Clinical trials: Kidney Transplant Recipient
Kidney Transplant, Renal Transplant Failure
Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Recipients
The purpose of this study is to assess a new test to detect antibodies which may form following kidney transplant. These antibodies can be difficult to detect as they do not cause any symptoms but can lead to kidney damage.
- Conditions
- Kidney Transplant, Renal Transplant Failure, Kidney Transplant Rejection, Frailty
- Trial name
- HLA-AB (NCT06025240)
- Testing
- cf-DNA, Immunological Events following renal transplant in older age, Determining Predictive Models for Post-transplant HLA-specific Antibody Formation
- Where
- United Kingdom
- Volunteers
- 282 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Renal Transplant Recipients, Elderly Patients
RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients
Open label, randomized, multicenter, intervention trial comparing standard immunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen in combination with everolimus.
- Conditions
- Renal Transplant Recipients, Elderly Patients, Immunosuppression
- Trial name
- OPTIMIZE (NCT03797196)
- Testing
- low dose tacrolimus in combination with everolimus, standard dose tacrolimus with mycophenolate mofetil
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 374 people
- Sponsor
- University Medical Center Groningen
Kidney Transplantation, Primary Focal Segmental Glomerulosclerosis (FSGS)
Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients
The purpose of this study was to assess the efficacy of the bleselumab regimen (basiliximab induction, tacrolimus, steroids and bleselumab) compared with the Standard of Care (SOC) regimen (basiliximab induction, tacrolimus…
- Trial name
- NCT02921789
- Testing
- Bleselumab, Basiliximab, Mycophenolate Mofetil (MMF)
- Where
- 23 sites in United States, Canada
- Volunteers
- 67 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Unspecified Complications of Kidney Transplant, Disorder Related to Renal Transplantation
Evaluation of Sun Protection Education for Kidney Transplant Recipients
This study is being done to evaluate the effectiveness of a Sun Protection Strategies workbook for kidney transplant recipients.
- Trial name
- NCT01844713
- Testing
- Workbook
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Northwestern University
Proteinuria, Transplant Glomerulopathy
Acthar as Rescue Therapy for Transplant Glomerulopathy in Kidney Transplant Recipients
The goal of this study is to evaluate the benefit of ACTH (Acthar) in reducing proteinuria associated with transplant glomerulopathy in non-diabetic kidney transplant recipients.
- Trial name
- NCT02057523
- Testing
- Acthar
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Illinois at Chicago
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Chronic Kidney Disease
Reduced Calorie Diet Intervention in Kidney Transplant Recipients
The purpose of this study is to measure the effect of a reduced calorie diet intervention in new kidney transplant recipients on the outcomes weight gain, oxidative stress, and insulin resistance.
- Trial name
- NCT00994838
- Testing
- reduced calorie diet
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Vanderbilt University
Antibody Mediated Rejection
Safety & Efficacy of Eculizumab to Prevent AMR in Living Donor Kidney Transplant Recipients Requiring Desensitization
The purpose of this trial was to determine the safety and efficacy of eculizumab in the prevention of antibody-mediated rejection (AMR) in sensitized recipients of a living donor kidney transplant requiring desensitization…
- Trial name
- NCT01399593
- Testing
- Eculizumab
- Where
- 41 sites in United States, Australia and 8 more
- Volunteers
- 102 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Graft Rejection, Kidney Transplant
Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients
This study will look at the effect on long-term kidney function using tacrolimus right after a transplant and then switching to sirolimus at 3 to 5 months after the transplant.
- Conditions
- Graft Rejection, Kidney Transplant, Renal Allograft Recipients, Renal Transplant
- Trial name
- NCT00895583
- Testing
- Tacrolimus, Sirolimus
- Where
- 44 sites in United States, Argentina and 5 more
- Volunteers
- 254 people
- Sponsor
- Pfizer
Cytomegalovirus Disease
Cut Off for the Diagnosis of Cytomegalovirus (CMV) Disease in Serum-positive Kidney Transplant Recipients
CMV disease is a challenge to the success of renal transplantation. Recently, the investigators analyzed data from 792 renal transplant recipients performed at our hospital between 1999 and 2005.
