Clinical trials: Kidney-pancreas Transplantation
Pancreas-Kidney Transplantation
Simultaneous Pancreas-kidney Transplantation With Campath Protocol
The purpose of this study is to determine and compare the efficacy of Campath-1H/Tacrolimus versus ATG/Tacrolimus/MMF therapy in conjunction with initial short-term steroids in Type 1-diabetic patients undergoing simultaneous…
- Trial name
- NCT00316810
- Testing
- Alemtuzumab, Rabbit Anti-Human Thymocyte Globulin
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Dr. Claudia Bösmüller
Diabetes, Immunosuppression
Evaluate Tolerability of Myfortic®/Simulect® and Tacrolimus Without Steroids in Three Patient Populations
This study is designed to evaluate the tolerability of Myfortic®/Simulect® combination in diabetic patients in a steroid free regimen.
- Trial name
- NCT01387659
- Testing
- Gastric emptying test
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Lung Transplantation, Cystic Fibrosis
Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC)
Chronic renal failure is a serious complication of lung transplantation especially in patients with cystic fibrosis. Their medical history prior to the Lung Transplantation has already exposed to kidney damage.
- Conditions
- Lung Transplantation, Cystic Fibrosis, Renal Failure
- Trial name
- MUCO-IRC (NCT01572194)
- Testing
- Urinary levels of PIIINP as a marker of changes in renal function
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Nantes University Hospital
Kidney-Pancreas Transplantation
Prograf-Advagraf Cross Over Conversion Study
The present study is aimed at evaluating the impact of a switch from Prograf to Advagraf on renal function, trough tacrolimus levels, drug-related adverse effects and adherence in stable recipients of kidney-pancreas transplants.
- Trial name
- NCT01797341
- Testing
- Tacrolimus
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes Mellitus
Islet After Kidney Transplant for Type 1 Diabetes
The purpose of this study is to determine if prolonged administration of the anti TNF (tumor necrosis factor)-Alpha agent etanercept is associated with enhanced graft survival in patients undergoing islet after kidney…
- Trial name
- NCT00784966
- Testing
- etanercept
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Cancer
High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill…
- Trial name
- NCT00002854
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- City of Hope Medical Center
Simultaneous Kidney and Pancreas Transplantation
Optimization of NULOJIX® Usage Towards Minimizing CNI Exposure in Simultaneous Pancreas and Kidney Transplantation
The purpose of this study is to find out if the drug NULOJIX® (belatacept) will minimize the amount of other anti-rejection medications necessary and thereby reduce the long-term side effects caused by the other medications.
- Trial name
- NCT01790594
- Testing
- Belatacept, methylprednisolone, Anti-thymocyte Globulin (Rabbit)
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections, Kidney Transplant Infection
Letermovir (Prevymis) for CMV in Kidney and Pancreas Transplant Recipients
This study is designed to assess how effective letermovir is in preventing recurrence of cytomegalovirus (CMV) infection in adult kidney or kidney/pancreas transplant recipients who are UW Health patients.
- Conditions
- Cytomegalovirus Infections, Kidney Transplant Infection, Pancreas Transplant
- Trial name
- NCT06407232
- Testing
- Letermovir
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Wisconsin, Madison
Gadolinium Toxicity
In Vitro Study of the Effect of Gadolinium Contrast on Fibrocytes
Gadolinium contrast agents are frequently administered for MRI imaging. Very little is known of its toxicity outside of patients with reduced renal function.
- Trial name
- NCT02512796
- Testing
- Gadolinium contrast dye
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Virginia
CMV Disease, Viral Resistance
Long Term Use of Valganciclovir for Prophylaxis of CMV Disease in Kidney and Pancreas Transplant Patients
CMV viral disease negatively affects transplant patients. CMV is the most prevalent infection in transplant patients and 3 month drug regimens to prevent the virus have been mostly unsuccessful, usually after the drug has been…
- Conditions
- CMV Disease, Viral Resistance, Rejection, Death
- Trial name
- NCT00225394
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Massachusetts, Worcester
Transplant;Failure,Kidney, Transplant; Failure, Heart
EASE-SOT Pilot Study
Many transplant recipients may experience physical and emotional symptoms, such as anxiety, fatigue, sleep problems, pain, etc. Often, these symptoms are not reported or managed well, and can affect a patient's quality-of-life.
