Clinical trials: Kidney Transplant; Complications, open to volunteers
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Transplant Complication, Kidney Transplant Rejection
GEnomic Medicine in Kidney Transplantation Study
Investigator led, prospective, observational cohort study to detect genomic features which can predict outcomes following kidney transplantation. 1.
- Trial name
- GEM-KiT (NCT06365411)
- Testing
- Biomarker discovery and validation - with focus on genomic biomarkers
- Where
- Australia
- Volunteers
- 1,000 people
- Sponsor
- Western Sydney Local Health District
Kidney Failure Chronic, Stem Cell Transplant
Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation
The primary objective is to assess the safety of the addition of venetoclax to reduced intensity conditioning for HLA-matched and haploidentical combined HSC and kidney transplantation as measured by stable full donor…
- Conditions
- Kidney Failure Chronic, Stem Cell Transplant, Stem Cell Transplant Complications, Tolerance
- Trial name
- NCT07358195
- Testing
- Venetoclax, Hematopoietic Cell Transplantation Conditioning Regimen, Kidney Transplant
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Kidney Transplant; Complications, CMV
CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients
The purpose of this study is to study how CMVIG interacts with the body and to see if it might work to prevent kidney transplant patients from becoming infected with CMV.
- Trial name
- NCT07096453
- Testing
- Cytogam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Kidney Failure, Kidney Transplant; Complications
Delayed Tolerance Through Mixed Chimerism
This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor).
- Conditions
- Kidney Failure, Kidney Transplant; Complications, Chimera
- Trial name
- NCT05900401
- Testing
- Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Cytomegalovirus (CMV), Kidney Transplant; Complications
Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients
This is a prospective, randomized multicenter trial of preemptive therapy (PET) vs. antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in adult D+R- kidney transplant recipients (KTR).
- Conditions
- Cytomegalovirus (CMV), Kidney Transplant; Complications, Kidney Diseases
- Trial name
- KPoP (NCT06798909)
- Testing
- Valganciclovir (Pre-emptive CMV Therapy), Valganciclovir CMV Prophylaxis
- Where
- 8 sites in United States
- Volunteers
- 360 people
- Sponsor
- University of California, San Francisco
Liver Transplant; Complications, Renal Insufficiency
Extended-Release Tacrolimus Following Liver Transplantation
Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or…
- Conditions
- Liver Transplant; Complications, Renal Insufficiency, Immunosuppressant Adverse Reaction, Metabolic Syndrome
- Trial name
- NCT05242315
- Testing
- Envarsus Oral Product, Prograf (SOC)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Alberta
BK Virus Infection, Kidney Transplant; Complications
Immune Registry for BK in Kidney Transplant Recipients
Kidney transplantation (KT) is the best treatment modality available to date for patients with advanced kidney disease and the success of KT is dependent on maintaining a selective intricate balance between the risk of rejection…
- Trial name
- NCT06538961
- Testing
- Blood samples: Main Study group, Data Collection, Urine Sample- Main Study group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Kidney Transplant Failure and Rejection, Kidney Transplant; Complications
ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants
This is a phase 1 trial, 36 month duration for subjects with end-stage renal disease (ESRD). The objectives of the trail are1) Determine the safety of ECP-DL cell infusion in living donor renal transplant recipients.
- Trial name
- ECP (NCT07083830)
- Testing
- ECP-DL treated mononuclear cell infusion
- Volunteers
- 24 people
- Sponsor
- Northwestern University
Kidney Transplant; Complications, Surgery
The PROAKTIVE Trial
The PRO-Active rehabilitation prior to Kidney Transplantation to ImproVe patient-centered recovery Evaluation trial tests an approach where people are supported to exercise, improve diet, and receive emotional support at home…
- Trial name
- NCT07696624
- Testing
- Pro-hab program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Ottawa Hospital Research Institute
Urinary Tract Infections, Kidney Transplant; Complications
Double Voiding and Post-transplant UTI
Urinary tract infections (UTI) are common in kidney transplant recipients and are an important cause of illness and hospital admissions.
- Trial name
- NCT05711446
- Testing
- Double Voiding, Regular Voiding
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Weill Medical College of Cornell University
Kidney Transplant; Complications
The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
EFFEKTOR is a vanguard, multicenter, phase 2 randomized, double blinded, placebo controlled clinical trial to determine the feasibility, tolerability, safety, and efficacy of finerenone in kidney transplant recipients (KTRs).
- Trial name
- NCT06059664
- Testing
- Finerenone Oral Tablet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Transplant; Complications, Acute Kidney Injury
Association Between Renal Regional Oxygen Saturation Measured by Near-InfraRed Spectroscopy and Postoperative Renal Failure After Lung Transplantation Surgery: A Pilot Study
Complications after lung transplantation are almost ubiquitous, among which postoperative acute renal failure may represent more than 50% of lung transplant patients and require extrarenal purification in 5 to 13% of cases.
- Trial name
- SO-AKI-TP (NCT05836922)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cardiovascular Diseases, Kidney Transplant; Complications
Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation
Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause…
- Trial name
- CRAFT-CTCA (NCT06234410)
- Testing
- Computed tomography coronary angiography (CTCA)
- Where
- 2 sites in United Kingdom
- Volunteers
- 332 people
- Sponsor
- University of Edinburgh
Kidney Transplant; Complications, Diabetes Mellitus, Type 2
Use of CGM in Kidney Transplant Recipients
The investigators want to study the impact CGM (continuous glucose monitoring) has on patients glycemic control as determined by time in range (TIR 70-180 mg/dL) in the Diabetic Kidney Transplant population.
- Conditions
- Kidney Transplant; Complications, Diabetes Mellitus, Type 2, Insulin Dependent Diabetes
- Trial name
- NCT04783441
- Testing
- Dexcom G6, Dexcom G6 blinded sensor
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, Davis
Hyperglycemia, Renal Transplant Complication Primary Non-Function
Semaglutide Treatment for Hyperglycaemia After Renal Transplantation
Background: Post-transplant hyperglycaemia occurs frequently in renal transplant recipients within the first two weeks after transplantation.
- Conditions
- Hyperglycemia, Renal Transplant Complication Primary Non-Function, Diabetes
- Trial name
- Sema-RTx (NCT05702931)
- Testing
- Semaglutide 14 MG [Rybelsus]
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cytomegalovirus, Organ Transplant
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late CMV disease after a liver…
- Conditions
- Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications, Liver Transplant Complications
- Trial name
- SHIELD (NCT06958796)
- Testing
- Cytomegalovirus Immune Globulin Intravenous (Human) monthly for three months
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Camille N. Kotton, MD
Kidney Transplant; Complications
Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion
The REWARM study is a randomized controlled clinical efficacy study, with primary outcome renal function 12 months after transplantation of kidneys recovered from deceased donors aged 50 years or older.
- Trial name
- REWARM (NCT05782543)
- Testing
- Normothermic machine perfusion
- Where
- 3 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Transplant Complication, Kidney Transplant
"A Privacy-protecting Environment for Child Transplants Health Related and Genomic Data Integration in the European Reference Network"
Protect_Child_101 is an observational study to be performed in children that have undergone a liver or renal transplant. The aim of this study is to analyse small variations in the genetic material (DNA) of transplanted children.
- Conditions
- Transplant Complication, Kidney Transplant, Liver Transplant
- Trial name
- Protect_Child (NCT07194057)
- Testing
- Whole genome sequencing, Polygenic Risk Score Calculation, Methylome and episignatures
- Where
- 4 sites in Germany, Italy and 1 more
- Volunteers
- 200 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Liver Transplant; Complications, AKI - Acute Kidney Injury
The Efficacy of Intravenous Amino Acids in Reducing the Occurrence of AKI After Live Donor Liver Transplant
This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT.
- Trial name
- NCT07132697
- Testing
- L-Amino acid mixture, Standard of care
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India