- Trial name
- NCT01573039
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Hyperglycaemia, Kidney Transplantation
Continuous Glucose Monitoring (CGM) After Kidney Transplantation
This study examines glucose levels measured by continuous glucose monitoring (CGM) in the immediate period following kidney transplantation among recipients with diabetes, without diabetes, and with pre-diabetes.
- Trial name
- CGM-KTx (NCT06675903)
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- Bo Feldt-Rasmussen
Periodontitis, Kidney Transplant Recipients
Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients
This randomized controlled trial evaluates the efficacy of diode laser-assisted non-surgical periodontal therapy in kidney transplant recipients with periodontitis.
- Trial name
- KTRs (NCT07532694)
- Testing
- Scaling and Root Planing, Diode Laser
- Where
- 2 sites in Vietnam
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Military Hospital 103
Proteinuria
Oral Paricalcitol in Renal Transplant Recipients for Reducing Albuminuria
The main objective of this study is to examine if paricalcitol may reduce progression of graft fibrosis and proteinuria in kidney transplant patients.
- Trial name
- NCT01694160
- Testing
- Paricalcitol
- Where
- Norway
- Volunteers
- 77 people
- Sponsor
- Oslo University Hospital
Kidney Transplantation, Renal Transplant Recipients
Selective CD28 Blockade in Renal Transplant Recipients
The aim of this study is to evaluate the safety and efficacy of lulizumab, a CD28-specific domain antibody (CD28 dAb), compared to tacrolimus, as the primary immunosuppressant in first-time renal transplant recipients.
- Trial name
- NCT04903054
- Testing
- Lulizumab, Tacrolimus, Thymoglobulin®
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Transplant, Cardiovascular Disease
Randomized Trial of SGLT2i in Heart Transplant Recipients
Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival.
- Conditions
- Heart Transplant, Cardiovascular Disease, Kidney Disease
- Trial name
- NCT06625073
- Testing
- Empagliflozin
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- VA Office of Research and Development
End-Stage Renal Disease
Evaluation of a Patient Navigation System to Reduce Time to Waitlisting for Potential Kidney Transplant Recipients
The purpose of this study is to measure the effect of introducing a patient navigator to guide high and moderate risk patients through the pre-waitlisting phases of the kidney transplant process.
- Trial name
- NCT01776073
- Testing
- Patient Navigation
- Where
- United States
- Volunteers
- 401 people
- Sponsor
- Emory University
Transplant Recipient (Kidney), Steroid-Free Maintenance Immunosuppression
Studies of Kidney Transplant Outcome
The purpose of this study is to improve outcome for kidney transplant recipients. There has not been commensurate improvement in medium and long-term outcomes. Ongoing clinical research is necessary to improve transplant outcomes.
- Conditions
- Transplant Recipient (Kidney), Steroid-Free Maintenance Immunosuppression, Post-Transplant Infections, Thymoglobulin
- Trial name
- NCT01277770
- Testing
- Steroid-Free Maintenance Immunosuppression, Infection After Kidney Transplantation, Evaluation of the DGF nomogram in Thymoglobulin
- Where
- United States
- Volunteers
- 7,500 people
- Sponsor
- University of Minnesota
End-Stage Renal Disease
Study on the Safety and Efficacy of a Time-of-Day-Based Individualized Tacrolimus Dosing Regimen in Kidney Transplant Recipients
The goal of this clinical trial is to evaluate whether chronopharmacokinetic model-guided individualized unequal twice-daily tacrolimus dosing improves renal allograft function and reduces acute rejection in stable kidney…
- Trial name
- NCT07877103
- Testing
- Chronotherapy-based individualized low-morning high-evening tacrolimus dosing, conventional dosing regimen
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
End-Stage Renal Disease
Belatacept in Renal Transplantation With Intermediate Risk Maryland Aggregate Pathology Index (MAPI) Scores
This will be a pilot study to investigate the use of belatacept (BMS) therapy in kidney transplant patients who have a MAPI score of greater than or equal to 8.
- Trial name
- NCT01496417
- Testing
- Belatacept
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland
Kidney Transplant Rejection
ddcfDNA in Kidney Transplant Recipients
The objective of this study is to predict subclinical Antibody-Mediated Rejection (ABMR) occurrences in de novo DSA-positive recipients maintaining stable renal function after transplantation.
- Trial name
- NCT06013358
- Testing
- AlloSeq cfDNA
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Seoul National University Hospital