Clinical trials: Kidney Transplant
Renal Transplantation
Computer Guided Doing of Tacrolimus in Renal Transplantation
Dosing of tacrolimus is challenging due to the large inter-individual variation in its pharmacokinetics. The investigators have developed a pharmacokinetics population model that can be used to estimate individual doses of…
- Trial name
- OPTIMAL (NCT02010320)
- Testing
- Computer dosing, Standard dose determination
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- University of Oslo School of Pharmacy
Secondary Hyperparathyroidism, Tertiary Hyperparathyroidism
Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism
The goal of this pilot clinical is to determine the feasibility of a fully powered clinical trial to determine the effectiveness of intraoperative parathyroid hormone (IOPTH) criteria in guiding surgery for secondary and tertiary…
- Trial name
- PEREGRINE (NCT06542315)
- Testing
- Intraoperative parathyroid hormone (IOPTH) monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Liver Transplantation, Ischaemia Reperfusion Injury
Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation
Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management.
- Conditions
- Liver Transplantation, Ischaemia Reperfusion Injury, Perioperative Complications
- Trial name
- NCT07631689
- Testing
- Reperfusion Blood Discard, Standard Liver Transplantation
- Volunteers
- 132 people
- Sponsor
- University of Sao Paulo General Hospital
Kidney Transplant
Study to Evaluate the Pharmacokinetics and Tolerability of Tacrolimus in Kidney Transplant Recipients.
The purpose of this study is to evaluate the pharmacokinetics and tolerability of Tacrolimus tablet(TacroBell) in kidney transplant recipients.
- Trial name
- PK-TACT (NCT04102943)
- Testing
- tacrolimus tablet, tacrolimus capsules
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Kidney Failure, Chronic, Kidney Transplantation
Drone Transport of Deceased-Donor Kidney Grafts Between Two French Hospitals Before Transplantation: a Pilot Safety Study
Cold ischemia time, the period during which a donated kidney is kept cold outside the body between its removal from the donor and its transplantation into the recipient, is one of the main modifiable factors influencing how…
- Conditions
- Kidney Failure, Chronic, Kidney Transplantation, Delayed Graft Function, Cold Ischemia
- Trial name
- RAfALREIN (NCT07851571)
- Testing
- Kidney graft transport by autonomous unmanned aircraft (drone) between the procurement and transplantation centres
- Volunteers
- 5 people
- Sponsor
- Nantes University Hospital
Kidney Transplant, Rejection
Detection of Circulating Kidney DNA in Kidney Transplant Patients Facing an Episode of Graft Rejection
In France, 3,500 kidney transplants are carried out per year; and 40,000 people succeed in 2019 with a kidney transplant. Despite regular medical monitoring, nearly 30% of transplant patients will develop rejection.
- Trial name
- DART-RREGREF (NCT06351488)
- Where
- 3 sites in France
- Volunteers
- 319 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplantation
Ultra-low Dose Subcutaneous IL-2 in Renal Transplantation
To investigate the safety and tolerability of treatment with low dose rIL-2 in renal transplant recipients. To assess the immunologic impact of low dose rIL-2 in renal transplant recipients.
- Trial name
- NCT02417870
- Testing
- aldesleukin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Anil K. Chandraker, MD
Urinary Tract Infections, Kidney Transplant; Complications
Double Voiding and Post-transplant UTI
Urinary tract infections (UTI) are common in kidney transplant recipients and are an important cause of illness and hospital admissions.
- Trial name
- NCT05711446
- Testing
- Double Voiding, Regular Voiding
- Where
- United States
- Volunteers
- 438 people
- Sponsor
- Weill Medical College of Cornell University
Kidney Rejection Transplant
Omeprazole and Famotidine in Chronic Dysfunction of the Transplanted Kidney
The aim of the study is to compare the effect of omeprazole and famotidine on the risk of developing chronic renal transplant dysfunction.
- Trial name
- NCT05061303
- Testing
- Assessment of the drug concentration in the blood
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- Poznan University of Medical Sciences
Renal Failure
Induction of Donor-Specific Tolerance in Recipients of Live Donor Stem Cell Infusion (Compassionate Use)
Four subjects were treated under compassionate use provisions under this study with facilitating cell therapy (FCRx)
- Trial name
- NCT02051673
- Testing
- Biological/Vaccine: Enriched Hematopoetic Stem Cell Infusion
- Where
- United States
- Sponsor
- Talaris Therapeutics Inc.
