Clinical trials: Kidney Transplant Infection
Kidney Transplant Rejection, Kidney Transplant Failure
Protocol Biopsies in High-risk Renal Transplant Recipients
The present study aims to evaluate the usefulness of protocol biopsies in a cohort of renal transplant patients of high immunological risk for graft injury and loss.
- Conditions
- Kidney Transplant Rejection, Kidney Transplant Failure, Kidney Transplant Infection, Kidney Transplant Failure and Rejection
- Trial name
- NCT04154267
- Testing
- Percutaneous renal biopsy.
- Where
- Brazil
- Volunteers
- 119 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Epstein-Barr Virus Infections
Evaluation of the Efficacy of a Treatment by One Single Dose of Rituximab (375mg/m2 ) in the Prevention of the Epstein Barr Virus (EBV) Primary Infection and Post-transplant Lymphoproliferative Disorder in Adult EBV Seronegative Patients Who Received an EBV Seropositive Kidney Allograft
Epstein Barr virus infects over 90% of human population and persists during lifetime. After infecting B lymphocytes, EBV remains latent in memory B cells.
- Trial name
- REPLY (NCT04989491)
- Testing
- Rituximab, control group
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Strasbourg, France
BK Virus Infection, Kidney Transplant; Complications
Immune Registry for BK in Kidney Transplant Recipients
Kidney transplantation (KT) is the best treatment modality available to date for patients with advanced kidney disease and the success of KT is dependent on maintaining a selective intricate balance between the risk of rejection…
- Trial name
- NCT06538961
- Testing
- Blood samples: Main Study group, Data Collection, Urine Sample- Main Study group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Chronic Myeloproliferative Disorders
Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon
RATIONALE: Beclomethasone may be an effective treatment for graft-versus-host disease. PURPOSE: Phase I/II trial to study the effectiveness of beclomethasone in treating patients who have graft-versus-host disease of the…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00010283
- Testing
- beclomethasone dipropionate
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Covid19, AKI
Global Assessment of Acute and Chronic Kidney Disease Incidence and Outcomes in Patients With COVID-19 Infection
The coronavirus (COVID-19) pandemic has created a significant strain on health care resources across the world for managing critically ill patients.
- Conditions
- Covid19, AKI, CKD, ESRD
- Trial name
- NCT04491227
- Where
- 12 sites in United States, Bolivia and 4 more
- Volunteers
- 2,000 people
- Sponsor
- University of California, San Diego
End-stage Kidney Disease
Optimizing Kidney Transplant Informed Consent
The objective of this study is to evaluate kidney transplant candidates' comprehension about increased risk donor kidneys necessary for informed consent.
- Trial name
- NCT01859884
- Testing
- Inform Me: web-based education tool
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Northwestern University
Infection in Solid Organ Transplant Recipients
Natural History of Cytomegalovirus (CMV) Infection and Disease Among Renal Transplant Recipients
Although the accumulated knowledge regarding Cytomegalovirus (CMV) infection increased substantially over the past years, several issues still deserve further investigation.
- Trial name
- NCT01833416
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Helio Tedesco Silva Junior
Kidney Transplantation, Cytomegalovirus Infections
Pharmacokinetic Parameters of Innovative Valganciclovir Versus Generic Valganciclovir
Cytomegalovirus (CMV) is the most common opportunistic viral pathogen in solid organ transplant receptors (SOTR). In Mexico, the experience using generic immunosuppressants have been demonstrated a wide variation in the…
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, Pharmacokinetics, Therapeutic Equivalency
- Trial name
- NCT03631316
- Testing
- Generic Valganciclovir, Innovative Valganciclovir
- Where
- Mexico
- Volunteers
- 8 people
- Sponsor
- Luis Eduardo Morales Buenrostro
Renal Transplant Recipient, Immunized Against the Cytomegalovirus
Assessing the Risk of CMV Infection of the Renal Transplant About R + by Cellular Immunity Analyzed by the QuantiFERON ®-CMV Test.
Cytomegalovirus (CMV) infection was observed in over 30% of organ recipients with high morbidity. Moreover, no prophylaxis, 75% R + D-transplanted, 55%, R + D + and D-25% R + develop CMV.
