relies on immediate-release tacrolimus, a calcineurin inhibitor (CNI) that is potentially nephrotoxic and is more diabetogenic than cyclosporine A.
- Trial name
- NCT07033858
- Testing
- Rapamune Pill
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Metabolic Acidosis, Kidney Transplant; Complications
Effect of Alkali Therapy on Vascular and Graft Function in Kidney Transplant Recipients
Lower serum bicarbonate levels, even within the normal laboratory range, in kidney transplant recipients (KTRs) are associated with an increased risk of graft loss, cardiovascular events and mortality.
- Conditions
- Metabolic Acidosis, Kidney Transplant; Complications, Vascular Diseases
- Trial name
- NCT05005793
- Testing
- Sodium bicarbonate
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Kidney Transplant; Complications, Vascular Diseases
Efficacy and Mechanisms of Dapagliflozin in Promoting Kidney Function and Cardiovascular Health in Kidney Transplant Recipients
Long-term allograft function in kidney transplant recipients (KTRs) remain suboptimal, and graft failure causes significant morbidity and mortality, with cardiovascular disease being the leading cause of death in KTRs and the…
- Conditions
- Kidney Transplant; Complications, Vascular Diseases, Diabetes
- Trial name
- NCT06140537
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Kidney Transplant Rejection, Kidney Transplant; Complications
Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients
The renal biopsy (RB) represents the gold-standard for the diagnosis of acute renal transplant rejection (AR), and allows early verification of a so-called "subclinical" rejection, ie without any clinical or biological…
- Trial name
- NCT04702022
- Testing
- 18FDG PET / CT
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Ischemia-reperfusion Injury, Kidney Transplant; Complications
A Trial to Assess Efficacy and Safety of ex Vivo Allograft Admin of iCM012 Solution 2 mg/ml to Improve Its Function in Recipients of DCD Kidneys
Randomized (1:1), placebo controlled, double blind efficacy trial. 200 patients will be followed up for 12 months post transplantation.
- Trial name
- NCT06582485
- Testing
- iCM012 solution 2 mg/mL
- Volunteers
- 200 people
- Sponsor
- iCoat Medical AB
Interstitial Fibrosis, Kidney Transplant; Complications
Fingolimod for the Abrogation of Interstitial Fibrosis and Tubular Atrophy Following Kidney Transplantation
This is a randomized, double-blind, placebo-controlled trial in de novo kidney transplant patients to determine if the addition of fingolimod (brand name Gilenya®, candidate name- FTY720) on the background of standard…
- Conditions
- Interstitial Fibrosis, Kidney Transplant; Complications, Kidney Transplant Rejection, Kidney Transplant Failure and Rejection
- Trial name
- NCT05285878
- Testing
- Fingolimod
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Kidney Transplant; Complications, Bone Loss
Bone Density and Vascular Calcifications Evolution After Renal Transplant
The investigators project is based on: Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA); The non-invasive detection of vascular calcifications (by abdominal CT scanner)…
- Trial name
- NCT04713774
- Testing
- High-resolution peripheral quantitative CT scanner (HRpQCT)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Kidney Transplant; Complications, Diabetes Mellitus
Effect of Empagliflozin vs Linagliptin on Glycemic Outcomes,Renal Outcomes & Body Composition in Renal Transplant Recipients With Diabetes Mellitus
In the early postoperative period, hyperglycemia is frequently seen in renal transplant recipients primarily because of high doses of immunosuppressive therapy. Many of these patients have pre-existing type 2 diabetes (T2D).
- Trial name
- EmLinaRenal (NCT06095492)
- Testing
- Empagliflozin 25 MG, Linagliptin
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Medanta, The Medicity, India
Chronic Kidney Diseases, Atrial Fibrillation
Stroke Prophylaxis With Apixaban in Chronic Kidney Disease Stage 5 Patients With Atrial Fibrillation
Objective: To study the efficacy and safety of apixaban as stroke prophylaxis in patients with chronic kidney disease (CKD) stage 5 and atrial fibrillation (AF) with or without dialysis treatment.
- Conditions
- Chronic Kidney Diseases, Atrial Fibrillation, Stroke, Intracerebral Hemorrhage
- Trial name
- SACK (NCT05679024)
- Testing
- Apixaban 2.5 milligram Oral Tablet
- Where
- 34 sites in Finland, Iceland and 2 more
- Volunteers
- 1,400 people
- Sponsor
- Region Stockholm
Arterial Hypertension, Kidney Transplant; Complications
StOPping Hypertension and imprOving Children's Lives After KidnEy TranSplantation
Cardiovascular (CV) disease is a major morbidity in children after kidney transplantation (KTx), limiting life expectancy and impairing graft function.
- Trial name
- SOPHOCLES (NCT06589947)
- Testing
- Intensified BP control, Standard Treatment
- Volunteers
- 170 people
- Sponsor
- Hannover Medical School
AKI, CKD
Genetics in the Progression of Nephropathies
This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to: AKI CKD Hypertension ADPKD CKD-MBD Patients with decompensated heart failure undergoing either…
- Conditions
- AKI, CKD, Ckd-Mbd, CKD (Chronic Kidney Disease) Stage 5D
- Trial name
- NCT06416761
- Testing
- genetic polymorphisms
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Ospedale San Raffaele
Stem Cell Transplant Complications, Acute Graft Versus Host Disease
Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region.
- Conditions
- Stem Cell Transplant Complications, Acute Graft Versus Host Disease, Acute Kidney Injury, Major Adverse Cardiac Events
- Trial name
- NCT06386445
- Testing
- Serum metabolomics sequencing
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Transplant Complication, Kidney Injury
Spatial Transcriptomics in Kidney Transplantation
The study is an investigator-led, prospective, longitudinal, observational cohort study. The central hypothesis for this study is that spatial data will reveal new insights to immune cell function and local interactions within…
- Trial name
- SPACE-KiT (NCT06288425)
- Testing
- Non interventional
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Western Sydney Local Health District
Kidney Transplant; Complications, Frailty
Effect of Home-based Training Program for Kidney Transplant Recipients (HOMETRAIN-KTR)
Does home-based training work in kidney transplant recipients with reduced physical function? The goal of this clinical trial is to learn if home-based training works to better physical function in adult kidney transplant…
- Conditions
- Kidney Transplant; Complications, Frailty, Physical Disability
- Trial name
- NCT06379009
- Testing
- Training
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Kidney Transplant; Complications, Frailty Syndrome
Comprehensive Geriatric Assessment in Kidney Transplantation
This observational study aims to analyze the results of comprehensive geriatric assessment and to monitor the development of functional status in geriatric kidney transplant candidates and recipients.
- Conditions
- Kidney Transplant; Complications, Frailty Syndrome, Depressive Syndrome
- Trial name
- CoGeriaTx (NCT06104696)
- Testing
- Functional geriatric assessment
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Kidney Transplant; Complications, Dialysis; Complications
Structured Program of Exercise for Recipients of Kidney Transplantation
Older patients with end- stage kidney disease (ESKD) are at very high risk for functional impairment. Kidney transplantation (KT) has the potential to ameliorate the detrimental effects of ESKD on physical activity and functional…
- Conditions
- Kidney Transplant; Complications, Dialysis; Complications, Physical Disability, Frailty Syndrome
- Trial name
- SPaRKT (NCT04954690)
- Testing
- Structured Program of exercise for Recipients of Kidney Transplantation (WC), Structured Program of exercise for Recipients of Kidney Transplantation (WC + CG), Usual Care
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of California, San Francisco