Clinical trials: Knee
Osteoarthritis
A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
The primary aim is to assess if PF-00592379 is able to reduce pain in patients with osteoarthritis of the knee.
- Trial name
- NCT00483977
- Testing
- Oxycodone, PF-000592379
- Where
- 21 sites in United States
- Volunteers
- 113 people
- Sponsor
- Pfizer
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Benchmarking the iOS Balance Application Against the Berg Balance Test
This study aims to benchmark the performance of an iOS application against the Berg Balance Scale (BBS), which is the most commonly used assessment tool by clinicians for measuring balance across the continuum from acute care to…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Ankle Injuries, Knee Injuries
- Trial name
- BBAaBBT (NCT02705690)
- Testing
- iOS Balance Application
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stannah Stairlifts
Surgical Wound
A Post-Market Clinical Investigation on Mepilex Border Post-Op
This is a retrospective, observational (non-interventional), single-arm, single-centre, post-market clinical investigation designed to verify clinical performance and safety of Mepilex Border Post-Op when used according to…
- Trial name
- ARCTIS (NCT04994145)
- Where
- Belgium
- Volunteers
- 560 people
- Sponsor
- Molnlycke Health Care AB
Knee Disease
Study Conducted on Patients Operated With a FHK ASYMETRIQUE to Confirm Security and Performance of the Device
This study is a post-market clinical follow-up conducted in order to collect long-term data on security and performance of the FHK asymetrique prosthesis, which is intended to be implanted in case of total knee replacement, when…
- Trial name
- NCT04221581
- Testing
- Knee prosthesis - FHK ASYMETRIQUE total knee prosthesis
- Where
- 3 sites in France
- Volunteers
- 43 people
- Sponsor
- FH ORTHO
Osteoarthritis of the Knee
Dose Finding Study of Bone Morphogenetic Protein 7 (BMP-7) in Subjects With Osteoarthritis (OA) of the Knee
The objectives of the study are to evaluate the safety and efficacy of intraarticular BMP-7 for the treatment of osteoarthritis of the knee.
- Trial name
- NCT01111045
- Testing
- Bone morphogenetic protein 7
- Where
- 25 sites in United States
- Volunteers
- 355 people
- Sponsor
- Stryker Biotech
Knee Osteoarthritis
The Press Fit Condylar (P.F.C.) Sigma Metal-backed Versus All-poly
The primary objective of this investigation was to evaluate \& compare the performance of the P.F.C. Sigma Knee Cruciate-retaining all-polyethylene and metal-backed tibia components using RSA.
- Trial name
- NCT00733928
- Testing
- PFC Sigma knee with all-poly tibial component, PFC Sigma knee with metal backed tibia
- Where
- United Kingdom
- Volunteers
- 67 people
- Sponsor
- DePuy International
Total Knee Arthroplasty
CT Assessment of Minimally Invasive Surgery and Computer Assisted Navigation in Total Knee Arthroplasty
The functional flexion axis of the knee can be established by computer-assisted intra-operative data, through range of motion techniques, not specific landmarks such as epicondyles.
- Trial name
- NCT00409266
- Testing
- Computer assisted navigation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stryker Instruments
Osteoarthritis, Knee
JOURNEY™ II CR Total Knee System
The purpose of this study is to evaluate the safety and effectiveness of the JOURNEY™ II CR Total Knee System in subjects with degenerative joint disease (DJD) requiring primary total knee replacement.