- Trial name
- QUANTIC-R+ (NCT02064699)
- Testing
- CMV Infection
- Where
- 12 sites in France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Chronic Hepatitis C-virus Infection, Renal Transplantation
Hepatitis C in Renal Transplant Recipients
The aim of the present trial is to evaluate whether the conversion of immunosuppression from tacrolimus to cyclosporine A induces changes in (i) hepatitis C-virus load, (ii) parameters of hepatic function and (iii) parameters of…
- Trial name
- NCT02108301
- Testing
- tacrolimus-cyclosporine A
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Prof. Dr. Alice Schmidt
HIV-1 Infection, Chronic Renal Insufficiency
Renal Transplantation and Raltegravir in HIV-Infected Patients
The aim of this study is to evaluate the incidence of acute renal graft rejection 6 months after transplantation in HIV-infected patients under three antiretroviral drugs regimen including Raltegravir.
- Trial name
- ANRS153TREVE (NCT01453192)
- Testing
- Raltegravir
- Where
- 14 sites in France
- Volunteers
- 27 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Kidney Transplantation, CMV Infection
Association of T Gamma Delta-CD16+ Cells and Anti-CMV Immunoglobulins in the Prevention of CMV Infection
CMV infection in transplantation remains the most frequent infectious complication causing increased morbidity and mortality. International recommendations advocate prevention of this infection by instituting direct antiviral…
- Trial name
- SYNTAGME (NCT04934527)
- Testing
- Cytotect
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Chronic Disease, Immunocompromised
Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
- Conditions
- Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease
- Trial name
- AMBU-VAX (NCT07391046)
- Testing
- Hospital-Based Vaccination Pathway
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Kidney Transplant Infection, BK Virus Infection
Prediction of BK Virus Reactivation in Kidney Transplant Recipient
There has been no effective predicting tool to accurately predict BKV reactivation after kidney transplantation. The aim is to elucidate the use of flow cytometric analysis for both intracellular cytokines and surface activation…
- Conditions
- Kidney Transplant Infection, BK Virus Infection, BK Virus Nephropathy
- Trial name
- NCT06219616
- Testing
- BKV immune monitoring
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Disorder Related to Renal Transplantation, Immunosuppression Related Infectious Disease
Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal Transplant
Polyomavirus BK nephropathy is a serious complication after renal transplantation leading to graft loss in 40% of cases. Since no virustatic drug exists, the investigators want to study the best way to manage viral invasion by…
- Conditions
- Disorder Related to Renal Transplantation, Immunosuppression Related Infectious Disease, Virus Diseases
- Trial name
- BKVIRUS (NCT01289301)
- Testing
- mTOR inhibitor (everolimus), cyclosporine or tacrolimus
- Where
- 4 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Hannover Medical School
Kidney Transplantation, Cytomegalovirus Infections, EBV Infection
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients.
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, EBV Infection, Antiviral Prophylaxis
- Trial name
- NCT07294547
- Testing
- Valacyclovir (Valtrex), Valganciclovir (Valcyte)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Cytomegalovirus (CMV)
A Study of Cytomegalovirus (CMV) Infection After Kidney Transplant in Adults in the United Kingdom
This observational study intends to retrospectively gather information on cytomegalovirus (CMV) infection management in the United Kingdom (UK) over a period of 7 years (2017-2024).
- Trial name
- NCT06568055
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- Takeda
Kidney Transplant Infection
Study of Pulmonary Infections (Pneumonia) in Kidney Transplant Recipients Admitted to Hospital
The investigators aimed to identify prognosis factors associated with in-hospital complications and assess the epidemiology, management, and outcomes of community-acquired pneumonia in a kidney transplant recipients' cohort.
- Trial name
- NCT05142748
- Where
- France
- Volunteers
- 132 people
- Sponsor
- CHU de Reims
Kidney Transplant Infection
Effects of a Food Supplement in the Prevention of Urinary Tract Infections in Kidney Transplant Patients.
The incidence of Urinary tract infections (UTIs) is very high in kidney transplant patients. Most UTIs occur during the first six months (82% within the first three months) of kidney transplantation and are frequently recurrent.
- Trial name
- MANOTRAS (NCT05109455)
- Testing
- MANOSAR®, Proanthocyanidins
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Arafarma Group, S.A.