Clinical trials: Kidney Transplant Tolerance
Kidney Transplant Tolerance
Kidney Graft Tolerance KTOL
Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor.
- Trial name
- KTOL (NCT06271343)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Nantes University Hospital
Kidney Transplant Rejection
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants
The primary objective of this study is to demonstrate the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living…
- Trial name
- NCT03363945
- Testing
- MDR-101
- Where
- 19 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Medeor Therapeutics, Inc.
Graft Rejection, Kidney Disease
Effectiveness of the Investigational Drug Campath-1H in Preventing Rejection of Transplanted Kidneys
This protocol will test a humanized monoclonal antibody known as Campath-1H for its ability to induce a state of permanent allograft acceptance, or tolerance, when administered in combination with a brief course of the…
- Trial name
- NCT00001984
- Testing
- Alemtuzumab and DSG
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
End Stage Renal Disease
Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease
This pilot study of combined kidney and hematopoietic stem cell transplantation attempts to establish a protocol to induce immunological tolerance as a new strategy to prevent renal graft rejection.
- Trial name
- NCT02176434
- Testing
- Kidney and hematopoietic stem cell transplantation, hematopoietic stem cell
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- University of Zurich
Renal Insufficiency, Chronic, Graft Occlusion, Vascular
External Ionizing Radiation to Prevent Restenosis on Haemodialysis Vascular Access
Although ionizing radiations have been proposed for the prevention of intimal hyperplasia in coronary and peripheral arteries, information is lacking on how irradiation may prevent neointimal smooth-muscle cell proliferation and…
- Conditions
- Renal Insufficiency, Chronic, Graft Occlusion, Vascular, Thrombosis, Intimal Hyperplasia
- Trial name
- RASTA (NCT00379366)
- Testing
- External ionizing radiations
- Where
- 5 sites in France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Bordeaux
Kidney Transplantation
Study Comparing the Safety of BG9588 (Anti-CD40L Antibody) Against Standard Treatment in Kidney Transplantation
The most common problem following a kidney transplant is the development of acute or chronic rejection. Rejection is the immunologic reaction in which the body refuses to accept the transplanted organ.
- Trial name
- NCT00001857
- Testing
- BG9588
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Failure, Kidney Transplant; Complications
Delayed Tolerance Through Mixed Chimerism
This study will examine the safety and effectiveness of a bone marrow transplant after kidney transplant (from either a living or deceased donor).
- Conditions
- Kidney Failure, Kidney Transplant; Complications, Chimera
- Trial name
- NCT05900401
- Testing
- Bone Marrow Transplant, Peripheral Blood Stem Cell Collection, Fludarabine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Living Donor Kidney Transplantation
TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation
This study will determine whether a preparatory regimen including total lymphoid irradiation (TLI), total body irradiation (TBI), anti-thymocyte globulin (ATG) and infusion of the donor hematopoietic stem cells when given along…
- Trial name
- NCT03943238
- Testing
- Infusion of Donor Hematopoetic Stem Cells and Recipient Tregs
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Stanford University
Kidney Failure
Induction of Donor Specific Tolerance in Recipients of Living Kidney Allografts by Donor FCRx Infusion
An open-label study to assess the safety, efficacy, and tolerance of FCRx cell therapy in adult recipients within 12 months after kidney transplantation from a living donor.
- Trial name
- NCT00497926
- Testing
- Enriched Hematopoietic Stem Cell Infusion
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Talaris Therapeutics Inc.
Function of Renal Transplant
Analysis of Foxp3 and Vimentin Expression in Renal Transplant Recipient
This observational study is designed to analyse the urinary mRNA expression of Foxp3 and Vimentin, two genes involved in tolerance and early graft dysfunction in 500 renal transplant recipients from 17 renal transplant site in…
- Trial name
- TUFEV (NCT01443013)
- Testing
- Renal Transplant
- Where
- France
- Volunteers
- 266 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris