Clinical trials: Kidney Transplant Recipients, active
Kidney Transplant Infection, Bloodstream Infection
Prediction and Prevention of Bloodstream Infections After Kidney Transplantation
Kidney transplant recipients take medicines that suppress the immune system to prevent rejection of the transplanted kidney. As a result, they have a high risk of infections, especially urinary tract infections (UTIs).
- Conditions
- Kidney Transplant Infection, Bloodstream Infection, Kidney Transplant, Kidney Transplant Recipients
- Trial name
- PREDICT (NCT07407673)
- Testing
- Pivmecillinam
- Where
- 3 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Susanne Dam Nielsen, MD, DMSc
Kidney Transplant Recipient, Kidney Transplant; Complications
Vascular Complications After Kidney Transplantation
To determine the incidence of arterial inflow problems and venous outflow problems as causes of impaired renal function and/or treatment-resistant hypertension after kidney transplantation, when all kidney-transplant recipients…
- Conditions
- Kidney Transplant Recipient, Kidney Transplant; Complications, Transplant Renal Artery Stenosis, Renovascular Disease
- Trial name
- DAN-PTRAIII (NCT07531966)
- Testing
- Catheter-based angiography, Measurement of translesional pressure gradients, Intravascular ultrasound (IVUS)
- Where
- 3 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Kidney Transplant Recipient, Cutaneous Squamous Cell Carcinoma (CSCC)
Cemiplimab for Kidney Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma
This is a phase II, multicenter, open label, single arm, non-randomized trial using Simon's optimal two-stage design to evaluate the efficacy of cemiplimab in kidney transplant recipients with advanced cutaneous squamous cell…
- Conditions
- Kidney Transplant Recipient, Cutaneous Squamous Cell Carcinoma (CSCC), Advanced Cutaneous Squamous Cell Carcinoma, Kidney Transplant
- Trial name
- CONTRAC-2 (NCT07715734)
- Testing
- Cemiplimab, Prednisone, Sirolimus
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Kidney Failure, Transplant Recipient (Kidney)
Tolerance Through Mixed Chimerism (Sip-Tego)
This is an open-label, single-institution study to assess the safety and the efficacy of the Sip-Tego regimen for the induction of donor-specific immunologic unresponsiveness to a renal allograft.
- Conditions
- Kidney Failure, Transplant Recipient (Kidney), Transplant Tolerance, Immunosuppresion
- Trial name
- NCT06972069
- Testing
- Combined Kidney/Bone Marrow Transplant, Donation of Kidney / Bone Marrow, Conditioning Regimen (Rituxan, Siplizumab (or ATGAM), Cyclophosphamide, Tegoprubart)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tatsuo Kawai, MD, PhD
Kidney Transplant, Transplant Recipients
AI-Assisted vs Usual Follow-up in Kidney Transplantation
The goal of this clinical trial is to learn whether kidney transplant follow-up visits run by a health professional using an artificial intelligence (AI) computer helper are as good as usual follow-up visits with a doctor.
- Trial name
- FOLLOW-KTx (NCT07842289)
- Testing
- AI-Assisted Follow-up Consultation, Usual Physician-Led Follow-up Consultation
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Kidney Transplant Recipient
Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus
The study aims to determine the short-term efficacy, mechanisms and safety of 24 weeks of semaglutide therapy in 37 KTR at risk of post-transplant diabetes mellitus (PTDM).
- Trial name
- SPOT-DM (NCT06913023)
- Testing
- Semaglutide 0.25 mg, Semaglutide 0.5 mg, Semaglutide 1.0 mg
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- University Health Network, Toronto
Transplant Recipient (Kidney)
Immune Monitoring-Guided Individualized Tacrolimus Therapy in Renal Transplant Recipients: An Observational Study and PK/PD Modeling
This study aims to resolve the clinical limitation that therapeutic drug monitoring (TDM) alone cannot accurately reflect the net immune status after kidney transplantation.
- Trial name
- NCT07815938
- Testing
- No interventional treatment, only observational data collection without clinical drug adjustment
- Volunteers
- 50 people
- Sponsor
- Zhongnan Hospital
Kidney Transplant Recipient
Biomarker-Guided Mycophenolate Mofetil Elimination in Low-Risk Older Adult Kidney Transplant Recipients
Most kidney transplant recipients take a combination of anti-rejection medicines for the rest of their life. One of these is called mycophenolate mofetil (MMF), also known by the brand name CellCept.
- Trial name
- OPTIMA-KT (NCT07806136)
- Testing
- Tacrolimus (Kidney transplant maintenance immunosuppression), Mycophenoate Mofetil, Prednisone (SOC arm)
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Chronic Kidney Disease, Autoimmune Diseases
Capillary Sampling in Clinical Populations Undergoing Monitoring
Many people with long-term health conditions require regular blood tests to monitor their disease or medications. These blood tests are usually performed by taking blood from a vein during a hospital or clinic appointment.
- Conditions
- Chronic Kidney Disease, Autoimmune Diseases, Solid Organ Transplant Recipients
- Trial name
- CAPSICUM (NCT07802665)
- Testing
- Blood sampling with capillary sampling device(s)
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Kidney Disease, Kidney Transplant
A Multicenter, Prospective Blood Collection Study in a Kidney Transplant Population
The purpose of this research is to collect blood samples and data from kidney transplant patients. The samples and data will be used for research and development of non-invasive test to detect donor-derived cell-free DNA…
- Conditions
- Kidney Disease, Kidney Transplant, Transplant Recipient, Renal Function
- Trial name
- Accept cfDNA (NCT07006831)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Devyser Inc.
Sepsis and Septic Shock, Acute Respiratory Failure
Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022.
- Conditions
- Sepsis and Septic Shock, Acute Respiratory Failure, Kidney Transplant Recipients, Immunosuppressive Agents
- Trial name
- REDIS (NCT06881927)
- Testing
- Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression
- Where
- France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Strasbourg, France
Transplant Recipient (Kidney)
Study on Precision Dosing Strategies of Anti-infective Agents in the Very Early Stage of Kidney Transplantation
This study addresses the clinical problem that reliance on serum creatinine, eGFR or empirical dosing fails to accurately adjust anti-infective doses given rapid renal function shifts within the very early 0-5 days post kidney…
- Trial name
- NCT07765615
- Volunteers
- 40 people
- Sponsor
- Zhongnan Hospital
Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors
SGLT2i Effect on PTDM Development and Kidney Allograft Function in Non-diabetic Kidney Transplant Recipients: A Randomized, Doubleblind, Placebo Controlled, National Multicenter Trial
The goal of this clinical trial is to find out whether 12 months of treatment with the SGLT2 inhibitor Forxiga® (dapagliflozin 10 mg once daily), compared with placebo, can reduce the risk of developing post-transplant diabetes…
- Conditions
- Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors, Non-Diabetic Patients, Randomized Controlled Trial (RCT)
- Trial name
- SGL-TX-PTDM (NCT07682350)
- Testing
- SGLT2i
- Where
- 3 sites in Denmark
- Volunteers
- 184 people
- Sponsor
- Odense University Hospital
Kidney Transplant Recipients, Old Age
Neurocognitive Function Changes With Extended-Release Tacrolimus Among Older Kidney Transplant Recipients
The objective of this randomized controlled study is to assess the neurocognitive outcomes between individuals using immediate-release (IR) tacrolimus (Prograf®) and those who were converted to extended-release tacrolimus…
- Trial name
- Neuro-KTR (NCT06751992)
- Testing
- Conversion to extended-release tacrolimus, Maintenance of immediate-release tacrolimus
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Massachusetts General Hospital
Kidney Transplant, Renal Transplant Recipients
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients.
- Trial name
- RTB-006 (NCT03726307)
- Testing
- DCreg: 0.5 million cells/kg+SOC, DCreg: 1.2 million cells/kg+SOC, DCreg:2.5 to 5.0 million cells/kg+SOC
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Angus W. Thomson PhD DSc
Kidney Transplant Recipients
The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
The study aims to determine the short-term efficacy, mechanisms and safety of 12 weeks of dapagliflozin and semaglutide combination therapy in 20 KTR, with and without T2D.
- Trial name
- HALLMARK (NCT05938712)
- Testing
- Dapagliflozin 10 MG, Semaglutide, 1.0 mg/mL
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Periodontitis, Kidney Transplant Recipients
Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients
This randomized controlled trial evaluates the efficacy of diode laser-assisted non-surgical periodontal therapy in kidney transplant recipients with periodontitis.
- Trial name
- KTRs (NCT07532694)
- Testing
- Scaling and Root Planing, Diode Laser
- Where
- 2 sites in Vietnam
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Military Hospital 103
Kidney Transplant Recipient Response to Shingrix Vaccine, Kidney Failure
Shingrix in Renal Transplant Recipients
The goal of this clinical trial is to learn how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant, including those who later receive a transplant.
- Conditions
- Kidney Transplant Recipient Response to Shingrix Vaccine, Kidney Failure, Kidney Failure, Chronic, Kidney Transplantation
- Trial name
- NCT04128189
- Testing
- Shingrix
- Where
- 4 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Colorado, Denver
Highly Sensitized Prospective Kidney Transplant Recipients
Carfilzomib and Belatacept for Desensitization
Some kidney transplant candidates have a very low chance of getting a kidney transplant because their immune systems are "highly sensitized" to most kidney donors.
- Trial name
- ADAPT (NCT05017545)
- Testing
- carfilzomib, belatacept, Bone marrow aspiration
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus (CMV) Infection, Kidney Transplant Recipient
Renal Ex Vivo SYN002 Perfusion to Eliminate CMV Transmission
Donor organs often carry latent Cytomegalovirus (CMV) infection that may be transmitted to the recipient. The goal of this clinical trial is to determine the safety of SYN002 treatment during Ex-Vivo Organ Perfusion (EVOP) in…
- Trial name
- RESPECT-CMV (NCT07488481)
- Testing
- SYN002
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto