Clinical trials: Kidney Transplantation
Vaccination; Infection
Study of the Impact of Time of Vaccination on Response to Influenza Vaccine in Kidney Transplant Recipients -ChronoVAX
Immune response to influenza vaccine in kidney transplant patients
- Trial name
- CHRONOVAX (NCT06088563)
- Testing
- Vaccine injection
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Kidney Transplant
Cell-mediated Immune Response to Influenza Vaccine
Influenza virus is an important cause of morbidity in the transplant population and can lead to viral and bacterial pneumonia. Although the annual influenza vaccine is recommended for organ transplant patients, studies have shown…
- Trial name
- NCT00677547
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Kidney Transplantation, Cytomegalovirus Infections, EBV Infection
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients.
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, EBV Infection, Antiviral Prophylaxis
- Trial name
- NCT07294547
- Testing
- Valacyclovir (Valtrex), Valganciclovir (Valcyte)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplantation
A Study to Evaluate the Safety and Efficacy of FK506E (MR4) in Patients Undergoing Primary Kidney Transplantation
The purpose of this study is to evaluate and to compare the efficacy and safety of a triple modified release tacrolimus FK506E (MR4) / MMF / steroid regimen with a triple standard tacrolimus FK506 / MMF / steroid regimen in…
- Trial name
- NCT00189839
- Testing
- tacrolimus
- Where
- 80 sites in Argentina, Australia and 21 more
- Volunteers
- 699 people
- Sponsor
- Astellas Pharma Inc
Kidney Transplantation
An Observational Study on Renal Function in Kidney Transplant Participants on Immunosuppressive Therapy Containing Mycophenolate Mofetil
This observational study will evaluate renal function in participants who underwent renal allograft transplantation and are started on combined immunosuppressive treatment containing mycophenolate mofetil (CellCept).
- Trial name
- ORANGE (NCT01672957)
- Testing
- Mycophenolate Mofetil, Immunosuppressive Therapy
- Where
- 2 sites in Hungary
- Volunteers
- 128 people
- Sponsor
- Hoffmann-La Roche
Chronic Kidney Disease Requiring Chronic Dialysis
Smart and Fit for Kidney Transplantation
This study is a randomised controlled intervention trial for patients with chronic kidney disease who are on the waiting list for a kidney transplantation (n=200).
- Trial name
- S&F4NTx (NCT06040281)
- Testing
- intensive individual support in nutrition and exercise, Usual Care
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Vascular Diseases, Arterial Stiffness
Relation Between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
Relation between Renin-Angiotensin Gene Polymorphisms, Plasma Adiponectin and Arterial Stiffness in Renal Transplant Recipients
- Trial name
- NCT00221533
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- University Hospital, Ghent
Kidney Transplantation, Ischemic Reperfusion Injury
The Effect of Remote Postconditioning on Graft Function in Patients Undergoing Living-related Kidney Transplantation
The purpose of this study is to investigate whether upper limb ischemic postconditioning can improve renal function and decrease ischemic-reperfusion injury in patients undergoing living donor kidney transplantation.
- Conditions
- Kidney Transplantation, Ischemic Reperfusion Injury, Remote Ischemic Postconditioning
- Trial name
- NCT01363687
- Testing
- remote ischemic postconditioning
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Kidney Transplant Rejection
Using MSCs for Chronic Active Antibody Mediated Rejection
Mesenchymal stem cell (MSCs) therapy has already been studied in kidney transplant recipients (KTRs), and the available data showed that it is safe and well tolerated.
- Trial name
- NCT07005687
- Testing
- Stem Cells
- Volunteers
- 10 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Latent Tuberculosis Infection
Interferon Gamma Release Assays (IGRA) Testing Versus Tuberculin Skin Test in Renal Transplant Recipients
Interferon gamma release assays (IGRA) have been shown to be more specific and sensitive for the detection of tuberculosis (latent or active infection) than the tuberculin skin test (TST) in immunocompetent individuals.
- Trial name
- NCT01608685
- Where
- Switzerland
- Volunteers
- 205 people
- Sponsor
- Ligue Pulmonaire Genevoise
De Novo Kidney Transplantation
A Study to Assess the Efficacy and Safety of Alefacept in Kidney Transplant Recipients
The purpose of this study is to determine whether alefacept is effective and well tolerated when used with a combination of tacrolimus, mycophenolate mofetil and steroids versus a combination therapy of placebo, tacrolimus and…
- Trial name
- NCT00617604
- Testing
- Alefacept, Tacrolimus, Mycophenolate Mofetil
- Where
- 33 sites in Austria, Belgium and 10 more
- Volunteers
- 218 people
- Sponsor
- Astellas Pharma Inc
End-stage Renal Disease
Evaluation of the Level of Expression of CD45RC on T Lymphocytes as a Predictive Biomarker of Acute Rejection After Renal Transplantation
Chronic renal failure is a major public health problem in industrialized countries, due to its frequency - about 3 million patients in France - and its socio-economic impact.
- Trial name
- ECLAT (NCT03994497)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Renal Transplantation
Safety, Tolerability and Efficacy of Everolimus With Lower Versus Higher Levels of Tacrolimus in de Novo Renal Transplant Patients
This study will assess the safety and efficacy of everolimus with basiliximab, corticosteroids and lower levels versus higher levels of tacrolimus in de novo renal transplant recipients.
- Trial name
- NCT00170833
- Testing
- Everolimus
- Volunteers
- 80 people
- Sponsor
- Novartis Pharmaceuticals
Comparative Study, Immunosuppressive Agents
An Open, Single Centre, Randomised, Parallel Group Study to Investigate Three Different Immunosuppressive Regimens
An open, single center, randomised study to investigate three different immunosuppressive regimens for de novo renal transplant recipients: 1.
- Trial name
- SterFreePlus (NCT01183247)
- Testing
- Rapamycin, Everolimus, Prednisone
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- University Hospital, Basel, Switzerland
End Stage Renal Disease
PROlonged Ex-vivo Normothermic Machine PERfusion for Kidney Regeneration
The investigators would like to introduce and clinically evaluate prolonged normothermic machine perfusion (PNMP) to preserve and assess high-risk donor kidneys prior to transplantation.
- Trial name
- PROPER (NCT04693325)
- Testing
- Prolonged normothermic machine perfusion
- Where
- 2 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- Leiden University Medical Center
Hyperlipidemias
Lipid Management in Renal Transplant Recipients Using Evolocumab.
Cardiovascular disease is the leading cause of mortality after renal transplantation, accounting for more than 30% of deaths. Elevated lipid levels (hyperlipidemia) are a frequent finding following transplantation and the…
- Trial name
- NCT04608474
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Brigham and Women's Hospital
Glomerulonephritis
Study on Efficacy and Safety of LNP023 in C3 Glomerulopathy Patients Transplanted and Not Transplanted
The study is an open-label, two cohort non-randomized study evaluating the efficacy, safety, and pharmacokinetics of LNP023 in patients with C3G (Cohort A) and patients who have undergone kidney transplant and have C3G recurrence…
- Trial name
- NCT03832114
- Testing
- LNP023
- Where
- 9 sites in United States, France and 4 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Renal Transplantation, Laparoscopic Nephrectomy
Erector Spinae Plane Block in Renal Transplantation Donors
Erector Spina Plan Block (ESPB) is a relatively new, easy-to-apply and safe regional anesthesia technique used to provide postoperative analgesia in various surgeries.
- Conditions
- Renal Transplantation, Laparoscopic Nephrectomy, Erector Spinae Plane Block
- Trial name
- NCT04863716
- Testing
- Erector Spinae Plane Block, Intravenous fentanyl patient control device
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Koc University Hospital
BK Virus Infection
Safety and Efficacy Study of Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients
This study is examining the safety and efficacy of converting anti-rejection therapy from mycophenolic acid (MPA) to Zortress (everolimus) in renal transplant recipients with BK virus infection.
- Trial name
- NCT01624948
- Testing
- Everolimus, Mycophenolic acid dose reduction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Acute Kidney Injury, Chronic Kidney Diseases
Neohepatic Albumin-Bilirubin Scores on Renal Outcomes in Living-donor Liver Transplantation Recipients
This study investigates the association between post-reperfusion (neohepatic) ALBI scores and post-LT renal outcomes in living-donor LT (LDLT) recipients.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Graft Failure
- Trial name
- NCT06340607
- Where
- South Korea
- Volunteers
- 3,422 people
- Sponsor
- Asan Medical Center