Clinical trials: Knee
Muscle Atrophy, Quality of Life
Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults
As a function of the growing population of older adults, an estimated 3.48 million total knee arthroplasty (TKA) procedures will be performed annually in the U.S. by 2030.
- Trial name
- NCT02145949
- Testing
- Essential Amino Acids (EAA)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Oregon
Stroke
Powered Orthotic Exoskeleton Training in Stroke
Veterans who suffer strokes often have disturbances in the ability to walk that reduces independence and quality of life. Alterations in gait combined with general decreased activity are associated with reduced muscle strength of…
- Trial name
- POETS (NCT04241848)
- Testing
- Keeogo, Ambulation training
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Radiculopathy
Effect of Neural Mobilization on Lumbosacral Radiculopathy Patients With Peripheral Sensitization
The primary purpose of this study was to investigate the effects of slider and tensioner techniques on pain, hip and knee ROM in lumbosacral radiculopathy patients with peripheral sensitization.
- Trial name
- NCT03621878
- Testing
- Neural mobilization exercises -Tensioner technique, Neural mobilization exercises -Slider technique, Transcutaneous Electrical Nerve Stimulation (TENS)
- Volunteers
- 51 people
- Sponsor
- Mohammed Al-Ghamdi
Osteoarthritis
A Study Evaluating the Safety, Tolerability, and Efficacy of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
The purpose of this study is to assess the efficacy, safety, and tolerability of three different strengths of SM04690 injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT02536833
- Testing
- SM04690
- Where
- 36 sites in United States
- Volunteers
- 455 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Arthritis
Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the long-term analgesic efficacy and safety of tanezumab for patients with osteoarthritis (OA) of the knee or hip currently experiencing partial benefit from, and are tolerating…
- Trial name
- NCT00809354
- Testing
- NSAID, tanezumab
- Where
- 333 sites in United States, Canada and 10 more
- Volunteers
- 2,720 people
- Sponsor
- Pfizer
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteo Arthritis Knee
Geniculate Artery Embolization for Knee Pain Secondary to Osteoarthritis (OA)
Purpose: To evaluate embolization as a treatment for OA related knee pain versus placebo to demonstrate the actual effect of embolization on pain and disability.
- Trial name
- NCT03362957
- Testing
- Geniculate Artery Embolization
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Pain, Depression
Stepped Care for Depression and Musculoskeletal Pain
This study will evaluate the effectiveness of a stepped care approach in treating depression and reducing pain.
- Trial name
- NCT00118430
- Testing
- Stepped Care, Antidepressants, Usual Care
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Arthropathy of Knee Joint
Neuromuscular Electrical Stimulation (NMES) for Improving Outcomes Following Total Knee Arthroplasty (TKA)
The current standard for rehabilitation after TKA consists of guided exercise therapy for up to 12 weeks after surgery. This includes inpatient, home, and outpatient therapy.
- Trial name
- NCT03044028
- Testing
- CyMedica Orthopedics QB1 e-vive™ system
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis Knee Pain
A Study of Duloxetine in Patients With Osteoarthritis Knee Pain
The primary purpose of this study is to determine if duloxetine 60 mg once daily (QD) reduces pain severity in patients with osteoarthritis (OA) knee pain compared with placebo.
- Trial name
- NCT00945945
- Testing
- Duloxetine (DLX)
- Where
- 26 sites in United States, Germany and 6 more
- Volunteers
- 424 people
- Sponsor
- Eli Lilly and Company
Cartilage Injury of Knee
A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the Knee
This is a Phase 2, double-blind, multicenter, randomized, placebo-controlled trial to evaluate the efficacy and safety of Sprifermin (AS902330) (recombinant human fibroblast growth factor-18 [rhFGF-18]) as an adjunct treatment to…
- Trial name
- NCT01689337
- Testing
- Sprifermin (AS902330)
- Volunteers
- 1 people
- Sponsor
- EMD Serono
Neuropathic Pain, Knee Osteoarthritis
Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging and Neuropathic Pain in Knee Osteoarthritis
The primary objective of this study is to identify osteoarthritis (OA) structural changes, as assessed by MRI, that best correlate with the presence of neuropathic pain (NP) using the PainDETECT questionnaire (PainDETECT ≥ 13) on…
- Trial name
- NCT01733277
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- ArthroLab Inc.
Amputation, Amputation; Traumatic, Leg, Lower
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
The goal of this proposed project is to gather community-based data from the K4-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to…
- Conditions
- Amputation, Amputation; Traumatic, Leg, Lower, Limb; Absence, Congenital, Lower, Prosthesis User
- Trial name
- NCT05267639
- Testing
- Power Knee
- Where
- 2 sites in United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Liberating Technologies, Inc.
Amputation
Clinical Investigation (Beta) of a New Developed Prosthetic Knee
The aim of this investigation is to evaluate the efficacy of the investigational device regarding performance improvements and satisfaction in descending activities for moderate to high active prosthesis users within the intended…
- Trial name
- NCT06748729
- Testing
- Navii Knee
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Össur Iceland ehf
Osteoarthritis
BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis
This study will evaluate the efficacy and safety of a single intra-articular injection of 2 doses of BOTOX® (onabotulinumtoxinA) compared with placebo as treatment for knee osteoarthritis symptoms.
- Trial name
- NCT02230956
- Testing
- onabotulinumtoxinA, Normal Saline
- Where
- 3 sites in United States, Czechia and 1 more
- Volunteers
- 176 people
- Sponsor
- Allergan
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Werewolf Flow 50 During ACL Reconstruction
The aim of this study is to compare the outcomes, ease of use, and cost of the Werewolf FLOW50 device to the institutional standard of care which is does not include the use of electrocautery devices during anterior cruciate…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Arthrofibrosis of Knee
- Trial name
- NCT04998656
- Testing
- Werewolf FLOW 50, Control
- Where
- 3 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of Colorado, Denver
Arthroplasty, Replacement, Knee
Triathlon Tritanium Knee Outcomes Study
The success of the Triathlon Tritanium Knee will be determined by comparing the rate of absence of revision for aseptic loosening of the tibial baseplate at 2 years with the rates reported in the literature.
- Trial name
- NCT02155712
- Testing
- Triathlon Tritanium Knee, Triathlon Knee
- Where
- 10 sites in United States
- Volunteers
- 680 people
- Sponsor
- Stryker Orthopaedics
Knee Osteoarthritis
Feasibility of Pain Informed Movement for Knee OA
The pain experience and its associated mechanisms in people with knee osteoarthritis (OA) are known to be complex and multidimensional.
- Trial name
- NCT04954586
- Testing
- Pain Informed Movement
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McMaster University
Knee Osteoarthritis, Arthroplasty Complications
Pre vs Post Block in Total Knee Arthroplasty (TKA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee arthroplasty can be observed with the substitution of a post operative adductor canal block for a preoperative…
- Conditions
- Knee Osteoarthritis, Arthroplasty Complications, Postoperative Pain
- Trial name
- NCT05974501
- Testing
- Dexamethasone, Acetaminophen, Lyrica
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Miami
Obstructive Sleep Apnea
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and is a risk factor for postoperative complications, including respiratory and cardiac events and delirium.
- Trial name
- Cytokine OSA (NCT02325687)
- Testing
- Lumbar Puncture (Standard-of-Care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
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