Clinical trials: Kidney Transplant Candidates
Kidney Transplant Recipient Response to Shingrix Vaccine, Kidney Failure
Shingrix in Renal Transplant Recipients
The goal of this clinical trial is to learn how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant, including those who later receive a transplant.
- Conditions
- Kidney Transplant Recipient Response to Shingrix Vaccine, Kidney Failure, Kidney Failure, Chronic, Kidney Transplantation
- Trial name
- NCT04128189
- Testing
- Shingrix
- Where
- 4 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Colorado, Denver
End-stage Renal Disease, Kidney Transplantation
Evaluation of Desensitization Protocols in HLA-incompatible Kidney-transplant Candidates
Kidney transplantation is the best renal-replacement in the setting of end-stage renal disease. However, some transplant candidates have developed anti-HLA alloantibodies (human leukocyte antigen).
- Conditions
- End-stage Renal Disease, Kidney Transplantation, Hla-incompatible Kidney Transplant Candidates
- Trial name
- NCT03507348
- Testing
- visits of tocilizumab injection (every 4 weeks, up to 5 visits), Rituximab 375 mg/m2 at Day-30, Rituximab 375 mg/m2 at Day-15 (only for donors living)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
End Stage Renal Disease, End-Stage Kidney Disease
Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision
The goal of this pilot randomized trial is to learn about shared decision making in kidney transplant candidates. The aim of this proposal is to evaluate the Donor Plan Donor Choice tool to promote high-quality Shared Decision…
- Conditions
- End Stage Renal Disease, End-Stage Kidney Disease, Kidney Transplantation, Esrd
- Trial name
- NCT05879302
- Testing
- Kidney Offer Shared Decision Making
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hennepin Healthcare Research Institute
Chronic Kidney Disease Stage 5, Periodontal Disease
Response to Periodontal Therapy in a Chronic Kidney Disease Population
This study will evaluate periodontal and systemic parameters of a cohort of chronic kidney disease (stage 5) patients, before and three months after non-surgical periodontal treatment. It does not consider a control group.
- Trial name
- NCT03525457
- Testing
- Non Surgical Periodontal Therapy
- Where
- Chile
- Volunteers
- 65 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Kidney Transplant Candidates
Imlifidase in Living Donor Renal Transplantation Highly Sensitized Recipients
This is a Phase II, pilot, prospective, unicentric trial, to evaluate Imlifidase could improve the transplantability of the highly sensitized patients with good outcomes respect to survival and functionality of the graft.
- Trial name
- LIVEDES (NCT06461546)
- Testing
- Imlifidase
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Diabetes, Type 1
Hybrid Closed-Loop Insulin Delivery System in Type 1 Diabetes Candidates for a Living Donor Kidney Transplant
The investigators' primary aim is to determine the impact of using hybrid closed-loop (HCL) system in patients with type 1 diabetes (T1D) and end stage renal disease (ESRD) prior to kidney transplantation.
- Trial name
- NCT03494010
- Testing
- Observation
- Where
- United States
- Sponsor
- Yale University
Kidney Transplant Candidates
Increasing Communication About Live Donor Kidney Transplant
This study will test the efficacy of a communication intervention intended to increase and improve kidney transplant candidates' communication about live donor kidney transplantation.
- Trial name
- NCT01855438
- Testing
- Living Donor Transplant Education
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Virginia Commonwealth University
Prehabilitation, Kidney Transplant Candidates
PREhabilitation of Candidates for REnal Transplantation
In this study a personalized, multi modal prehabilitation intervention will be offered to n = 64 patients on the kidney transplant waiting-list. The control group (n = 64) will receive care as usual.
- Conditions
- Prehabilitation, Kidney Transplant Candidates, Frailty
- Trial name
- PreCareTx (NCT05489432)
- Testing
- Exercise
- Where
- Netherlands
- Volunteers
- 128 people
- Sponsor
- University Medical Center Groningen
Kidney Transplant, Frailty
Exercise to Treat Frailty and Decreased Physical Function in Transplant Candidates
Frailty is a condition characterized by slowness, weakness, low physical activity, wasting, and exhaustion. Frailty increases the risk for adverse outcomes following transplant such as increased length of stay in the hospital…
- Trial name
- NCT03535584
- Testing
- Exercise Program
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Hepatorenal Syndrome
Terlipressin for HRS-AKI in Liver Transplant Candidates (INFUSE)
Hepatorenal syndrome-acute kidney injury (HRS-AKI), a potentially reversible renal failure, is a serious, rapidly progressing, often fatal, complication of decompensated cirrhosis.