Chronic Kidney Disease, Renal Insufficiency
Comparison of Markers of Kidney Function
Glomerular filtration rate (GFR) is the best known measurement of kidney function. Serum creatinine (blood test) is the most commonly used marker to predict GFR.
- Trial name
- NCT01403766
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Los Angeles
Kidney Transplantation, Healthy Lifestyle Behaviors
Determining the Effect of Individualized Education Program in Kidney Transplant Patients
Objective: The aim of this study is to determine the effect of an individualized education program on the development of healthy lifestyle behaviors and the prevention of postoperative cardiometabolic problems in patients…
- Conditions
- Kidney Transplantation, Healthy Lifestyle Behaviors, Metabolic Problems
- Trial name
- NCT06674239
- Testing
- Patient Follow-up and Evaluation Form, Patient Information Form Healthy Lifestyle Behaviors Scale Education Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Chronic Kidney Disease, Kidney Transplant
The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol.
- Conditions
- Chronic Kidney Disease, Kidney Transplant, Coronary Microvascular Dysfunction (CMD), Inflammation
- Trial name
- RESTORE (NCT07222683)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Brigham and Women's Hospital
Graft Rejection
Molecular HistoMx Assessment for Kidney Transplant Rejection and Management
Transcriptomic analysis of kidney biopsies has demonstrated the potential to improve diagnosis of graft rejection. Molecular assessment of kidney graft rejection based on the Banff Human Organ Transplant consensus gene panel is…
- Trial name
- NCT07347353
- Testing
- No intervention
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Kidney Transplant Recipients
Non Invasive Blood Test To Diagnose Acute Rejection After Kidney Transplantation
This is a prospective, multicenter, observational study of kidney transplant subjects where blood specimens, intended for dd-cfDNA and other future research purposes, will be drawn after transplant
- Trial name
- DART (NCT02424227)
- Where
- 14 sites in United States
- Volunteers
- 401 people
- Sponsor
- CareDx
Medication Adherence
Incidence of Non Adherence to Treatment With Once-daily Formulation of Tacrolimus
Aim The primary objective of this study is to compare medication adherence with medical therapy in patients receiving once-daily versus twice-daily tacrolimus regimens.
- Trial name
- Advagraf (NCT02805842)
- Testing
- Tacrolimus BID, Advagraf QD
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Postoperative Complications
Hyperinsulinemic Normoglycemic Clamp for Pancreas and Simultaneous Pancreas/Kidney Transplant Recipients
This study proposes a simple and safe way of lowering this complicate rate, while improving graft recovering and protecting the graft as it recovers from the transplant.
- Trial name
- NCT01001273
- Testing
- Hyperinsulinemic Normoglycemic Clamp
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Kidney Transplant, Kidney Disease, Chronic
KTRSensor Scotland Study: An Observational Study Into Predictors and Diagnosis of Kidney Transplant Rejection
An observational study capturing real world transplant patients in the post-operative setting aiming to further determine the utility of biomarkers to improve outcomes.
- Trial name
- KTRSensors (NCT06830473)
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus；Uremia
Clinical Analysis of Simultaneous Pancreas-kidney Transplantation for End-stage Renal Disease Associated With Diabetes Mellitus
The first pancreas transplantation was performed in 1966, by 2015, more than 40,000 pancreas transplantation have been performed worldwide.
- Trial name
- NCT05497232
- Testing
- simultaneous pancreas-kidney transplantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
End Stage Renal Disease, Hemodialysis Access Failure
PReSeRVE-HD: Observational Study of the Merit HeRO® Graft and Super HeRO® in Patients on Hemodialysis
The goal of this observational study is to increase the understanding of the safety and performance of Merit Medical's HeRO Graft System (HeRO) and Super HeRO Adaptor and Support Seal System (Super HeRO) devices.
- Trial name
- PReSeRVE-HD (NCT06422871)
- Testing
- HeRO® Graft System or Super HeRO® System
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Merit Medical Systems, Inc.