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Heart, Transplant; Failure, Liver, Transplant; Failure, Pancreas
- Trial name
- NCT06396702
- Testing
- EASE-SOT
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Renal Failure Chronic Requiring Dialysis, Diabetes Mellitus, with Complications
Magnesium Supplementation in Simultaneous Pancreas-Kidney Transplantation
Magnesium is essential in human physiology. Simultaneous pancreas-kidney (SPK) transplant recipients frequently experience hypomagnesemia. The effects of hypomagnesaemia are harmful.
- Conditions
- Renal Failure Chronic Requiring Dialysis, Diabetes Mellitus, with Complications, Glomerulosclerosis, Pancreatic Insufficiency (Exocrine and Endocrine)
- Trial name
- NCT06766786
- Testing
- Magnesium Sulfate high dose
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Dr Olu Bamgbade, MD, FRCPC
Surgery
The Feasibility of Sugammadex for General Anesthesia in Patients Undergoing Kidney and Pancreas Transplantation Surgery
The effectiveness and safety of sugammadex were confirmed in pancreas kidney transplatation patients for reversal of deep neuromuscular blockade induced by rocuronium.Sugmmadex can reduce the length of PACU stay.
- Trial name
- NCT04944303
- Testing
- Sugammadex, Normal saline
- Where
- 2 sites in China
- Volunteers
- 52 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Diabetes Mellitus Patients With Kidney Transplantation
Hybrid Closed-Loop in Diabetes Post-Kidney Transplant: A Randomized Trial
Objective: To evaluate the short-term blood glucose control effect of the closed-loop system combined with a regular insulin pump and continuous glucose monitoring (CGM) in hospitalized patients with diabetes after kidney…
- Trial name
- NCT06962410
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanxi Bethune Hospital
Diabetes Mellitus
Studies of Organ Transplantation in Animals and Man
A. To study the effects of pancreas transplantation (PT) on the structural abnormalities of diabetic nephropathy (DN) in patients with type 1 (insulin-dependent) diabetes mellitus (type 1 D).
- Trial name
- NCT00156364
- Where
- United States
- Volunteers
- 655 people
- Sponsor
- Michael Mauer, MD
Kidney Transplant Rejection, Positive FCXM (T or B Cell Positive)
Spleen Transplant in Solid Organ Transplantation
Although the notions that kidney transplantation is the treatment of choice for patients with end-stage renal disease and that simultaneous kidney and pancreas transplant is the only treatment able to restore euglycemia in…
- Conditions
- Kidney Transplant Rejection, Positive FCXM (T or B Cell Positive), Positive CDC Cross-Match (B Cell Positive), Kidney/Pancreas Transplant Rejection
- Trial name
- NCT04827186
- Testing
- Spleen Transplantation/Removal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Kidney Pancreas Transplantation
CIRTEN-Simultaneous Pancreas-Kidney Transplant Recipients
This is a Phase II/III, Single-center, Prospective, Open-label, Single Arm Study of 20 Simultaneous Kidney Pancreas recipients who received a transplant at least 3 months, but no more than 5 years prior, with a history of tremors…
- Trial name
- NCT03769298
- Testing
- Envarsus XR
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Madison
Kidney Transplant, Kidney Pancreas Transplant
The Effect of Neuromuscular Stimulation on Post-Transplant Leg Edema
This will be a randomized, controlled trial involving kidney and kidney pancreas transplant patients. There will be 2 groups and patients that will be randomized to one of the two groups.
- Conditions
- Kidney Transplant, Kidney Pancreas Transplant, Edema
- Trial name
- NCT01860820
- Testing
- Geko device
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
type1diabetes, Renal Failure
Kidney Alone Versus Islet-After-Kidney in Type 1 Diabetic Kidney Transplant Recipient.
Islet transplantation is associated with a benefit on glycaemic control compared to optimized insulin therapy in recent clinical trials.
- Conditions
- type1diabetes, Renal Failure, End Stage Renal Disease
- Trial name
- KA-IAK (NCT05662267)
- Testing
- Pancreatic islet transplantation after kidney transplantation
- Where
- France
- Volunteers
- 327 people
- Sponsor
- University Hospital, Lille
Diabetes Mellitus；Uremia
Clinical Analysis of Simultaneous Pancreas-kidney Transplantation for End-stage Renal Disease Associated With Diabetes Mellitus
The first pancreas transplantation was performed in 1966, by 2015, more than 40,000 pancreas transplantation have been performed worldwide.
- Trial name
- NCT05497232
- Testing
- simultaneous pancreas-kidney transplantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University