- Trial name
- INFUSE (NCT04460560)
- Testing
- Terlipressin
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
HHV8, HHV8 Infection
HHV8 and Solid Organ Transplantation
Solid organ transplant candidates will undergo serological screening for HHV8 at time of listing and transplantation. In the event of a recipient/donor mismatch R-/D+ or in the presence of a seropositive recipient (R+), blood…
- Conditions
- HHV8, HHV8 Infection, HHV8-Related Malignant Neoplasm, Kaposi Sarcoma
- Trial name
- NCT05081141
- Testing
- Diagnostic test for HHV8 exposure
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Kidney Transplantation
Evaluation of 2 Techniques of Apheresis to Desensitize ABO Incompatible Kidney Transplant Candidates
Kidney transplantation is the treatment of choice for end-stage renal disease. ABO incompatible (ABOi) living donor kidney transplantation is one of the best ways to expand the donors' pool.
- Trial name
- DADI (NCT03477656)
- Testing
- Large volume specific immunoadsorption, Double Filtration Plasmapheresis
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Highly Sensitized Patients on Waiting List for Kidney Transplantation
Safety and Tolerability of Inebilizumab, VIB4920, or the Combination in Highly Sensitized Candidates Awaiting Kidney Transplantation From a Deceased Donor
Viela Bio is conducting an open-label, randomized study of inebilizumab, VIB4920, or the combination as part of a multi-center study in highly sensitized patients on the deceased donor waiting list for kidney transplantation.
- Trial name
- NCT04174677
- Testing
- Inebilizumab, VIB4920, Inebilzumab+VIB4920
- Where
- 2 sites in United States
- Sponsor
- Amgen
Kidney Transplantation
The Impact of Velcade(TM)on Antibody Secreting Cells in Sensitized Renal Allograft Candidates
Patients planning to have kidney transplantation who are sensitized to their donors have high levels of donor specific alloantibodies.
- Trial name
- NCT00722722
- Testing
- Bortezomib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Chronic Kidney Diseases, Hyperparathyroidism, Secondary
Analysis of Bone Microarchitecture With HR-pQCT of Patients With Chronic Kidney Disease (CKD) Candidates for Renal Transplantation
While the duration of renal transplant function has increased over the last decade kidney transplanted patients (KTP) still exhibit a fracture risk 4 times higher than in the general population.
- Trial name
- TRANSBONE (NCT02523209)
- Testing
- HR-pQCT, DEXA
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Kidney Transplant
Social Support Counseling Intervention for Kidney Transplant Candidates
Virtual Coaching for Potential Kidney Transplant Patients
- Trial name
- JtT (NCT06147076)
- Testing
- Social Support Network Counseling Intervention
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Hennepin Healthcare Research Institute
Coronary Artery Disease, Computed Tomography
Diagnostic Performance of Coronary CT Angiography With CT FFR in Kidney Transplantation Candidates
Patients with chronic kidney disease (CKD) before kidney transplantation require that obstructive coronary artery disease (CAD) is excluded, as cardiovascular complications are the leading cause of mortality in kidney transplant…
- Trial name
- NCT03248674
- Testing
- CT FFR
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Stanford University
Frailty, Kidney Transplant; Complications
Frailty Assessment Among Kidney Transplant Candidates
Frailty is common among chronic kidney disease patients who are on the kidney transplant (KT) waiting list. The aim of this study is to assess frailty according to different frailty tools among KT candidates and to establish…
- Trial name
- Mar-Kid (NCT04811417)
- Volunteers
- 500 people
- Sponsor
- Parc de Salut Mar
Physical Disability
Virtually Supervised Exercise for Kidney Transplant Candidates
This study is examining whether a virtually supervised exercise program can improve physical function in persons who are awaiting kidney transplant.
- Trial name
- NCT05355545
- Testing
- Virtually supervised exercise, Health education
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Stanford University