- Trial name
- NCT02440672
- Testing
- JOURNEY™ II CR Total Knee System (J II CR TKS)
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
Evaluation of the Efficacy and Safety of Nise 100 mg in the Management of Osteoarthrosis (Gonarthrosis)
Study is conducted to evaluate safety and efficacy in patients with osteoarthritis
- Trial name
- NISE-2013 (NCT02922712)
- Testing
- NISE
- Volunteers
- 202 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Pain Management, Osteoarthritis
The Effectiveness of Heat Treatment on Knee Pain in Patients With Osteoarthritis - an International, Multicenter Clinical Investigation
This post-market clinical follow-up, open-label, multicenter clinical investigation is designed to investigate the effectiveness, safety and tolerability of ThermaCare® Knee Heatwraps in the painful knee joint due to…
- Trial name
- NCT06650631
- Testing
- Knee Heatwraps
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Osteoarthritis of the Knee
A Study to Evaluate the Safety and Efficacy of Topically Applied TV-45070 (Ointment) in Participants With Primary Osteoarthritis (OA) Affecting a Single Knee
The primary purpose of the study is to evaluate the change from baseline after 4 weeks of topical administration of TV-45070 (4% and 8% ointment) compared with placebo for the relief of symptoms of primary OA affecting a single…
- Trial name
- NCT02068599
- Testing
- TV-45070
- Where
- 42 sites in United States
- Volunteers
- 389 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Knee Osteoarthritis
A Phase 4 Study of Imrecoxib in Treatment of Knee Osteoarthritis
The purpose of this study is to evaluate the efficacy and safety of Imrecoxib in the treatment of patients with knee osteoarthritis.
- Trial name
- NCT01985165
- Testing
- Imrecoxib
- Where
- 19 sites in China
- Volunteers
- 2,400 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Knee Osteoarthritis
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.
- Trial name
- NCT06741098
- Testing
- NCR100, 0.9% Normal saline
- Volunteers
- 162 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Osteoarthritis, Post-traumatic Arthritis
ATTUNE Single-Use Instrumentation vs. ATTUNE Reusable Instrumentation in Primary Total Knee Arthroplasty
This post-marketing investigation will evaluate the mechanical axis alignment achieved with the ATTUNE Single-Use Instrumentation (SUI) as compared to the mechanical axis alignment achieved with the ATTUNE Reusable…
- Trial name
- SOLO (NCT02574312)
- Testing
- ATTUNE TKA with ATTUNE RUI, ATTUNE TKA with ATTUNE SUI
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 88 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Assessment of the Efficacy of Andrographis Paniculata in Subjects With Mild to Moderate Osteoarthritis
This is a 12 weeks randomized, double-blind, placebo-controlled clinical study to assess the effect of Andrographis Paniculata at low dose of 300 mg/day and high dose of 600 mg/day in the study population in the age range of…
- Trial name
- A Paniculata (NCT03262792)
- Testing
- Andrographis Paniculata
- Where
- 4 sites in India
- Volunteers
- 108 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis, Knee, Pain
Tapentadol (CG5503)
The purpose of this trial is to evaluate the effectiveness (level of pain control) and safety of orally administered tapentadol (CG5503) Extended Release (ER) (base) at doses of 100-250 mg twice daily in patients with moderate to…
- Trial name
- NCT00421928
- Testing
- oxycodone, tapentadol (CG5503)
- Volunteers
- 1,030 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Peripheral Arterial Disease Below the Knee, Peripheral Arterial Disease, Rutherford 4 and 5 with Possibility to Improve Vascularization
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters ("BTK Multicath Registry") A non-randomized clinical registry This study is designed to obtain preliminary data on clinically…
- Trial name
- NCT06906055
- Testing
- Multicath, Standard of Care (SOC)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Summa Therapeutics, LLC
Osteoarthritis
Osteoarthritis Topical Treatment
This is a phase 2a clinical trial performed to evaluate the efficacy of a topical treatment of ibuprofen compared to the use of a placebo topical treatment. A multi-center, double-blinded, randomized placebo controlled study.
- Trial name
- ANTIPAIN (NCT01496326)
- Testing
- Ibuprofen
- Where
- 5 sites in Switzerland
- Volunteers
- 75 people
- Sponsor
- BioChemics, Inc.
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate Biomarkers of Senescence in Patients With Osteoarthritis of the Knee
This is an exploratory non-drug, interventional biomarker study in approximately 30 eligible patients with active osteoarthritis to investigate the degree of senescence-associated disease.
- Trial name
- NCT03100799
- Testing
- Arthroscopy, Arthrocentesis, MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Unity Biotechnology, Inc.
Post-operative Pain
Post-operative Efficacy and Safety Study
The purpose of this study was to compare the analgesic efficacy of 5 mg oxymorphone IR with placebo in patients with mild to moderate pain following outpatient knee arthroscopy.
- Trial name
- NCT00904085
- Testing
- Oxymorphone IR
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company