Clinical trials: Knee
Articular Cartilage Lesion of the Femoral Condyle
RCT of ChondroCelect® (in an ACI Procedure) vs Microfracture in the Repair of Cartilage Defects of the Knee
This is a phase III, multicenter, open-label, randomized controlled trial of ChondroCelect® in an Autologous Chondrocyte Implantation (ACI) procedure compared to the procedure of microfracture (MF) in the repair of symptomatic…
- Trial name
- TIGACT01 (NCT00414700)
- Testing
- ChondroCelect implantation, Microfracture
- Where
- 12 sites in Belgium, Croatia and 2 more
- Volunteers
- 118 people
- Sponsor
- TiGenix n.v.
Deep Vein Thrombosis (DVT), Blood Clots
Below Knee DVT Study
Hospitalized patients are at risk of developing blood clots in the legs (Deep Vein Thrombosis or DVT), which can lead to death if those clots break off and migrate to the lungs.
- Trial name
- NCT03805672
- Testing
- Low Dose Enoxaparin, High Dose Enoxaparin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Oregon Health and Science University
Osteoarthritis of the Knee
Structured Treatment of Osteoarthritis of the Knee With or Without Total Knee Replacement
The purpose of this study is to test whether surgical insertion of total knee replacement provides further improvement in quality of life, pain and function in addition to an algorithm for systematic non-surgical treatment…
- Trial name
- MEDIC (NCT01410409)
- Testing
- Neuromuscular training (NEMEX-TJR), Paracetamol, Burana
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Osteoarthritis, Knee, Hypertension
Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and Hypertension
The purpose of the Staying Active with Arthritis (STAR) research study is to determine if a 6-month program will improve leg exercise, fitness walking, and clinical outcomes (function, blood pressure, leg strength, pain, fatigue…
- Trial name
- STAR (NCT01280903)
- Testing
- STAR Intervention, Attention-Control
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Pittsburgh
Blood Loss
The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
The purpose of this study is to determine if the agent, Floseal, can decrease the amount of blood patients lose after total knee replacement (TKR) surgery.
- Trial name
- NCT00990288
- Testing
- Hemostatic Matrix
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hospital for Special Surgery, New York
Inflammation, Knee Pain Chronic
Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
This research evaluated the effects of UCII, glucosamine and curcumin supplementation on knee pain and inflammation.
- Trial name
- NCT06581094
- Testing
- UCII, glucosamine and curcumin
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteoarthritis of the Knee
Efficacy Study of an Unloading Brace for Knee Osteoarthritis
Subjects with symptomatic unicompartmental osteoarthritis of the knee will be invited to participate in this randomized study. Subjects will be assigned to either a Fusion Osteoarthritis Knee Brace group, or a control group that…
- Trial name
- NCT02150057
- Testing
- Breg Fusion Unloading Brace
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Andrews Research & Education Foundation
Arthropathy of Knee
Adductor Canal Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Peripheral nerve blocks catheters of the femoral nerve have long been used for perioperative analgesia in total knee arthroplasty (TKA). These blocks provide effective analgesia and patient satisfaction for surgical pain relief.
- Trial name
- NCT03133481
- Testing
- Adductor Canal Nerve Block, Femoral Nerve Block
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pain
A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty
The purpose of this study is to evaluate the exposure of diclofenac in the plasma and in the knee joint following topical administration of DDEA gel 4 gram (g) applied twice daily for 7 days.
- Trial name
- NCT03497039
- Testing
- Diclofenac Diethylamine (DDEA) gel
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Overuse Injury, Body Mass Index in Athletes
Hyaluronic Acid in Overuse Knee Pain
Sports activity represents part of day living people, a knee pain originated by high demand joint activity could represent a limitation to continue sports.
- Trial name
- NCT05450458
- Testing
- KNEE JOINT INFILTRATION WITH HYALURONIC ACID WITH SORBITOL SYNOLIS VA
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Regional Tlalnepantla
Anterior Cruciate Ligament Injuries
Neuroplastic Mechanisms Underlying Augmented Neuromuscular Training
The purpose of this study is to determine the neural mechanisms of augmented neuromuscular training (aNMT). Participants will complete a 6-week course of neuromuscular training with either aNMT biofeedback or sham biofeedback.
- Trial name
- NCT04069520
- Testing
- aNMT Biofeedback
- Where
- 2 sites in United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Emory University
Knee Arthroplasty, Total
Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial
Total Knee Arthroplasty (TKA) is a common orthopedic surgery usually leads to Bleeding. The null hypothesis of this study was that TA has no effect on post surgical bleeding in patients undergoes TKA.
- Trial name
- NCT02327117
- Testing
- Tranexamic Acid, Normal saline
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Isfahan University of Medical Sciences
Pain, Arthroplasty, Replacement, Knee
Comparison of Levobupivacaine and Ropivacaine for Femoral Neural Block
The anaesthetic management of patients undergoing total knee replacement is still not standardised. Epidural analgesia is common, but is associated with bilateral lower limb motor block and limited mobilisation.
- Trial name
- NCT01172197
- Testing
- Levobupivacaine, Ropivacaine
- Volunteers
- 14 people
- Sponsor
- NHS Tayside
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Difference Between Femoral Nerve Block and Saphenous Block
Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural to provide long-lasting pain relief with or without a femoral nerve block (FNB).
- Trial name
- NCT01505374
- Testing
- Study Technique, Control Technique
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Knee
Efficacy and Safety of G001 in Patients With Osteoarthritis (OA) of the Knee
Phase 2 multicenter, double-blind, randomized, parallel-group, vehicle-controlled study to evaluate the efficacy, safety, and local tolerability of G001 topical gel compared to matching Vehicle topical gel in patients with…
- Trial name
- NCT05007808
- Testing
- G001 Topical Gel, Vehicle
- Where
- 10 sites in Canada
- Volunteers
- 210 people
- Sponsor
- BUZZZ Pharmaceuticals Limited
Knee Arthropathy, Hip Arthropathy
Preoperative Acupuncture for Total Knee or Hip Arthroplasty
Open-label, randomized controlled trial to determine the effect of preoperative acupuncture on preoperative anxiety and postoperative pain for high-anxiety patients undergoing total hip or knee arthroplasty.
- Conditions
- Knee Arthropathy, Hip Arthropathy, Anxiety
- Trial name
- (Acupuncture) (NCT06099223)
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hartford Hospital
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim